Development of postcastration syndrome and corrective effect of xenon in exponential dose regimen in young patients with gynecological cancers
Purpose of the study. Investigation of possible optimization of treatment in patients with breast cancer and cervical cancer with low-dose xenon therapy.Patients and methods. The study included 156 patients with pT1В2N0M0 cervical cancer (CC) and pT2N1M0 breast cancer (BC) of the reproductive age (2...
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| Format: | Article |
| Language: | Russian |
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ANO "Perspective of oncology"
2020-08-01
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| Series: | Южно-Российский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.cancersp.com/jour/article/view/69 |
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| author | O. I. Kit N. N. Popova A. I. Shikhlyarova E. M. Frantsiyants T. I. Moiseenko A. P. Menshenina G. V. Zhukova T. P. Protasova Yu. Yu. Arapova |
| author_facet | O. I. Kit N. N. Popova A. I. Shikhlyarova E. M. Frantsiyants T. I. Moiseenko A. P. Menshenina G. V. Zhukova T. P. Protasova Yu. Yu. Arapova |
| author_sort | O. I. Kit |
| collection | DOAJ |
| description | Purpose of the study. Investigation of possible optimization of treatment in patients with breast cancer and cervical cancer with low-dose xenon therapy.Patients and methods. The study included 156 patients with pT1В2N0M0 cervical cancer (CC) and pT2N1M0 breast cancer (BC) of the reproductive age (29–45 years) after radical treatment, including forced surgical castration in hormone-positive breast cancer with concomitant gynecological pathology. Since the formation of pathological syndromes, 1 cycle (5 sessions) of low-dose xenon inhalation therapy (XT) was performed, with an algorithm for xenon dose calculation and exposure according to the exponential pattern of decreasing concentration and increasing exposure, with an individual approach. Together with general clinical and laboratory examinations, we used international scales for assessing the severity of the patient condition by the Kupperman menopausal index (MMI), ESAS, quality of life (MOS-SF-36), in a modification of the Russian International Center, pain (VAS); the types of general adaptive reactions were identified by the method of L.Kh. Garkavi.Results. Important advantages of a new method associated with a rapid regression of pathological psychosomatic symptoms were revealed after XT. MMI values (p<0.05) decreased, 96.8% of patients reported no pain at all on activity, manifestations of neurovegetative disorders significantly decreased (p=0.02–0.04), and the coefficient of antistress reactions to stress increased, which was congruent with the data on improving the quality of life. Conclusion. High efficiency of the technology demonstrated possible prevention of surgical menopause development and clinical manifestations of postcastration syndrome in order to improve the quality of life and social rehabilitation of young patients with gynecological cancers. |
| first_indexed | 2024-04-10T03:41:33Z |
| format | Article |
| id | doaj.art-5827018f8f794714acb48a7fb0cd2ba6 |
| institution | Directory Open Access Journal |
| issn | 2686-9039 |
| language | Russian |
| last_indexed | 2024-04-10T03:41:33Z |
| publishDate | 2020-08-01 |
| publisher | ANO "Perspective of oncology" |
| record_format | Article |
| series | Южно-Российский онкологический журнал |
| spelling | doaj.art-5827018f8f794714acb48a7fb0cd2ba62023-03-13T07:19:28ZrusANO "Perspective of oncology"Южно-Российский онкологический журнал2686-90392020-08-011361710.37748/2687-0533-2020-1-3-115Development of postcastration syndrome and corrective effect of xenon in exponential dose regimen in young patients with gynecological cancersO. I. Kit0N. N. Popova1A. I. Shikhlyarova2E. M. Frantsiyants3T. I. Moiseenko4A. P. Menshenina5G. V. Zhukova6T. P. Protasova7Yu. Yu. Arapova8ФГБУ «НМИЦ онкологии» Минздрава РоссииФГБУ «НМИЦ онкологии» Минздрава РоссииФГБУ «НМИЦ онкологии» Минздрава РоссииФГБУ «НМИЦ онкологии» Минздрава РоссииФГБУ «НМИЦ онкологии» Минздрава РоссииФГБУ «НМИЦ онкологии» Минздрава РоссииФГБУ «НМИЦ онкологии» Минздрава РоссииФГБУ «НМИЦ онкологии» Минздрава РоссииФГБУ «НМИЦ онкологии» Минздрава РоссииPurpose of the study. Investigation of possible optimization of treatment in patients with breast cancer and cervical cancer with low-dose xenon therapy.Patients and methods. The study included 156 patients with pT1В2N0M0 cervical cancer (CC) and pT2N1M0 breast cancer (BC) of the reproductive age (29–45 years) after radical treatment, including forced surgical castration in hormone-positive breast cancer with concomitant gynecological pathology. Since the formation of pathological syndromes, 1 cycle (5 sessions) of low-dose xenon inhalation therapy (XT) was performed, with an algorithm for xenon dose calculation and exposure according to the exponential pattern of decreasing concentration and increasing exposure, with an individual approach. Together with general clinical and laboratory examinations, we used international scales for assessing the severity of the patient condition by the Kupperman menopausal index (MMI), ESAS, quality of life (MOS-SF-36), in a modification of the Russian International Center, pain (VAS); the types of general adaptive reactions were identified by the method of L.Kh. Garkavi.Results. Important advantages of a new method associated with a rapid regression of pathological psychosomatic symptoms were revealed after XT. MMI values (p<0.05) decreased, 96.8% of patients reported no pain at all on activity, manifestations of neurovegetative disorders significantly decreased (p=0.02–0.04), and the coefficient of antistress reactions to stress increased, which was congruent with the data on improving the quality of life. Conclusion. High efficiency of the technology demonstrated possible prevention of surgical menopause development and clinical manifestations of postcastration syndrome in order to improve the quality of life and social rehabilitation of young patients with gynecological cancers.https://www.cancersp.com/jour/article/view/69рак шейки маткирак молочной железыпосткастрационный синдромксенонотерапияэкспоненциальный режим дозированияадаптационные реакции |
| spellingShingle | O. I. Kit N. N. Popova A. I. Shikhlyarova E. M. Frantsiyants T. I. Moiseenko A. P. Menshenina G. V. Zhukova T. P. Protasova Yu. Yu. Arapova Development of postcastration syndrome and corrective effect of xenon in exponential dose regimen in young patients with gynecological cancers Южно-Российский онкологический журнал рак шейки матки рак молочной железы посткастрационный синдром ксенонотерапия экспоненциальный режим дозирования адаптационные реакции |
| title | Development of postcastration syndrome and corrective effect of xenon in exponential dose regimen in young patients with gynecological cancers |
| title_full | Development of postcastration syndrome and corrective effect of xenon in exponential dose regimen in young patients with gynecological cancers |
| title_fullStr | Development of postcastration syndrome and corrective effect of xenon in exponential dose regimen in young patients with gynecological cancers |
| title_full_unstemmed | Development of postcastration syndrome and corrective effect of xenon in exponential dose regimen in young patients with gynecological cancers |
| title_short | Development of postcastration syndrome and corrective effect of xenon in exponential dose regimen in young patients with gynecological cancers |
| title_sort | development of postcastration syndrome and corrective effect of xenon in exponential dose regimen in young patients with gynecological cancers |
| topic | рак шейки матки рак молочной железы посткастрационный синдром ксенонотерапия экспоненциальный режим дозирования адаптационные реакции |
| url | https://www.cancersp.com/jour/article/view/69 |
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