The role of Vit D and parathyroid hormone in clinical severity of patients with bipolar disorder
Introduction Vitamin D modulates the biosynthesis of neurotransmitters and neurotrophic factors, thus influencing mood and its alterations. Decreased blood levels of Vitamin D are involved in many psychiatric disorders, in particular, affective disorders. As regards bipolar disorder (BD), an assoc...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821002431/type/journal_article |
| _version_ | 1797616434127306752 |
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| author | C. Palummo L. Marone V. Caivano A. Vece L. Steardo M. Luciano A. Di Cerbo V. Del Vecchio A. Fiorillo |
| author_facet | C. Palummo L. Marone V. Caivano A. Vece L. Steardo M. Luciano A. Di Cerbo V. Del Vecchio A. Fiorillo |
| author_sort | C. Palummo |
| collection | DOAJ |
| description |
Introduction
Vitamin D modulates the biosynthesis of neurotransmitters and neurotrophic factors, thus influencing mood and its alterations. Decreased blood levels of Vitamin D are involved in many psychiatric disorders, in particular, affective disorders. As regards bipolar disorder (BD), an association between vitamin D deficiency and severity of illness has been found.
Objectives
In this observational study, we assessed calcium homeostasis imbalance in a sample of patients with BD; in particular, we explored whether serum levels of PTH, Vitamin D and calcium influence the clinical presentation of BD and its symptom severity.
Methods
All patients were administered with validated assessment instruments to assess psychopathology, affective temperaments and global functioning. Vitamin D and PTH levels were assessed in all patients. An-ad hoc schedule was administered for socio-demographic and clinical characteristics.
Results
The total sample consisted of 199 patients (females: 51%; mean age: 47.1 ± 13.2 years). Levels of serum PTH were directly correlated with the total number of hospitalizations (p< 0.01), and of depressive (p< 0.0001), manic (p< 0.001) and hypomanic episodes (p< 0.01). Serum levels of Vitamin D were positively associated with age at first psychiatric contact and were inversely correlated with the total number of depressive episodes (p< 0.05) and cyclothymic temperament (p< 0.05).
Conclusions
Increased levels of PTH and Vit D correlate with a worse clinical outcome of patients with BD. Our results highlight the importance to routinely assess PTH, Vit D and calcium levels in BD patients. Moreover, vitamin D may represent a valid add-on treatment for these patients.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:41:07Z |
| format | Article |
| id | doaj.art-5827d2940967475a850ec63d8185cba7 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:41:07Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-5827d2940967475a850ec63d8185cba72023-11-17T05:08:31ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S81S8110.1192/j.eurpsy.2021.243The role of Vit D and parathyroid hormone in clinical severity of patients with bipolar disorderC. Palummo0L. Marone1V. Caivano2A. Vece3L. Steardo4M. Luciano5A. Di Cerbo6V. Del Vecchio7A. Fiorillo8Department Of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, ItalyDepartment Of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, ItalyDepartment Of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, ItalyDepartment Of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, ItalyHealth Sciences, University Magna Graecia, Catanzaro, ItalyDepartment Of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, ItalyDepartment Of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, ItalyDepartment Of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, ItalyDepartment Of Psychiatry, University of Campania “Luigi Vanvitelli”, Naples, Italy Introduction Vitamin D modulates the biosynthesis of neurotransmitters and neurotrophic factors, thus influencing mood and its alterations. Decreased blood levels of Vitamin D are involved in many psychiatric disorders, in particular, affective disorders. As regards bipolar disorder (BD), an association between vitamin D deficiency and severity of illness has been found. Objectives In this observational study, we assessed calcium homeostasis imbalance in a sample of patients with BD; in particular, we explored whether serum levels of PTH, Vitamin D and calcium influence the clinical presentation of BD and its symptom severity. Methods All patients were administered with validated assessment instruments to assess psychopathology, affective temperaments and global functioning. Vitamin D and PTH levels were assessed in all patients. An-ad hoc schedule was administered for socio-demographic and clinical characteristics. Results The total sample consisted of 199 patients (females: 51%; mean age: 47.1 ± 13.2 years). Levels of serum PTH were directly correlated with the total number of hospitalizations (p< 0.01), and of depressive (p< 0.0001), manic (p< 0.001) and hypomanic episodes (p< 0.01). Serum levels of Vitamin D were positively associated with age at first psychiatric contact and were inversely correlated with the total number of depressive episodes (p< 0.05) and cyclothymic temperament (p< 0.05). Conclusions Increased levels of PTH and Vit D correlate with a worse clinical outcome of patients with BD. Our results highlight the importance to routinely assess PTH, Vit D and calcium levels in BD patients. Moreover, vitamin D may represent a valid add-on treatment for these patients. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933821002431/type/journal_articlebipolar disordervitamin Dsymptomscalcium levels |
| spellingShingle | C. Palummo L. Marone V. Caivano A. Vece L. Steardo M. Luciano A. Di Cerbo V. Del Vecchio A. Fiorillo The role of Vit D and parathyroid hormone in clinical severity of patients with bipolar disorder European Psychiatry bipolar disorder vitamin D symptoms calcium levels |
| title | The role of Vit D and parathyroid hormone in clinical severity of patients with bipolar disorder |
| title_full | The role of Vit D and parathyroid hormone in clinical severity of patients with bipolar disorder |
| title_fullStr | The role of Vit D and parathyroid hormone in clinical severity of patients with bipolar disorder |
| title_full_unstemmed | The role of Vit D and parathyroid hormone in clinical severity of patients with bipolar disorder |
| title_short | The role of Vit D and parathyroid hormone in clinical severity of patients with bipolar disorder |
| title_sort | role of vit d and parathyroid hormone in clinical severity of patients with bipolar disorder |
| topic | bipolar disorder vitamin D symptoms calcium levels |
| url | https://www.cambridge.org/core/product/identifier/S0924933821002431/type/journal_article |
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