Histopathological Evaluation of Gastric Mucosal Atrophy for Predicting Gastric Cancer Risk: Problems and Solutions
Patients suffering from chronic gastritis and developing gastric mucosa atrophy are at increased risk of the development of gastric cancer. The diagnosis of chronic atrophic gastritis (CAG) is a complex procedure involving a detailed history taking, a thorough physical examination and the use of lab...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/15/2478 |
| _version_ | 1797586940349906944 |
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| author | Maria A. Livzan Sergei I. Mozgovoi Olga V. Gaus Anna G. Shimanskaya Alexei V. Kononov |
| author_facet | Maria A. Livzan Sergei I. Mozgovoi Olga V. Gaus Anna G. Shimanskaya Alexei V. Kononov |
| author_sort | Maria A. Livzan |
| collection | DOAJ |
| description | Patients suffering from chronic gastritis and developing gastric mucosa atrophy are at increased risk of the development of gastric cancer. The diagnosis of chronic atrophic gastritis (CAG) is a complex procedure involving a detailed history taking, a thorough physical examination and the use of laboratory and instrumental diagnostic methods among which the endoscopy of the upper digestive tract is the cornerstone because it allows the assessment of the topography of gastritis and identification of erosions and areas of intestinal metaplasia with the use of NBI endoscopy. However, the diagnosis of CAG requires morphological examination of the gastric mucosa. So, in addition to assessing macroscopic changes in the gastric mucosa, it is necessary to take biopsy specimens in accordance with the protocols for their morphological and immunohistochemical examination. In the absence of specific diagnostic stigmas of CAG, close cooperation between a clinician, endoscopist and pathologist is necessary. The article presents systematized data on the histopathological assessment of the gastric mucosa atrophy to predict the risk of gastric cancer. |
| first_indexed | 2024-03-11T00:29:20Z |
| format | Article |
| id | doaj.art-58284ebc7b624e50981c8df87de9c308 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T00:29:20Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-58284ebc7b624e50981c8df87de9c3082023-11-18T22:46:03ZengMDPI AGDiagnostics2075-44182023-07-011315247810.3390/diagnostics13152478Histopathological Evaluation of Gastric Mucosal Atrophy for Predicting Gastric Cancer Risk: Problems and SolutionsMaria A. Livzan0Sergei I. Mozgovoi1Olga V. Gaus2Anna G. Shimanskaya3Alexei V. Kononov4Department of Internal Medicine and Gastroenterology, Omsk Sate Medical University, 644099 Omsk, RussiaDepartment of Pathological Anatomy, Omsk Sate Medical University, 644099 Omsk, RussiaDepartment of Internal Medicine and Gastroenterology, Omsk Sate Medical University, 644099 Omsk, RussiaDepartment of Pathological Anatomy, Omsk Sate Medical University, 644099 Omsk, RussiaDepartment of Pathological Anatomy, Omsk Sate Medical University, 644099 Omsk, RussiaPatients suffering from chronic gastritis and developing gastric mucosa atrophy are at increased risk of the development of gastric cancer. The diagnosis of chronic atrophic gastritis (CAG) is a complex procedure involving a detailed history taking, a thorough physical examination and the use of laboratory and instrumental diagnostic methods among which the endoscopy of the upper digestive tract is the cornerstone because it allows the assessment of the topography of gastritis and identification of erosions and areas of intestinal metaplasia with the use of NBI endoscopy. However, the diagnosis of CAG requires morphological examination of the gastric mucosa. So, in addition to assessing macroscopic changes in the gastric mucosa, it is necessary to take biopsy specimens in accordance with the protocols for their morphological and immunohistochemical examination. In the absence of specific diagnostic stigmas of CAG, close cooperation between a clinician, endoscopist and pathologist is necessary. The article presents systematized data on the histopathological assessment of the gastric mucosa atrophy to predict the risk of gastric cancer.https://www.mdpi.com/2075-4418/13/15/2478chronic atrophic gastritis<i>Helicobacter pylori</i>autoimmune gastritisintestinal metaplasiaOLGA/OLGIMgastric cancer |
| spellingShingle | Maria A. Livzan Sergei I. Mozgovoi Olga V. Gaus Anna G. Shimanskaya Alexei V. Kononov Histopathological Evaluation of Gastric Mucosal Atrophy for Predicting Gastric Cancer Risk: Problems and Solutions Diagnostics chronic atrophic gastritis <i>Helicobacter pylori</i> autoimmune gastritis intestinal metaplasia OLGA/OLGIM gastric cancer |
| title | Histopathological Evaluation of Gastric Mucosal Atrophy for Predicting Gastric Cancer Risk: Problems and Solutions |
| title_full | Histopathological Evaluation of Gastric Mucosal Atrophy for Predicting Gastric Cancer Risk: Problems and Solutions |
| title_fullStr | Histopathological Evaluation of Gastric Mucosal Atrophy for Predicting Gastric Cancer Risk: Problems and Solutions |
| title_full_unstemmed | Histopathological Evaluation of Gastric Mucosal Atrophy for Predicting Gastric Cancer Risk: Problems and Solutions |
| title_short | Histopathological Evaluation of Gastric Mucosal Atrophy for Predicting Gastric Cancer Risk: Problems and Solutions |
| title_sort | histopathological evaluation of gastric mucosal atrophy for predicting gastric cancer risk problems and solutions |
| topic | chronic atrophic gastritis <i>Helicobacter pylori</i> autoimmune gastritis intestinal metaplasia OLGA/OLGIM gastric cancer |
| url | https://www.mdpi.com/2075-4418/13/15/2478 |
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