BRAF V600E -mutated serrated colorectal neoplasia drives transcriptional activation of cholesterol metabolism
Abstract BRAF mutations occur early in serrated colorectal cancers, but their long-term influence on tissue homeostasis is poorly characterized. We investigated the impact of short-term (3 days) and long-term (6 months) expression of Braf V600E in the intestinal tissue of an inducible mouse model. W...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-09-01
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Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-023-05331-x |