Whole-Body Regeneration in the Lobate Ctenophore <i>Mnemiopsis leidyi</i>
Ctenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus <i>Beroe</i> having completely lost...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Genes |
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| Online Access: | https://www.mdpi.com/2073-4425/12/6/867 |
| _version_ | 1797531234195210240 |
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| author | Allison Edgar Dorothy G. Mitchell Mark Q. Martindale |
| author_facet | Allison Edgar Dorothy G. Mitchell Mark Q. Martindale |
| author_sort | Allison Edgar |
| collection | DOAJ |
| description | Ctenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus <i>Beroe</i> having completely lost the ability to replace missing body parts. We focus on the unique regenerative aspects of the lobate ctenophore, <i>Mnemiopsis leidyi</i>, which has become a popular model for its rapid wound healing and tissue replacement, optical clarity, and sequenced genome. <i>M. leidyi</i>’s highly mosaic, stereotyped development has been leveraged to reveal the polar coordinate system that directs whole-body regeneration as well as lineage restriction of replacement cells in various regenerating organs. Several cell signaling pathways known to function in regeneration in other animals are absent from the ctenophore’s genome. Further research will either reveal ancient principles of the regenerative process common to all animals or reveal novel solutions to the stability of cell fates and whole-body regeneration. |
| first_indexed | 2024-03-10T10:40:56Z |
| format | Article |
| id | doaj.art-5828f2555c4449b981c3abf822624b7e |
| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-10T10:40:56Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Genes |
| spelling | doaj.art-5828f2555c4449b981c3abf822624b7e2023-11-21T22:56:11ZengMDPI AGGenes2073-44252021-06-0112686710.3390/genes12060867Whole-Body Regeneration in the Lobate Ctenophore <i>Mnemiopsis leidyi</i>Allison Edgar0Dorothy G. Mitchell1Mark Q. Martindale2The Whitney Laboratory for Marine Bioscience, 9505 N, Ocean Shore Blvd, St. Augustine, FL 32080-8610, USAThe Whitney Laboratory for Marine Bioscience, 9505 N, Ocean Shore Blvd, St. Augustine, FL 32080-8610, USAThe Whitney Laboratory for Marine Bioscience, 9505 N, Ocean Shore Blvd, St. Augustine, FL 32080-8610, USACtenophores (a.k.a. comb jellies) are one of the earliest branching extant metazoan phyla. Adult regenerative ability varies greatly within the group, with platyctenes undergoing both sexual and asexual reproduction by fission while others in the genus <i>Beroe</i> having completely lost the ability to replace missing body parts. We focus on the unique regenerative aspects of the lobate ctenophore, <i>Mnemiopsis leidyi</i>, which has become a popular model for its rapid wound healing and tissue replacement, optical clarity, and sequenced genome. <i>M. leidyi</i>’s highly mosaic, stereotyped development has been leveraged to reveal the polar coordinate system that directs whole-body regeneration as well as lineage restriction of replacement cells in various regenerating organs. Several cell signaling pathways known to function in regeneration in other animals are absent from the ctenophore’s genome. Further research will either reveal ancient principles of the regenerative process common to all animals or reveal novel solutions to the stability of cell fates and whole-body regeneration.https://www.mdpi.com/2073-4425/12/6/867ctenophoreregeneration<i>Mnemiopsis leidyi</i> |
| spellingShingle | Allison Edgar Dorothy G. Mitchell Mark Q. Martindale Whole-Body Regeneration in the Lobate Ctenophore <i>Mnemiopsis leidyi</i> Genes ctenophore regeneration <i>Mnemiopsis leidyi</i> |
| title | Whole-Body Regeneration in the Lobate Ctenophore <i>Mnemiopsis leidyi</i> |
| title_full | Whole-Body Regeneration in the Lobate Ctenophore <i>Mnemiopsis leidyi</i> |
| title_fullStr | Whole-Body Regeneration in the Lobate Ctenophore <i>Mnemiopsis leidyi</i> |
| title_full_unstemmed | Whole-Body Regeneration in the Lobate Ctenophore <i>Mnemiopsis leidyi</i> |
| title_short | Whole-Body Regeneration in the Lobate Ctenophore <i>Mnemiopsis leidyi</i> |
| title_sort | whole body regeneration in the lobate ctenophore i mnemiopsis leidyi i |
| topic | ctenophore regeneration <i>Mnemiopsis leidyi</i> |
| url | https://www.mdpi.com/2073-4425/12/6/867 |
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