Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017
Abstract Background The aim of this study was to provide information on the semen quality pattern of infertile men and age thresholds for semen parameters in China. Methods This was a retrospective cross-sectional study investigating 71,623 infertile men from the Reproductive and Genetic Hospital of...
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | Reproductive Biology and Endocrinology |
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| Online Access: | https://doi.org/10.1186/s12958-019-0551-2 |
| _version_ | 1818352673906229248 |
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| author | W. N. Li M. M. Jia Y. Q. Peng R. Ding L. Q. Fan G. Liu |
| author_facet | W. N. Li M. M. Jia Y. Q. Peng R. Ding L. Q. Fan G. Liu |
| author_sort | W. N. Li |
| collection | DOAJ |
| description | Abstract Background The aim of this study was to provide information on the semen quality pattern of infertile men and age thresholds for semen parameters in China. Methods This was a retrospective cross-sectional study investigating 71,623 infertile men from the Reproductive and Genetic Hospital of CITIC Xiangya in Hunan, China, from 2011 to 2017. The Kruskal-Wallis test, Mann-Kendall test, linear regression model and joinpoint regression were used. Results Although erratic changes were observed in the median semen parameters (sperm concentration 40.1–52.1 × 106/ml, total sperm count 117.8–153.1 × 106, sperm progressive motility 33.4–38.1%) during the 7 years of observation, no significant decrease in semen quality was found, and 47.88% of infertile men showed normal semen parameters according to the World Health Organization (WHO) criteria. According to the joinpoint regression analysis, sperm progressive motility appeared to decrease earlier than the sperm concentration and total sperm count (at 28, 58, and 42 years of age, respectively). Conclusions There is no evidence of a deterioration in semen quality among infertile men in Hunan, China. Semen parameters decreased with increasing age, with turning points noted at different ages. Semen parameters are not absolute evidence for the assessment of male fertility potential. Therefore, we believe that, among semen parameters, the sperm concentration is the best predictor of fertility for ART, followed by motility. Decreased sperm motility may affect natural pregnancy, but it is not necessary for successful IVF. |
| first_indexed | 2024-12-13T18:57:23Z |
| format | Article |
| id | doaj.art-5829d183cee541d6ab2baeb995fdb820 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-13T18:57:23Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-5829d183cee541d6ab2baeb995fdb8202022-12-21T23:34:46ZengBMCReproductive Biology and Endocrinology1477-78272019-12-011711810.1186/s12958-019-0551-2Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017W. N. Li0M. M. Jia1Y. Q. Peng2R. Ding3L. Q. Fan4G. Liu5The Institute of Reproduction and Stem Cell Engineering, Central South UniversityNorthwest Women’s and Children’s HospitalReproductive and Genetic Hospital of CITIC-XiangyaThe Institute of Reproduction and Stem Cell Engineering, Central South UniversityThe Institute of Reproduction and Stem Cell Engineering, Central South UniversityThe Institute of Reproduction and Stem Cell Engineering, Central South UniversityAbstract Background The aim of this study was to provide information on the semen quality pattern of infertile men and age thresholds for semen parameters in China. Methods This was a retrospective cross-sectional study investigating 71,623 infertile men from the Reproductive and Genetic Hospital of CITIC Xiangya in Hunan, China, from 2011 to 2017. The Kruskal-Wallis test, Mann-Kendall test, linear regression model and joinpoint regression were used. Results Although erratic changes were observed in the median semen parameters (sperm concentration 40.1–52.1 × 106/ml, total sperm count 117.8–153.1 × 106, sperm progressive motility 33.4–38.1%) during the 7 years of observation, no significant decrease in semen quality was found, and 47.88% of infertile men showed normal semen parameters according to the World Health Organization (WHO) criteria. According to the joinpoint regression analysis, sperm progressive motility appeared to decrease earlier than the sperm concentration and total sperm count (at 28, 58, and 42 years of age, respectively). Conclusions There is no evidence of a deterioration in semen quality among infertile men in Hunan, China. Semen parameters decreased with increasing age, with turning points noted at different ages. Semen parameters are not absolute evidence for the assessment of male fertility potential. Therefore, we believe that, among semen parameters, the sperm concentration is the best predictor of fertility for ART, followed by motility. Decreased sperm motility may affect natural pregnancy, but it is not necessary for successful IVF.https://doi.org/10.1186/s12958-019-0551-2Infertile menSemen parametersSemen qualityAge threshold |
| spellingShingle | W. N. Li M. M. Jia Y. Q. Peng R. Ding L. Q. Fan G. Liu Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017 Reproductive Biology and Endocrinology Infertile men Semen parameters Semen quality Age threshold |
| title | Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017 |
| title_full | Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017 |
| title_fullStr | Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017 |
| title_full_unstemmed | Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017 |
| title_short | Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017 |
| title_sort | semen quality pattern and age threshold a retrospective cross sectional study of 71 623 infertile men in china between 2011 and 2017 |
| topic | Infertile men Semen parameters Semen quality Age threshold |
| url | https://doi.org/10.1186/s12958-019-0551-2 |
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