Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining.
DNA double-strand breaks (DSBs) are one of the most dangerous forms of DNA lesion that can result in genomic instability and cell death. Therefore cells have developed elaborate DSB-repair pathways to maintain the integrity of genomic DNA. There are two major pathways for the repair of DSBs in eukar...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2006-02-01
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| Series: | PLoS Genetics |
| Online Access: | https://doi.org/10.1371/journal.pgen.0020008 |
| _version_ | 1819029804070993920 |
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| author | Richard Bowater Aidan J Doherty |
| author_facet | Richard Bowater Aidan J Doherty |
| author_sort | Richard Bowater |
| collection | DOAJ |
| description | DNA double-strand breaks (DSBs) are one of the most dangerous forms of DNA lesion that can result in genomic instability and cell death. Therefore cells have developed elaborate DSB-repair pathways to maintain the integrity of genomic DNA. There are two major pathways for the repair of DSBs in eukaryotes: homologous recombination and non-homologous end-joining (NHEJ). Until very recently, the NHEJ pathway had been thought to be restricted to the eukarya. However, an evolutionarily related NHEJ apparatus has now been identified and characterized in the prokarya. Here we review the recent discoveries concerning bacterial NHEJ and discuss the possible origins of this repair system. We also examine the insights gained from the recent cellular and biochemical studies of this DSB-repair process and discuss the possible cellular roles of an NHEJ pathway in the life-cycle of prokaryotes and phages. |
| first_indexed | 2024-12-21T06:20:04Z |
| format | Article |
| id | doaj.art-582b59c9d70d4f3c91dcf003a5e0a130 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-12-21T06:20:04Z |
| publishDate | 2006-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-582b59c9d70d4f3c91dcf003a5e0a1302022-12-21T19:13:16ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042006-02-0122e810.1371/journal.pgen.0020008Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining.Richard BowaterAidan J DohertyDNA double-strand breaks (DSBs) are one of the most dangerous forms of DNA lesion that can result in genomic instability and cell death. Therefore cells have developed elaborate DSB-repair pathways to maintain the integrity of genomic DNA. There are two major pathways for the repair of DSBs in eukaryotes: homologous recombination and non-homologous end-joining (NHEJ). Until very recently, the NHEJ pathway had been thought to be restricted to the eukarya. However, an evolutionarily related NHEJ apparatus has now been identified and characterized in the prokarya. Here we review the recent discoveries concerning bacterial NHEJ and discuss the possible origins of this repair system. We also examine the insights gained from the recent cellular and biochemical studies of this DSB-repair process and discuss the possible cellular roles of an NHEJ pathway in the life-cycle of prokaryotes and phages.https://doi.org/10.1371/journal.pgen.0020008 |
| spellingShingle | Richard Bowater Aidan J Doherty Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. PLoS Genetics |
| title | Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. |
| title_full | Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. |
| title_fullStr | Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. |
| title_full_unstemmed | Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. |
| title_short | Making ends meet: repairing breaks in bacterial DNA by non-homologous end-joining. |
| title_sort | making ends meet repairing breaks in bacterial dna by non homologous end joining |
| url | https://doi.org/10.1371/journal.pgen.0020008 |
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