In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review
Background: Invasive dental treatment in patients exposed to antiresorptive and antiangiogenic drugs can cause medication-related osteonecrosis of the jaw (MRONJ). Currently, the exact pathogenesis of this disease is unclear. Methods: In March 2022, Medline (Ovid), Embase (Ovid), Scopus, and Web of...
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| Format: | Article |
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MDPI AG
2023-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/13/6/973 |
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| author | Robert H. Guirguis Leonard P. Tan Rebecca M. Hicks Aniqa Hasan Tina D. Duong Xia Hu Jordan Y. S. Hng Mohammad H. Hadi Henry C. Owuama Tamara Matthyssen Michael McCullough Federica Canfora Rita Paolini Antonio Celentano |
| author_facet | Robert H. Guirguis Leonard P. Tan Rebecca M. Hicks Aniqa Hasan Tina D. Duong Xia Hu Jordan Y. S. Hng Mohammad H. Hadi Henry C. Owuama Tamara Matthyssen Michael McCullough Federica Canfora Rita Paolini Antonio Celentano |
| author_sort | Robert H. Guirguis |
| collection | DOAJ |
| description | Background: Invasive dental treatment in patients exposed to antiresorptive and antiangiogenic drugs can cause medication-related osteonecrosis of the jaw (MRONJ). Currently, the exact pathogenesis of this disease is unclear. Methods: In March 2022, Medline (Ovid), Embase (Ovid), Scopus, and Web of Science were screened to identify eligible in vitro studies investigating the effects of antiresorptive and antiangiogenic compounds on orally derived cells. Results: Fifty-nine articles met the inclusion criteria. Bisphosphonates were used in 57 studies, denosumab in two, and sunitinib and bevacizumab in one. Zoledronate was the most commonly used nitrogen-containing bisphosphonate. The only non-nitrogen-containing bisphosphonate studied was clodronate. The most frequently tested tissues were gingival fibroblasts, oral keratinocytes, and alveolar osteoblasts. These drugs caused a decrease in cell proliferation, viability, and migration. Conclusions: Antiresorptive and antiangiogenic drugs displayed cytotoxic effects in a dose and time-dependent manner. Additional research is required to further elucidate the pathways of MRONJ. |
| first_indexed | 2024-03-11T02:41:42Z |
| format | Article |
| id | doaj.art-582cc19bd4e141818a190de62109d293 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T02:41:42Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-582cc19bd4e141818a190de62109d2932023-11-18T09:31:23ZengMDPI AGBiomolecules2218-273X2023-06-0113697310.3390/biom13060973In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic ReviewRobert H. Guirguis0Leonard P. Tan1Rebecca M. Hicks2Aniqa Hasan3Tina D. Duong4Xia Hu5Jordan Y. S. Hng6Mohammad H. Hadi7Henry C. Owuama8Tamara Matthyssen9Michael McCullough10Federica Canfora11Rita Paolini12Antonio Celentano13Melbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaDepartment of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, 80131 Naples, ItalyMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaMelbourne Dental School, The University of Melbourne, 720 Swanston Street, Carlton, VIC 3053, AustraliaBackground: Invasive dental treatment in patients exposed to antiresorptive and antiangiogenic drugs can cause medication-related osteonecrosis of the jaw (MRONJ). Currently, the exact pathogenesis of this disease is unclear. Methods: In March 2022, Medline (Ovid), Embase (Ovid), Scopus, and Web of Science were screened to identify eligible in vitro studies investigating the effects of antiresorptive and antiangiogenic compounds on orally derived cells. Results: Fifty-nine articles met the inclusion criteria. Bisphosphonates were used in 57 studies, denosumab in two, and sunitinib and bevacizumab in one. Zoledronate was the most commonly used nitrogen-containing bisphosphonate. The only non-nitrogen-containing bisphosphonate studied was clodronate. The most frequently tested tissues were gingival fibroblasts, oral keratinocytes, and alveolar osteoblasts. These drugs caused a decrease in cell proliferation, viability, and migration. Conclusions: Antiresorptive and antiangiogenic drugs displayed cytotoxic effects in a dose and time-dependent manner. Additional research is required to further elucidate the pathways of MRONJ.https://www.mdpi.com/2218-273X/13/6/973MRONJbisphosphonatesantiresorptivesantiangiogenicsoral tissues |
| spellingShingle | Robert H. Guirguis Leonard P. Tan Rebecca M. Hicks Aniqa Hasan Tina D. Duong Xia Hu Jordan Y. S. Hng Mohammad H. Hadi Henry C. Owuama Tamara Matthyssen Michael McCullough Federica Canfora Rita Paolini Antonio Celentano In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review Biomolecules MRONJ bisphosphonates antiresorptives antiangiogenics oral tissues |
| title | In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review |
| title_full | In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review |
| title_fullStr | In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review |
| title_full_unstemmed | In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review |
| title_short | In Vitro Cytotoxicity of Antiresorptive and Antiangiogenic Compounds on Oral Tissues Contributing to MRONJ: Systematic Review |
| title_sort | in vitro cytotoxicity of antiresorptive and antiangiogenic compounds on oral tissues contributing to mronj systematic review |
| topic | MRONJ bisphosphonates antiresorptives antiangiogenics oral tissues |
| url | https://www.mdpi.com/2218-273X/13/6/973 |
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