Microbial Resistance to Antibiotics and Effective Antibiotherapy
Currently, the efficacy of antibiotics is severely affected by the emergence of the antimicrobial resistance phenomenon, leading to increased morbidity and mortality worldwide. Multidrug-resistant pathogens are found not only in hospital settings, but also in the community, and are considered one of...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/5/1121 |
| _version_ | 1827670110331994112 |
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| author | Adriana Aurelia Chiș Luca Liviu Rus Claudiu Morgovan Anca Maria Arseniu Adina Frum Andreea Loredana Vonica-Țincu Felicia Gabriela Gligor Maria Lucia Mureșan Carmen Maximiliana Dobrea |
| author_facet | Adriana Aurelia Chiș Luca Liviu Rus Claudiu Morgovan Anca Maria Arseniu Adina Frum Andreea Loredana Vonica-Țincu Felicia Gabriela Gligor Maria Lucia Mureșan Carmen Maximiliana Dobrea |
| author_sort | Adriana Aurelia Chiș |
| collection | DOAJ |
| description | Currently, the efficacy of antibiotics is severely affected by the emergence of the antimicrobial resistance phenomenon, leading to increased morbidity and mortality worldwide. Multidrug-resistant pathogens are found not only in hospital settings, but also in the community, and are considered one of the biggest public health concerns. The main mechanisms by which bacteria develop resistance to antibiotics include changes in the drug target, prevention of entering the cell, elimination through efflux pumps or inactivation of drugs. A better understanding and prediction of resistance patterns of a pathogen will lead to a better selection of active antibiotics for the treatment of multidrug-resistant infections. |
| first_indexed | 2024-03-10T03:17:26Z |
| format | Article |
| id | doaj.art-582d6d5924c34c59a99b00b3438438cb |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T03:17:26Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-582d6d5924c34c59a99b00b3438438cb2023-11-23T10:11:19ZengMDPI AGBiomedicines2227-90592022-05-01105112110.3390/biomedicines10051121Microbial Resistance to Antibiotics and Effective AntibiotherapyAdriana Aurelia Chiș0Luca Liviu Rus1Claudiu Morgovan2Anca Maria Arseniu3Adina Frum4Andreea Loredana Vonica-Țincu5Felicia Gabriela Gligor6Maria Lucia Mureșan7Carmen Maximiliana Dobrea8Preclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaPreclinical Department, Faculty of Medicine, “Lucian Blaga” University of Sibiu, 550169 Sibiu, RomaniaCurrently, the efficacy of antibiotics is severely affected by the emergence of the antimicrobial resistance phenomenon, leading to increased morbidity and mortality worldwide. Multidrug-resistant pathogens are found not only in hospital settings, but also in the community, and are considered one of the biggest public health concerns. The main mechanisms by which bacteria develop resistance to antibiotics include changes in the drug target, prevention of entering the cell, elimination through efflux pumps or inactivation of drugs. A better understanding and prediction of resistance patterns of a pathogen will lead to a better selection of active antibiotics for the treatment of multidrug-resistant infections.https://www.mdpi.com/2227-9059/10/5/1121antibiotic resistancemultidrug-resistant bacteriamechanism of resistancepersistencebiofilmsantibiotherapy |
| spellingShingle | Adriana Aurelia Chiș Luca Liviu Rus Claudiu Morgovan Anca Maria Arseniu Adina Frum Andreea Loredana Vonica-Țincu Felicia Gabriela Gligor Maria Lucia Mureșan Carmen Maximiliana Dobrea Microbial Resistance to Antibiotics and Effective Antibiotherapy Biomedicines antibiotic resistance multidrug-resistant bacteria mechanism of resistance persistence biofilms antibiotherapy |
| title | Microbial Resistance to Antibiotics and Effective Antibiotherapy |
| title_full | Microbial Resistance to Antibiotics and Effective Antibiotherapy |
| title_fullStr | Microbial Resistance to Antibiotics and Effective Antibiotherapy |
| title_full_unstemmed | Microbial Resistance to Antibiotics and Effective Antibiotherapy |
| title_short | Microbial Resistance to Antibiotics and Effective Antibiotherapy |
| title_sort | microbial resistance to antibiotics and effective antibiotherapy |
| topic | antibiotic resistance multidrug-resistant bacteria mechanism of resistance persistence biofilms antibiotherapy |
| url | https://www.mdpi.com/2227-9059/10/5/1121 |
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