Meta-analysis of validity of echogenic intracardiac foci for calculating the risk of Down syndrome in the second trimester of pregnancy
Echogenic intracardiac foci are a second trimester marker associated with aneuploidy in high-risk populations. The objective of this study is to assess the validity of echogenic intracardiac foci for Down syndrome detection in the second trimester ultrasound scan. A systematic search in major biblio...
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| Format: | Article |
| Language: | English |
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Elsevier
2017-02-01
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| Series: | Taiwanese Journal of Obstetrics & Gynecology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1028455916302273 |
| _version_ | 1818544683341578240 |
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| author | Ana María Rubio Lorente María Moreno-Cid María José Rodríguez Gema Bueno José María Tenías Carmen Román Ángel Arias Ana Pascual |
| author_facet | Ana María Rubio Lorente María Moreno-Cid María José Rodríguez Gema Bueno José María Tenías Carmen Román Ángel Arias Ana Pascual |
| author_sort | Ana María Rubio Lorente |
| collection | DOAJ |
| description | Echogenic intracardiac foci are a second trimester marker associated with aneuploidy in high-risk populations. The objective of this study is to assess the validity of echogenic intracardiac foci for Down syndrome detection in the second trimester ultrasound scan. A systematic search in major bibliographic databases was carried out (MEDLINE, EMBASE, CINAHL). Twenty-five studies about echogenic intracardiac foci were selected for statistical synthesis in this systematic review. Those 25 considered to be relevant were then subjected to critical reading, following the Critical Appraisal Skills Programme criteria, by at least three independent observers. Then, the published articles were subjected to a meta-analysis. A global sensitivity of 21.8% and a 4.1% false positive rate were obtained. The positive likelihood ratio was 5.08 (95% confidence interval, 4.04–6.41). The subgroups analysis did not reveal statistically significant differences. In conclusion, echogenic intracardiac foci as an isolated marker could be a tool to identify—rather than exclude—the high-risk group of Down syndrome, although it should be noted that it shows low sensitivity. |
| first_indexed | 2024-12-11T22:51:38Z |
| format | Article |
| id | doaj.art-582dcda5348c4eddaa399991dd9508a5 |
| institution | Directory Open Access Journal |
| issn | 1028-4559 |
| language | English |
| last_indexed | 2024-12-11T22:51:38Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Taiwanese Journal of Obstetrics & Gynecology |
| spelling | doaj.art-582dcda5348c4eddaa399991dd9508a52022-12-22T00:47:24ZengElsevierTaiwanese Journal of Obstetrics & Gynecology1028-45592017-02-01561162210.1016/j.tjog.2016.11.002Meta-analysis of validity of echogenic intracardiac foci for calculating the risk of Down syndrome in the second trimester of pregnancyAna María Rubio Lorente0María Moreno-Cid1María José Rodríguez2Gema Bueno3José María Tenías4Carmen Román5Ángel Arias6Ana Pascual7Obstetrics and Gynaecology Department, Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, SpainObstetrics and Gynaecology Department, Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, SpainObstetrics and Gynaecology Department, Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, SpainObstetrics and Gynaecology Department, Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, SpainResearch Support Unit, Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, SpainResearch Support Unit, Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, SpainResearch Support Unit, Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, SpainObstetrics and Gynaecology Department, Hospital La Mancha Centro, Alcázar de San Juan, Ciudad Real, SpainEchogenic intracardiac foci are a second trimester marker associated with aneuploidy in high-risk populations. The objective of this study is to assess the validity of echogenic intracardiac foci for Down syndrome detection in the second trimester ultrasound scan. A systematic search in major bibliographic databases was carried out (MEDLINE, EMBASE, CINAHL). Twenty-five studies about echogenic intracardiac foci were selected for statistical synthesis in this systematic review. Those 25 considered to be relevant were then subjected to critical reading, following the Critical Appraisal Skills Programme criteria, by at least three independent observers. Then, the published articles were subjected to a meta-analysis. A global sensitivity of 21.8% and a 4.1% false positive rate were obtained. The positive likelihood ratio was 5.08 (95% confidence interval, 4.04–6.41). The subgroups analysis did not reveal statistically significant differences. In conclusion, echogenic intracardiac foci as an isolated marker could be a tool to identify—rather than exclude—the high-risk group of Down syndrome, although it should be noted that it shows low sensitivity.http://www.sciencedirect.com/science/article/pii/S1028455916302273Downechogenic focusintracardiacmeta-analysisscreening |
| spellingShingle | Ana María Rubio Lorente María Moreno-Cid María José Rodríguez Gema Bueno José María Tenías Carmen Román Ángel Arias Ana Pascual Meta-analysis of validity of echogenic intracardiac foci for calculating the risk of Down syndrome in the second trimester of pregnancy Taiwanese Journal of Obstetrics & Gynecology Down echogenic focus intracardiac meta-analysis screening |
| title | Meta-analysis of validity of echogenic intracardiac foci for calculating the risk of Down syndrome in the second trimester of pregnancy |
| title_full | Meta-analysis of validity of echogenic intracardiac foci for calculating the risk of Down syndrome in the second trimester of pregnancy |
| title_fullStr | Meta-analysis of validity of echogenic intracardiac foci for calculating the risk of Down syndrome in the second trimester of pregnancy |
| title_full_unstemmed | Meta-analysis of validity of echogenic intracardiac foci for calculating the risk of Down syndrome in the second trimester of pregnancy |
| title_short | Meta-analysis of validity of echogenic intracardiac foci for calculating the risk of Down syndrome in the second trimester of pregnancy |
| title_sort | meta analysis of validity of echogenic intracardiac foci for calculating the risk of down syndrome in the second trimester of pregnancy |
| topic | Down echogenic focus intracardiac meta-analysis screening |
| url | http://www.sciencedirect.com/science/article/pii/S1028455916302273 |
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