<i>In Silico</i> Investigation of the Biological Implications of Complex DNA Damage with Emphasis in Cancer Radiotherapy through a Systems Biology Approach

<i>In Silico</i> Investigation of the Biological Implications of Complex DNA Damage with Emphasis in Cancer Radiotherapy through a Systems Biology Approach

Different types of DNA lesions forming in close vicinity, create clusters of damaged sites termed as “clustered/complex DNA damage” and they are considered to be a major challenge for DNA repair mechanisms resulting in significant repair delays and induction of genomic instability. Upon detection of...

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Bibliographic Details
Main Authors: Athanasia Pavlopoulou, Seyedehsadaf Asfa, Evangelos Gioukakis, Ifigeneia V. Mavragani, Zacharenia Nikitaki, Işıl Takan, Jean-Pierre Pouget, Lynn Harrison, Alexandros G. Georgakilas
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Molecules
Subjects:
clustered DNA damage
ionizing radiation
cancer
comorbidities
prognosis
systems biology
Online Access:https://www.mdpi.com/1420-3049/26/24/7602

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