mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass
Maintenance of skeletal muscle mass is regulated by the balance between anabolic and catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase, and is known to play vital roles in protein synthesis. Recent findings have continued to refine our u...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-10-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00788/full |
| _version_ | 1818020580293607424 |
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| author | Mee-Sup Yoon |
| author_facet | Mee-Sup Yoon |
| author_sort | Mee-Sup Yoon |
| collection | DOAJ |
| description | Maintenance of skeletal muscle mass is regulated by the balance between anabolic and catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase, and is known to play vital roles in protein synthesis. Recent findings have continued to refine our understanding of the function of mTOR in maintaining skeletal muscle mass. mTOR controls the anabolic and catabolic signaling of skeletal muscle mass, resulting in the modulation of muscle hypertrophy and muscle wastage. This review will highlight the fundamental role of mTOR in skeletal muscle growth by summarizing the phenotype of skeletal-specific mTOR deficiency. In addition, the evidence that mTOR is a dual regulator of anabolism and catabolism in skeletal muscle mass will be discussed. A full understanding of mTOR signaling in the maintenance of skeletal muscle mass could help to develop mTOR-targeted therapeutics to prevent muscle wasting. |
| first_indexed | 2024-04-14T08:07:02Z |
| format | Article |
| id | doaj.art-58333d1b130a4545ae921f8f00db5358 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-14T08:07:02Z |
| publishDate | 2017-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-58333d1b130a4545ae921f8f00db53582022-12-22T02:04:41ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-10-01810.3389/fphys.2017.00788294538mTOR as a Key Regulator in Maintaining Skeletal Muscle MassMee-Sup YoonMaintenance of skeletal muscle mass is regulated by the balance between anabolic and catabolic processes. Mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase, and is known to play vital roles in protein synthesis. Recent findings have continued to refine our understanding of the function of mTOR in maintaining skeletal muscle mass. mTOR controls the anabolic and catabolic signaling of skeletal muscle mass, resulting in the modulation of muscle hypertrophy and muscle wastage. This review will highlight the fundamental role of mTOR in skeletal muscle growth by summarizing the phenotype of skeletal-specific mTOR deficiency. In addition, the evidence that mTOR is a dual regulator of anabolism and catabolism in skeletal muscle mass will be discussed. A full understanding of mTOR signaling in the maintenance of skeletal muscle mass could help to develop mTOR-targeted therapeutics to prevent muscle wasting.http://journal.frontiersin.org/article/10.3389/fphys.2017.00788/fullmTORskeletal musclehypertrophyatrophysarcopenia |
| spellingShingle | Mee-Sup Yoon mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass Frontiers in Physiology mTOR skeletal muscle hypertrophy atrophy sarcopenia |
| title | mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass |
| title_full | mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass |
| title_fullStr | mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass |
| title_full_unstemmed | mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass |
| title_short | mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass |
| title_sort | mtor as a key regulator in maintaining skeletal muscle mass |
| topic | mTOR skeletal muscle hypertrophy atrophy sarcopenia |
| url | http://journal.frontiersin.org/article/10.3389/fphys.2017.00788/full |
| work_keys_str_mv | AT meesupyoon mtorasakeyregulatorinmaintainingskeletalmusclemass |