Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function

Abstract Background Exposure to polycyclic aromatic hydrocarbons (PAHs) is related to decreased lung function. However, whether oxidative damage is involved in this relationship remains unclear. This study was aimed to explore the potential mediating role of oxidative DNA or lipid damage in the asso...

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Main Authors: Limin Cao, Yun Zhou, Aijun Tan, Tingming Shi, Chunmei Zhu, Lili Xiao, Zhuang Zhang, Shijie Yang, Ge Mu, Xing Wang, Dongming Wang, Jixuan Ma, Weihong Chen
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Environmental Health
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12940-020-00621-x
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author Limin Cao
Yun Zhou
Aijun Tan
Tingming Shi
Chunmei Zhu
Lili Xiao
Zhuang Zhang
Shijie Yang
Ge Mu
Xing Wang
Dongming Wang
Jixuan Ma
Weihong Chen
author_facet Limin Cao
Yun Zhou
Aijun Tan
Tingming Shi
Chunmei Zhu
Lili Xiao
Zhuang Zhang
Shijie Yang
Ge Mu
Xing Wang
Dongming Wang
Jixuan Ma
Weihong Chen
author_sort Limin Cao
collection DOAJ
description Abstract Background Exposure to polycyclic aromatic hydrocarbons (PAHs) is related to decreased lung function. However, whether oxidative damage is involved in this relationship remains unclear. This study was aimed to explore the potential mediating role of oxidative DNA or lipid damage in the association between PAH exposure and lung function. Methods The urinary levels of monohydroxy polycyclic aromatic hydrocarbon metabolites (OH-PAHs) and lung function parameters were measured among 3367 participants from the baseline of the Wuhan-Zhuhai cohort. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-isoprostane (8-iso-PGF2α) were determined to evaluate the individuals’ oxidative DNA and lipid damage degrees, respectively. Linear mixed models were used to investigate the associations of urinary OH-PAHs, 8-OHdG and 8-iso-PGF2α with lung function parameters. Mediation analysis was further conducted to assess the potential role of oxidative damage in the association between urinary OH-PAHs and lung function. Results Each one-percentage increase in the sum of urinary OH-PAHs, high-molecular-weight or low-molecular-weight OH-PAHs (ƩOH-PAHs, ƩHMW OH-PAH or ƩLMW OH-PAHs, respectively) was associated with a 0.2152-, 0.2076- or 0.1985- ml decrease in FEV1, and a 0.1891-, 0.2195- or 0.1634- ml decrease in FVC, respectively. Additionally, significantly positive dose-response relationships of ƩOH-PAHs, ƩHMW OH-PAH and ƩLMW OH-PAHs with urinary 8-OHdG or 8-iso-PGF2α, as well as an inverse dose-response relationship between urinary 8-OHdG and FVC, were observed (all P for trend < 0.05). Mediation analysis indicated that urinary 8-OHdG mediated 14.22% of the association between ƩHMW OH-PAH and FVC. Conclusion Higher levels of oxidative DNA damage might be involved in the decreased levels of FVC caused by high-molecular-weight PAH exposure.
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spelling doaj.art-58334946e9d04c61aa61ea2d5328c3d02022-12-21T18:37:55ZengBMCEnvironmental Health1476-069X2020-07-0119111010.1186/s12940-020-00621-xOxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung functionLimin Cao0Yun Zhou1Aijun Tan2Tingming Shi3Chunmei Zhu4Lili Xiao5Zhuang Zhang6Shijie Yang7Ge Mu8Xing Wang9Dongming Wang10Jixuan Ma11Weihong Chen12Department of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyZhuhai Center for Disease Control and PreventionHubei Center for Disease Control and PreventionDepartment of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Occupational & Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background Exposure to polycyclic aromatic hydrocarbons (PAHs) is related to decreased lung function. However, whether oxidative damage is involved in this relationship remains unclear. This study was aimed to explore the potential mediating role of oxidative DNA or lipid damage in the association between PAH exposure and lung function. Methods The urinary levels of monohydroxy polycyclic aromatic hydrocarbon metabolites (OH-PAHs) and lung function parameters were measured among 3367 participants from the baseline of the Wuhan-Zhuhai cohort. Urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and 8-isoprostane (8-iso-PGF2α) were determined to evaluate the individuals’ oxidative DNA and lipid damage degrees, respectively. Linear mixed models were used to investigate the associations of urinary OH-PAHs, 8-OHdG and 8-iso-PGF2α with lung function parameters. Mediation analysis was further conducted to assess the potential role of oxidative damage in the association between urinary OH-PAHs and lung function. Results Each one-percentage increase in the sum of urinary OH-PAHs, high-molecular-weight or low-molecular-weight OH-PAHs (ƩOH-PAHs, ƩHMW OH-PAH or ƩLMW OH-PAHs, respectively) was associated with a 0.2152-, 0.2076- or 0.1985- ml decrease in FEV1, and a 0.1891-, 0.2195- or 0.1634- ml decrease in FVC, respectively. Additionally, significantly positive dose-response relationships of ƩOH-PAHs, ƩHMW OH-PAH and ƩLMW OH-PAHs with urinary 8-OHdG or 8-iso-PGF2α, as well as an inverse dose-response relationship between urinary 8-OHdG and FVC, were observed (all P for trend < 0.05). Mediation analysis indicated that urinary 8-OHdG mediated 14.22% of the association between ƩHMW OH-PAH and FVC. Conclusion Higher levels of oxidative DNA damage might be involved in the decreased levels of FVC caused by high-molecular-weight PAH exposure.http://link.springer.com/article/10.1186/s12940-020-00621-xPolycyclic aromatic hydrocarbonsOxidative damageLung functionMediation effect
spellingShingle Limin Cao
Yun Zhou
Aijun Tan
Tingming Shi
Chunmei Zhu
Lili Xiao
Zhuang Zhang
Shijie Yang
Ge Mu
Xing Wang
Dongming Wang
Jixuan Ma
Weihong Chen
Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function
Environmental Health
Polycyclic aromatic hydrocarbons
Oxidative damage
Lung function
Mediation effect
title Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function
title_full Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function
title_fullStr Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function
title_full_unstemmed Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function
title_short Oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function
title_sort oxidative damage mediates the association between polycyclic aromatic hydrocarbon exposure and lung function
topic Polycyclic aromatic hydrocarbons
Oxidative damage
Lung function
Mediation effect
url http://link.springer.com/article/10.1186/s12940-020-00621-x
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