Role of concanavalin A lectin in recognition of pterygium remnant after surgical excision: Preliminary results of a prospective study
<b>Background: </b> Pterygium is one of the most common conjunctival diseases among ophthalmic pathologies. The frequency of recurrences is high, either after surgical treatment or after treatment combined with mitomycin C or beta-radiation therapy. <b> Aims: </b> The purpose...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2007-01-01
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| Series: | Indian Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.in/article.asp?issn=0301-4738;year=2007;volume=55;issue=5;spage=349;epage=353;aulast=Diaz-Gonzalez |
| _version_ | 1811323522392260608 |
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| author | Diaz-Gonzalez Juan Mayoral-Chavez Miguel Bohorquez Paulina de la Torre del Pilar Gabriel Hernandez-Cruz Pedro Martinez-Cruz Ruth Perez-Campos Eduardo |
| author_facet | Diaz-Gonzalez Juan Mayoral-Chavez Miguel Bohorquez Paulina de la Torre del Pilar Gabriel Hernandez-Cruz Pedro Martinez-Cruz Ruth Perez-Campos Eduardo |
| author_sort | Diaz-Gonzalez Juan |
| collection | DOAJ |
| description | <b>Background: </b> Pterygium is one of the most common conjunctival diseases among ophthalmic pathologies. The frequency of recurrences is high, either after surgical treatment or after treatment combined with mitomycin C or beta-radiation therapy. <b> Aims: </b> The purpose of this study was to determine whether concanavalin A (ConA) lectin bound to the pterygial surface can be used to detect recurrence or remnants of pterygium after surgical excision. <b> Materials and Methods: </b> This was a prospective study on 20 patients with pterygium, divided in five stages, pre-surgery, early post-surgery (24h), late post-surgery (seven days), very late post-surgery (four weeks) and two months after the procedure. A drop of fluorescein-marked Con A (35 µg/mL)<b> </b> was instilled in the lower conjunctival eyelid sac and the eye was exposed to the light of a Wood′s lamp for an average of five seconds. <b> Results: </b> Out of the 20 patients, eight patients were found to have fluorescent stretch marks over the scar corresponding to residual pterygial tissue at four weeks; two months after the procedure of re-surgery we observed no fluorescent remnants. All residual pterygia were confirmed through histochemistry studies. <b> Conclusion: </b> It was possible to detect remnants of pterygium in postoperative patients and recurrences in early pre-clinical stages through the visualization of fluorescent ConA bound to the pterygial surface. |
| first_indexed | 2024-04-13T13:56:39Z |
| format | Article |
| id | doaj.art-583529f63dff4303a65d8830cf467b35 |
| institution | Directory Open Access Journal |
| issn | 0301-4738 |
| language | English |
| last_indexed | 2024-04-13T13:56:39Z |
| publishDate | 2007-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Ophthalmology |
| spelling | doaj.art-583529f63dff4303a65d8830cf467b352022-12-22T02:44:10ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47382007-01-01555349353Role of concanavalin A lectin in recognition of pterygium remnant after surgical excision: Preliminary results of a prospective studyDiaz-Gonzalez JuanMayoral-Chavez MiguelBohorquez Paulinade la Torre del Pilar GabrielHernandez-Cruz PedroMartinez-Cruz RuthPerez-Campos Eduardo<b>Background: </b> Pterygium is one of the most common conjunctival diseases among ophthalmic pathologies. The frequency of recurrences is high, either after surgical treatment or after treatment combined with mitomycin C or beta-radiation therapy. <b> Aims: </b> The purpose of this study was to determine whether concanavalin A (ConA) lectin bound to the pterygial surface can be used to detect recurrence or remnants of pterygium after surgical excision. <b> Materials and Methods: </b> This was a prospective study on 20 patients with pterygium, divided in five stages, pre-surgery, early post-surgery (24h), late post-surgery (seven days), very late post-surgery (four weeks) and two months after the procedure. A drop of fluorescein-marked Con A (35 µg/mL)<b> </b> was instilled in the lower conjunctival eyelid sac and the eye was exposed to the light of a Wood′s lamp for an average of five seconds. <b> Results: </b> Out of the 20 patients, eight patients were found to have fluorescent stretch marks over the scar corresponding to residual pterygial tissue at four weeks; two months after the procedure of re-surgery we observed no fluorescent remnants. All residual pterygia were confirmed through histochemistry studies. <b> Conclusion: </b> It was possible to detect remnants of pterygium in postoperative patients and recurrences in early pre-clinical stages through the visualization of fluorescent ConA bound to the pterygial surface.http://www.ijo.in/article.asp?issn=0301-4738;year=2007;volume=55;issue=5;spage=349;epage=353;aulast=Diaz-GonzalezConcanavalin A lectinpterygium |
| spellingShingle | Diaz-Gonzalez Juan Mayoral-Chavez Miguel Bohorquez Paulina de la Torre del Pilar Gabriel Hernandez-Cruz Pedro Martinez-Cruz Ruth Perez-Campos Eduardo Role of concanavalin A lectin in recognition of pterygium remnant after surgical excision: Preliminary results of a prospective study Indian Journal of Ophthalmology Concanavalin A lectin pterygium |
| title | Role of concanavalin A lectin in recognition of pterygium remnant after surgical excision: Preliminary results of a prospective study |
| title_full | Role of concanavalin A lectin in recognition of pterygium remnant after surgical excision: Preliminary results of a prospective study |
| title_fullStr | Role of concanavalin A lectin in recognition of pterygium remnant after surgical excision: Preliminary results of a prospective study |
| title_full_unstemmed | Role of concanavalin A lectin in recognition of pterygium remnant after surgical excision: Preliminary results of a prospective study |
| title_short | Role of concanavalin A lectin in recognition of pterygium remnant after surgical excision: Preliminary results of a prospective study |
| title_sort | role of concanavalin a lectin in recognition of pterygium remnant after surgical excision preliminary results of a prospective study |
| topic | Concanavalin A lectin pterygium |
| url | http://www.ijo.in/article.asp?issn=0301-4738;year=2007;volume=55;issue=5;spage=349;epage=353;aulast=Diaz-Gonzalez |
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