Correlation of Fasting Serum Magnesium with Glycaemic and Nephropathy Status in Type 2 Diabetes Mellitus
Introduction: The estimated prevalence of Hypomagnesemia in Type 2 Diabetes Mellitus (T2DM) ranges between 14% to 48% in various studies. Hypomagnesemia has been found to be associated with increased insulin resistance in patients of T2DM. Aim: The aim was to estimate fasting serum magnesium levels...
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JCDR Research and Publications Private Limited
2020-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/13652/43632_CE[Ra1]_F(SL)_PF1(ShG_KM)_PN(SL).pdf |
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| author | Aditya Dhanawat Lalatendu Mohanty Pravakar Khatua Sudhansu Sekhar Panda Guncha Maheshwari |
| author_facet | Aditya Dhanawat Lalatendu Mohanty Pravakar Khatua Sudhansu Sekhar Panda Guncha Maheshwari |
| author_sort | Aditya Dhanawat |
| collection | DOAJ |
| description | Introduction: The estimated prevalence of Hypomagnesemia in Type 2 Diabetes Mellitus (T2DM) ranges between 14% to 48% in various studies. Hypomagnesemia has been found to be associated with increased insulin resistance in patients of T2DM.
Aim: The aim was to estimate fasting serum magnesium levels in the patients of T2DM and to correlate serum magnesium with glycaemic status and nephropathy status.
Materials and Methods: It was a cross-sectional study conducted at KIMS, Bhubaneswar between October 2017 to September 2019 which included a total of 187 T2DM patients. The glycaemic status was assessed by HbA1c and subdivided into good (HbA1c <7%), intermediate (HbA1c 7-9%) and poor control (HbA1c >9%). The nephropathy status was assessed by urine Albumin-Creatinine Ratio (ACR) and subdivided into macroalbuminuria (Urine ACR >300 mg/g), microalbuminuria (Urine ACR 30-299 mg/g) and non-nephropathy (Urine ACR <30 mg/g) groups. Student t-test and One-way ANOVA test were used to find the significance of mean pattern of serum magnesium in different groups and Pearson correlation coefficient test was used to correlate serum magnesium with glycaemic and nephropathy status.
Results: Out of 187 patients, 49 (26.2%) patients were found to have hypomagnesemia. In the poor glycaemic status group, 30% of patients had hypomagnesemia as compared to 26% in the intermediate and 19% in the good glycaemic status group. In the macroalbuminuria group, 41.3% patients had hypomagnesemia as compared to 17.6% in the microalbuminuria group and 4.5% in the non-nephropathy group.
Conclusion: There was a weak negative correlation (r=-0.04) between serum magnesium and glycaemic status which was not statistically significant (p=0.62). There was a negative correlation (r=-0.17) between serum magnesium and nephropathy status which was found to be statistically significant (p=0.02). |
| first_indexed | 2024-12-22T00:35:04Z |
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| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-22T00:35:04Z |
| publishDate | 2020-04-01 |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-58355f32e1b844b18986559e08d0fb2a2022-12-21T18:44:49ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2020-04-01144OC21OC2510.7860/JCDR/2020/43632.13652Correlation of Fasting Serum Magnesium with Glycaemic and Nephropathy Status in Type 2 Diabetes MellitusAditya Dhanawat0Lalatendu Mohanty1Pravakar Khatua2Sudhansu Sekhar Panda3Guncha Maheshwari4PG Resident, Department of Internal Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.Professor, Department of Internal Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.Consultant, Department of Internal Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.Professor and Head, Department of Internal Medicine, Kalinga Institute of Medical Sciences, Bhubaneswar, Odisha, India.PG Resident, Department of Radiation Oncology, Sardar Patel Medical College, Bikaner, Rajasthan, India.Introduction: The estimated prevalence of Hypomagnesemia in Type 2 Diabetes Mellitus (T2DM) ranges between 14% to 48% in various studies. Hypomagnesemia has been found to be associated with increased insulin resistance in patients of T2DM. Aim: The aim was to estimate fasting serum magnesium levels in the patients of T2DM and to correlate serum magnesium with glycaemic status and nephropathy status. Materials and Methods: It was a cross-sectional study conducted at KIMS, Bhubaneswar between October 2017 to September 2019 which included a total of 187 T2DM patients. The glycaemic status was assessed by HbA1c and subdivided into good (HbA1c <7%), intermediate (HbA1c 7-9%) and poor control (HbA1c >9%). The nephropathy status was assessed by urine Albumin-Creatinine Ratio (ACR) and subdivided into macroalbuminuria (Urine ACR >300 mg/g), microalbuminuria (Urine ACR 30-299 mg/g) and non-nephropathy (Urine ACR <30 mg/g) groups. Student t-test and One-way ANOVA test were used to find the significance of mean pattern of serum magnesium in different groups and Pearson correlation coefficient test was used to correlate serum magnesium with glycaemic and nephropathy status. Results: Out of 187 patients, 49 (26.2%) patients were found to have hypomagnesemia. In the poor glycaemic status group, 30% of patients had hypomagnesemia as compared to 26% in the intermediate and 19% in the good glycaemic status group. In the macroalbuminuria group, 41.3% patients had hypomagnesemia as compared to 17.6% in the microalbuminuria group and 4.5% in the non-nephropathy group. Conclusion: There was a weak negative correlation (r=-0.04) between serum magnesium and glycaemic status which was not statistically significant (p=0.62). There was a negative correlation (r=-0.17) between serum magnesium and nephropathy status which was found to be statistically significant (p=0.02).https://jcdr.net/articles/PDF/13652/43632_CE[Ra1]_F(SL)_PF1(ShG_KM)_PN(SL).pdfdiabetic nephropathyhypomagnesemiaindiainsulin resistancemicroalbuminuria |
| spellingShingle | Aditya Dhanawat Lalatendu Mohanty Pravakar Khatua Sudhansu Sekhar Panda Guncha Maheshwari Correlation of Fasting Serum Magnesium with Glycaemic and Nephropathy Status in Type 2 Diabetes Mellitus Journal of Clinical and Diagnostic Research diabetic nephropathy hypomagnesemia india insulin resistance microalbuminuria |
| title | Correlation of Fasting Serum Magnesium with Glycaemic and Nephropathy Status in Type 2 Diabetes Mellitus |
| title_full | Correlation of Fasting Serum Magnesium with Glycaemic and Nephropathy Status in Type 2 Diabetes Mellitus |
| title_fullStr | Correlation of Fasting Serum Magnesium with Glycaemic and Nephropathy Status in Type 2 Diabetes Mellitus |
| title_full_unstemmed | Correlation of Fasting Serum Magnesium with Glycaemic and Nephropathy Status in Type 2 Diabetes Mellitus |
| title_short | Correlation of Fasting Serum Magnesium with Glycaemic and Nephropathy Status in Type 2 Diabetes Mellitus |
| title_sort | correlation of fasting serum magnesium with glycaemic and nephropathy status in type 2 diabetes mellitus |
| topic | diabetic nephropathy hypomagnesemia india insulin resistance microalbuminuria |
| url | https://jcdr.net/articles/PDF/13652/43632_CE[Ra1]_F(SL)_PF1(ShG_KM)_PN(SL).pdf |
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