Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke
Purpose Previous studies have found that uric acid (UA) plays a neuroprotective role in ischemic stroke patients. However, the relationship between serum UA of acute ischemic stroke (AIS) and large vessel occlusion (LVO) strokes is unclear. Methods In this retrospective study, 1318 AIS patients were...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-02-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | http://dx.doi.org/10.1080/10641963.2021.2013490 |
| _version_ | 1797681095785840640 |
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| author | Jin Wei Ruihua Yin Xuening Li Xudong Pan Aijun Ma |
| author_facet | Jin Wei Ruihua Yin Xuening Li Xudong Pan Aijun Ma |
| author_sort | Jin Wei |
| collection | DOAJ |
| description | Purpose Previous studies have found that uric acid (UA) plays a neuroprotective role in ischemic stroke patients. However, the relationship between serum UA of acute ischemic stroke (AIS) and large vessel occlusion (LVO) strokes is unclear. Methods In this retrospective study, 1318 AIS patients were enrolled. All patients underwent imaging examinations to assess the intracranial and carotid vessels. Multivariate logistic regression analysis was conducted to evaluate the relationship between UA levels and the prevalence of LVO. Results The 1318 enrolled AIS patients were comprised of 287 LVO and 1031 non-LVO patients. UA levels in males were higher than females (321.04 ± 91.28 vs. 274.43 ± 82.11, p < .001). The association between serum UA levels and LVO was modified by sex (p = .007). When serum UA levels were continuous, after adjusting for related risk factors, higher serum UA levels were still associated with a lower prevalence of LVO in males (odds ratio (OR) 0.997, 95% confidence interval (CI) 0.994–0.999), but not in female subjects (OR 0.998, 95% CI 0.995–1.001). When serum UA levels were divided into tertiles, higher UA levels had a lower risk of LVO than the moderate (p = .006) and lower tertiles of UA levels (p = .010) in males, but not in females (p = .402 and p = .206 for moderate and low tertiles, respectively). Conclusions AIS patients with higher serum UA levels tend to be associated with a lower risk of LVO in males, but not in females. |
| first_indexed | 2024-03-11T23:39:54Z |
| format | Article |
| id | doaj.art-5838bc5d87a346dd9604a5cebbd8cff0 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:39:54Z |
| publishDate | 2022-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-5838bc5d87a346dd9604a5cebbd8cff02023-09-19T16:04:07ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062022-02-0144215415810.1080/10641963.2021.20134902013490Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic strokeJin Wei0Ruihua Yin1Xuening Li2Xudong Pan3Aijun Ma4The Affiliated Hospital of Qingdao UniversityThe Affiliated Hospital of Qingdao UniversityThe Affiliated Hospital of Qingdao UniversityThe Affiliated Hospital of Qingdao UniversityThe Affiliated Hospital of Qingdao UniversityPurpose Previous studies have found that uric acid (UA) plays a neuroprotective role in ischemic stroke patients. However, the relationship between serum UA of acute ischemic stroke (AIS) and large vessel occlusion (LVO) strokes is unclear. Methods In this retrospective study, 1318 AIS patients were enrolled. All patients underwent imaging examinations to assess the intracranial and carotid vessels. Multivariate logistic regression analysis was conducted to evaluate the relationship between UA levels and the prevalence of LVO. Results The 1318 enrolled AIS patients were comprised of 287 LVO and 1031 non-LVO patients. UA levels in males were higher than females (321.04 ± 91.28 vs. 274.43 ± 82.11, p < .001). The association between serum UA levels and LVO was modified by sex (p = .007). When serum UA levels were continuous, after adjusting for related risk factors, higher serum UA levels were still associated with a lower prevalence of LVO in males (odds ratio (OR) 0.997, 95% confidence interval (CI) 0.994–0.999), but not in female subjects (OR 0.998, 95% CI 0.995–1.001). When serum UA levels were divided into tertiles, higher UA levels had a lower risk of LVO than the moderate (p = .006) and lower tertiles of UA levels (p = .010) in males, but not in females (p = .402 and p = .206 for moderate and low tertiles, respectively). Conclusions AIS patients with higher serum UA levels tend to be associated with a lower risk of LVO in males, but not in females.http://dx.doi.org/10.1080/10641963.2021.2013490uric acidlarge vessel occlusionacute ischemic strokeoxidative stresssex-difference |
| spellingShingle | Jin Wei Ruihua Yin Xuening Li Xudong Pan Aijun Ma Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke Clinical and Experimental Hypertension uric acid large vessel occlusion acute ischemic stroke oxidative stress sex-difference |
| title | Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke |
| title_full | Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke |
| title_fullStr | Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke |
| title_full_unstemmed | Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke |
| title_short | Sex-specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke |
| title_sort | sex specific relationship between serum uric acid levels and the prevalence of large vessel occlusion in acute ischemic stroke |
| topic | uric acid large vessel occlusion acute ischemic stroke oxidative stress sex-difference |
| url | http://dx.doi.org/10.1080/10641963.2021.2013490 |
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