Synthesis of zinc oxide based etoricoxib and montelukast nanoformulations and their evaluation through analgesic, anti-inflammatory, anti-pyretic and acute toxicity activities
The current study described the synthesis of novel low dose PVA capped Etoricoxib (ET) and montelukast (MT) conjugated Zinc Oxide (ZnO) nanomaterials (NMs) as potential anti-inflammatory, analgesic and antipyretic agents. A facile coprecipitation protocol was used for synthesis of NMs by combination...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Journal of King Saud University: Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1018364722001197 |
| _version_ | 1811256152553422848 |
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| author | Sulaiman Sulaiman Shabir Ahmad Syeda Sohaila Naz Sara Qaisar Sayyar Muhammad Riaz Ullah Mohammad Khalid Al-Sadoon Aneela Gulnaz |
| author_facet | Sulaiman Sulaiman Shabir Ahmad Syeda Sohaila Naz Sara Qaisar Sayyar Muhammad Riaz Ullah Mohammad Khalid Al-Sadoon Aneela Gulnaz |
| author_sort | Sulaiman Sulaiman |
| collection | DOAJ |
| description | The current study described the synthesis of novel low dose PVA capped Etoricoxib (ET) and montelukast (MT) conjugated Zinc Oxide (ZnO) nanomaterials (NMs) as potential anti-inflammatory, analgesic and antipyretic agents. A facile coprecipitation protocol was used for synthesis of NMs by combination of ET, MT and ZnO NP. The efficient synthesis of ET and MT conjugated ZnO NMs were confirmed through UV–visible, XRD, FTIR and DLS analysis. Data of in vivo anti-inflammatory activity indicated that potency of ZnO NMs was found to be greater than drugs (ET and MT). Analgesic potency of NMs was much higher than that of drugs (ET and MT). The in vivo antipyretic activity indicates that the results of NMs and drugs (ET and MT) are of similar effect but that of NMs are more potent based on per weight basis. A wide therapeutic window was shown by the acute toxicity study carried out via LD50 method. It is concluded that the novel low dose PVA capped ET and MT conjugated ZnO NMs were potential analgesic, antipyretic and anti-inflammatory agents. |
| first_indexed | 2024-04-12T17:36:37Z |
| format | Article |
| id | doaj.art-583b372a7f934ab59b0e744567c8eb9f |
| institution | Directory Open Access Journal |
| issn | 1018-3647 |
| language | English |
| last_indexed | 2024-04-12T17:36:37Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of King Saud University: Science |
| spelling | doaj.art-583b372a7f934ab59b0e744567c8eb9f2022-12-22T03:22:58ZengElsevierJournal of King Saud University: Science1018-36472022-06-01344101938Synthesis of zinc oxide based etoricoxib and montelukast nanoformulations and their evaluation through analgesic, anti-inflammatory, anti-pyretic and acute toxicity activitiesSulaiman Sulaiman0Shabir Ahmad1Syeda Sohaila Naz2Sara Qaisar3Sayyar Muhammad4Riaz Ullah5Mohammad Khalid Al-Sadoon6Aneela Gulnaz7Department of Chemistry, Islamia College University, Peshawar, KPK, Pakistan; Nanosciences and Technology Department, National Centre for Physics, Quaid-i-Azam University Campus, Islamabad 44000, PakistanDepartment of Chemistry, Islamia College University, Peshawar, KPK, PakistanNanosciences and Technology Department, National Centre for Physics, Quaid-i-Azam University Campus, Islamabad 44000, PakistanNanosciences and Technology Department, National Centre for Physics, Quaid-i-Azam University Campus, Islamabad 44000, PakistanDepartment of Chemistry, Islamia College University, Peshawar, KPK, PakistanDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; Corresponding author.Department of Zoology, College of Science, King Saud University, PO Box 2455, Riyadh 11451, Saudi ArabiaCollege of Pharmacy, Woosuk University, Wanju-gun 55338, Republic of KoreaThe current study described the synthesis of novel low dose PVA capped Etoricoxib (ET) and montelukast (MT) conjugated Zinc Oxide (ZnO) nanomaterials (NMs) as potential anti-inflammatory, analgesic and antipyretic agents. A facile coprecipitation protocol was used for synthesis of NMs by combination of ET, MT and ZnO NP. The efficient synthesis of ET and MT conjugated ZnO NMs were confirmed through UV–visible, XRD, FTIR and DLS analysis. Data of in vivo anti-inflammatory activity indicated that potency of ZnO NMs was found to be greater than drugs (ET and MT). Analgesic potency of NMs was much higher than that of drugs (ET and MT). The in vivo antipyretic activity indicates that the results of NMs and drugs (ET and MT) are of similar effect but that of NMs are more potent based on per weight basis. A wide therapeutic window was shown by the acute toxicity study carried out via LD50 method. It is concluded that the novel low dose PVA capped ET and MT conjugated ZnO NMs were potential analgesic, antipyretic and anti-inflammatory agents.http://www.sciencedirect.com/science/article/pii/S1018364722001197Zinc oxide nanoparticlesEtoricoxibMontelukastAnalgesic activityAnti-inflammatory activityAnti pyretic activity |
| spellingShingle | Sulaiman Sulaiman Shabir Ahmad Syeda Sohaila Naz Sara Qaisar Sayyar Muhammad Riaz Ullah Mohammad Khalid Al-Sadoon Aneela Gulnaz Synthesis of zinc oxide based etoricoxib and montelukast nanoformulations and their evaluation through analgesic, anti-inflammatory, anti-pyretic and acute toxicity activities Journal of King Saud University: Science Zinc oxide nanoparticles Etoricoxib Montelukast Analgesic activity Anti-inflammatory activity Anti pyretic activity |
| title | Synthesis of zinc oxide based etoricoxib and montelukast nanoformulations and their evaluation through analgesic, anti-inflammatory, anti-pyretic and acute toxicity activities |
| title_full | Synthesis of zinc oxide based etoricoxib and montelukast nanoformulations and their evaluation through analgesic, anti-inflammatory, anti-pyretic and acute toxicity activities |
| title_fullStr | Synthesis of zinc oxide based etoricoxib and montelukast nanoformulations and their evaluation through analgesic, anti-inflammatory, anti-pyretic and acute toxicity activities |
| title_full_unstemmed | Synthesis of zinc oxide based etoricoxib and montelukast nanoformulations and their evaluation through analgesic, anti-inflammatory, anti-pyretic and acute toxicity activities |
| title_short | Synthesis of zinc oxide based etoricoxib and montelukast nanoformulations and their evaluation through analgesic, anti-inflammatory, anti-pyretic and acute toxicity activities |
| title_sort | synthesis of zinc oxide based etoricoxib and montelukast nanoformulations and their evaluation through analgesic anti inflammatory anti pyretic and acute toxicity activities |
| topic | Zinc oxide nanoparticles Etoricoxib Montelukast Analgesic activity Anti-inflammatory activity Anti pyretic activity |
| url | http://www.sciencedirect.com/science/article/pii/S1018364722001197 |
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