Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis
Rheumatoid arthritis is a chronic, systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate. Several drugs have been used for the treatment of rheumatoid arthritis, but their use is limited by suboptimal bioavailability, serious adverse ef...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-11-01
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| Series: | Acta Pharmaceutica Sinica B |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211383523001703 |
| _version_ | 1797647884549619712 |
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| author | Yuyi Xu Ming Zhao Jinxue Cao Ting Fang Jian Zhang Yanli Zhen Fangling Wu Xiaohui Yu Yaming Liu Ji Li Dongkai Wang |
| author_facet | Yuyi Xu Ming Zhao Jinxue Cao Ting Fang Jian Zhang Yanli Zhen Fangling Wu Xiaohui Yu Yaming Liu Ji Li Dongkai Wang |
| author_sort | Yuyi Xu |
| collection | DOAJ |
| description | Rheumatoid arthritis is a chronic, systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate. Several drugs have been used for the treatment of rheumatoid arthritis, but their use is limited by suboptimal bioavailability, serious adverse effects, and nonnegligible first-pass effects. In contrast, transdermal drug delivery systems (TDDSs) can avoid these drawbacks and improve patient compliance, making them a promising option for the treatment of rheumatoid arthritis (RA). Of course, TDDSs also face unique challenges, as the physiological barrier of the skin makes drug delivery somewhat limited. To overcome this barrier and maximize drug delivery efficiency, TDDSs have evolved in terms of the principle of transdermal facilitation and transdermal facilitation technology, and different generations of TDDSs have been derived, which have significantly improved transdermal efficiency and even achieved individualized controlled drug delivery. In this review, we summarize the different generations of transdermal drug delivery systems, the corresponding transdermal strategies, and their applications in the treatment of RA. |
| first_indexed | 2024-03-11T15:24:11Z |
| format | Article |
| id | doaj.art-583d48ab31a74efe95ced5aa4efadf58 |
| institution | Directory Open Access Journal |
| issn | 2211-3835 |
| language | English |
| last_indexed | 2024-03-11T15:24:11Z |
| publishDate | 2023-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Acta Pharmaceutica Sinica B |
| spelling | doaj.art-583d48ab31a74efe95ced5aa4efadf582023-10-28T05:07:00ZengElsevierActa Pharmaceutica Sinica B2211-38352023-11-01131144174441Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritisYuyi Xu0Ming Zhao1Jinxue Cao2Ting Fang3Jian Zhang4Yanli Zhen5Fangling Wu6Xiaohui Yu7Yaming Liu8Ji Li9Dongkai Wang10Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaDepartment of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaCorresponding authors.; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaCorresponding authors.; Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, ChinaRheumatoid arthritis is a chronic, systemic autoimmune disease predominantly based on joint lesions with an extremely high disability and deformity rate. Several drugs have been used for the treatment of rheumatoid arthritis, but their use is limited by suboptimal bioavailability, serious adverse effects, and nonnegligible first-pass effects. In contrast, transdermal drug delivery systems (TDDSs) can avoid these drawbacks and improve patient compliance, making them a promising option for the treatment of rheumatoid arthritis (RA). Of course, TDDSs also face unique challenges, as the physiological barrier of the skin makes drug delivery somewhat limited. To overcome this barrier and maximize drug delivery efficiency, TDDSs have evolved in terms of the principle of transdermal facilitation and transdermal facilitation technology, and different generations of TDDSs have been derived, which have significantly improved transdermal efficiency and even achieved individualized controlled drug delivery. In this review, we summarize the different generations of transdermal drug delivery systems, the corresponding transdermal strategies, and their applications in the treatment of RA.http://www.sciencedirect.com/science/article/pii/S2211383523001703Rheumatoid arthritisTransdermal drug delivery systemsDifferent generationsEnhancement strategiesDrug therapyTransdermal delivery mechanism |
| spellingShingle | Yuyi Xu Ming Zhao Jinxue Cao Ting Fang Jian Zhang Yanli Zhen Fangling Wu Xiaohui Yu Yaming Liu Ji Li Dongkai Wang Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis Acta Pharmaceutica Sinica B Rheumatoid arthritis Transdermal drug delivery systems Different generations Enhancement strategies Drug therapy Transdermal delivery mechanism |
| title | Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis |
| title_full | Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis |
| title_fullStr | Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis |
| title_full_unstemmed | Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis |
| title_short | Applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis |
| title_sort | applications and recent advances in transdermal drug delivery systems for the treatment of rheumatoid arthritis |
| topic | Rheumatoid arthritis Transdermal drug delivery systems Different generations Enhancement strategies Drug therapy Transdermal delivery mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2211383523001703 |
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