Interpreting discordant indirect and multiple treatment comparison meta-analyses: an evaluation of direct acting antivirals for chronic hepatitis C infection
Eric Druyts,1 Kristian Thorlund,2,3 Samantha Humphreys,4 Michaela Lion,4 Curtis L Cooper,5 Edward J Mills1,31Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada; 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada; 3Stanford Pr...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2013-06-01
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| Series: | Clinical Epidemiology |
| Online Access: | http://www.dovepress.com/interpreting-discordant-indirect-and-multiple-treatment-comparison-met-a13409 |
| _version_ | 1818484360080261120 |
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| author | Druyts E Thorlund K Humphreys S Lion M Cooper CL Mills EJ |
| author_facet | Druyts E Thorlund K Humphreys S Lion M Cooper CL Mills EJ |
| author_sort | Druyts E |
| collection | DOAJ |
| description | Eric Druyts,1 Kristian Thorlund,2,3 Samantha Humphreys,4 Michaela Lion,4 Curtis L Cooper,5 Edward J Mills1,31Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada; 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada; 3Stanford Prevention Research Centre, Department of Medicine, Stanford University, Palo Alto, CA, USA; 4Merck Sharp and Dohme Ltd, UK; 5Division of Infectious Diseases, Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, CanadaAbstract: Indirect treatment comparison (ITC) and multiple treatment comparison (MTC) meta-analyses are increasingly being used to estimate the comparative effectiveness of interventions when head-to-head data do not exist. ITC meta-analyses can be conducted using simple methodology to compare two interventions. MTC meta-analyses can be conducted using more complex methodology, often employing Bayesian approaches, to compare multiple interventions. As the number of ITC and MTC meta-analyses increase, it is common to find multiple analyses evaluating the same interventions in similar therapeutic areas. Depending on the choice of the methodological approach, the conclusions about relative treatment efficacy may differ. Such situations create uncertainty for decision makers. An illustration of this is provided by four ITC and MTC meta-analyses assessing the efficacy of boceprevir and telaprevir for chronic hepatitis C virus infection. This paper examines why these evaluations provide discordant results by examining specific methodological issues that can strengthen or weaken inferences.Keywords: indirect treatment comparison, multiple treatment comparison, meta-analysis, hepatitis C virus |
| first_indexed | 2024-12-10T15:54:18Z |
| format | Article |
| id | doaj.art-583f2de2a39d4baaa8b359464ecc48fb |
| institution | Directory Open Access Journal |
| issn | 1179-1349 |
| language | English |
| last_indexed | 2024-12-10T15:54:18Z |
| publishDate | 2013-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical Epidemiology |
| spelling | doaj.art-583f2de2a39d4baaa8b359464ecc48fb2022-12-22T01:42:42ZengDove Medical PressClinical Epidemiology1179-13492013-06-012013Issue 1173183Interpreting discordant indirect and multiple treatment comparison meta-analyses: an evaluation of direct acting antivirals for chronic hepatitis C infectionDruyts EThorlund KHumphreys SLion MCooper CLMills EJEric Druyts,1 Kristian Thorlund,2,3 Samantha Humphreys,4 Michaela Lion,4 Curtis L Cooper,5 Edward J Mills1,31Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada; 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada; 3Stanford Prevention Research Centre, Department of Medicine, Stanford University, Palo Alto, CA, USA; 4Merck Sharp and Dohme Ltd, UK; 5Division of Infectious Diseases, Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, CanadaAbstract: Indirect treatment comparison (ITC) and multiple treatment comparison (MTC) meta-analyses are increasingly being used to estimate the comparative effectiveness of interventions when head-to-head data do not exist. ITC meta-analyses can be conducted using simple methodology to compare two interventions. MTC meta-analyses can be conducted using more complex methodology, often employing Bayesian approaches, to compare multiple interventions. As the number of ITC and MTC meta-analyses increase, it is common to find multiple analyses evaluating the same interventions in similar therapeutic areas. Depending on the choice of the methodological approach, the conclusions about relative treatment efficacy may differ. Such situations create uncertainty for decision makers. An illustration of this is provided by four ITC and MTC meta-analyses assessing the efficacy of boceprevir and telaprevir for chronic hepatitis C virus infection. This paper examines why these evaluations provide discordant results by examining specific methodological issues that can strengthen or weaken inferences.Keywords: indirect treatment comparison, multiple treatment comparison, meta-analysis, hepatitis C virushttp://www.dovepress.com/interpreting-discordant-indirect-and-multiple-treatment-comparison-met-a13409 |
| spellingShingle | Druyts E Thorlund K Humphreys S Lion M Cooper CL Mills EJ Interpreting discordant indirect and multiple treatment comparison meta-analyses: an evaluation of direct acting antivirals for chronic hepatitis C infection Clinical Epidemiology |
| title | Interpreting discordant indirect and multiple treatment comparison meta-analyses: an evaluation of direct acting antivirals for chronic hepatitis C infection |
| title_full | Interpreting discordant indirect and multiple treatment comparison meta-analyses: an evaluation of direct acting antivirals for chronic hepatitis C infection |
| title_fullStr | Interpreting discordant indirect and multiple treatment comparison meta-analyses: an evaluation of direct acting antivirals for chronic hepatitis C infection |
| title_full_unstemmed | Interpreting discordant indirect and multiple treatment comparison meta-analyses: an evaluation of direct acting antivirals for chronic hepatitis C infection |
| title_short | Interpreting discordant indirect and multiple treatment comparison meta-analyses: an evaluation of direct acting antivirals for chronic hepatitis C infection |
| title_sort | interpreting discordant indirect and multiple treatment comparison meta analyses an evaluation of direct acting antivirals for chronic hepatitis c infection |
| url | http://www.dovepress.com/interpreting-discordant-indirect-and-multiple-treatment-comparison-met-a13409 |
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