GDF9 His209GlnfsTer6/S428T and GDF9 Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargement

GDF9 His209GlnfsTer6/S428T and GDF9 Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargement

Abstract Background Antral follicles consist of an oocyte cumulus complex surrounding by somatic cells, including mural granulosa cells as the inner layer and theca cells as the outsider layer. The communications between oocytes and granulosa cells have been extensively explored in in vitro studies,...

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Bibliographic Details
Main Authors: Yuwei Duan, Bing Cai, Jing Guo, Chen Wang, Qingyun Mai, Yan Xu, Yang Zeng, Yue Shi, Boyan Wang, Chenhui Ding, Minghui Chen, Canquan Zhou, Yanwen Xu
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Cell Communication and Signaling
Subjects:
GDF9
Poor ovarian response
Follicular enlargement
Steroidogenesis
In vivo model
Online Access:https://doi.org/10.1186/s12964-024-01616-8

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