Role of Microbiota in Aetiopathogenesis of Colorectal Cancer
Colorectal Cancer (CRC) accounts for sizeable disease burden globally. The symbiotic association between gut inhabitants and the digestive tract contributes to gut homeostasis. Studies suggest that altered microbiota composition or dysbiosis can contribute to colorectal carcinogenesis. This review o...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2020-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/13169/42445_CE[Ra1]_F(KM)_PF1(AG_AaG_SHU)_PN(SL).pdf |
| _version_ | 1818386196337786880 |
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| author | Arpita Suri Sanjiv Kumar Bansal Prajwal Ammalli Busi Karunanand |
| author_facet | Arpita Suri Sanjiv Kumar Bansal Prajwal Ammalli Busi Karunanand |
| author_sort | Arpita Suri |
| collection | DOAJ |
| description | Colorectal Cancer (CRC) accounts for sizeable disease burden globally. The symbiotic association between gut inhabitants and the digestive tract contributes to gut homeostasis. Studies suggest that altered microbiota composition or dysbiosis can contribute to colorectal carcinogenesis. This review outlines the complex interplay between the microbiome, diet and CRC with a special emphasis on microbial metabolites, gut barrier function, specific bacterial species which influence the micro environment by various mechanisms like oxidative stress, DNA damage, immune modulation and inflammation. This would help in establishing novel diagnostic, prognostic markers and newer therapeutics for CRC. |
| first_indexed | 2024-12-14T03:50:12Z |
| format | Article |
| id | doaj.art-5840806ff67d4137802996e4aa1f958f |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-14T03:50:12Z |
| publishDate | 2020-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-5840806ff67d4137802996e4aa1f958f2022-12-21T23:18:15ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2020-03-01139BE01BE0510.7860/JCDR/2019/42445.13169Role of Microbiota in Aetiopathogenesis of Colorectal CancerArpita Suri0Sanjiv Kumar Bansal1Prajwal Ammalli2Busi Karunanand3Assistant Professor, Department of Biochemistry, SGT Medical College Hospital and Research Institute, Gurugram, Haryana, India.Professor, Department of Biochemistry, SGT Medical College Hospital and Research Institute, Gurugram, Haryana, India.Senior Resident, Department of Biochemistry, Institute of Liver and Biliary Sciences, New Delhi, India.Professor and Head, Department of Biochemistry, SGT Medical College Hospital and Research Institute, Gurugram, Haryana, India.Colorectal Cancer (CRC) accounts for sizeable disease burden globally. The symbiotic association between gut inhabitants and the digestive tract contributes to gut homeostasis. Studies suggest that altered microbiota composition or dysbiosis can contribute to colorectal carcinogenesis. This review outlines the complex interplay between the microbiome, diet and CRC with a special emphasis on microbial metabolites, gut barrier function, specific bacterial species which influence the micro environment by various mechanisms like oxidative stress, DNA damage, immune modulation and inflammation. This would help in establishing novel diagnostic, prognostic markers and newer therapeutics for CRC.https://jcdr.net/articles/PDF/13169/42445_CE[Ra1]_F(KM)_PF1(AG_AaG_SHU)_PN(SL).pdfbutyratedysbiosisgut microbiotamicrobiome |
| spellingShingle | Arpita Suri Sanjiv Kumar Bansal Prajwal Ammalli Busi Karunanand Role of Microbiota in Aetiopathogenesis of Colorectal Cancer Journal of Clinical and Diagnostic Research butyrate dysbiosis gut microbiota microbiome |
| title | Role of Microbiota in Aetiopathogenesis of Colorectal Cancer |
| title_full | Role of Microbiota in Aetiopathogenesis of Colorectal Cancer |
| title_fullStr | Role of Microbiota in Aetiopathogenesis of Colorectal Cancer |
| title_full_unstemmed | Role of Microbiota in Aetiopathogenesis of Colorectal Cancer |
| title_short | Role of Microbiota in Aetiopathogenesis of Colorectal Cancer |
| title_sort | role of microbiota in aetiopathogenesis of colorectal cancer |
| topic | butyrate dysbiosis gut microbiota microbiome |
| url | https://jcdr.net/articles/PDF/13169/42445_CE[Ra1]_F(KM)_PF1(AG_AaG_SHU)_PN(SL).pdf |
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