Structural control of self-assembled peptide nanostructures to develop peptide vesicles for photodynamic therapy of cancer
Vesicles such as liposomes, polymersomes, and exosomes have been widely used as drug delivery carriers; however, peptide vesicles (peptidesomes) despite their potential utility are far less well developed. Peptidesomes are distinctive because peptides play dual roles as a self-assembly building bloc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422001351 |
| _version_ | 1797990800375676928 |
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| author | Soo hyun Kwon Donghyun Lee Hyoseok Kim You-jin Jung Heebeom Koo Yong-beom Lim |
| author_facet | Soo hyun Kwon Donghyun Lee Hyoseok Kim You-jin Jung Heebeom Koo Yong-beom Lim |
| author_sort | Soo hyun Kwon |
| collection | DOAJ |
| description | Vesicles such as liposomes, polymersomes, and exosomes have been widely used as drug delivery carriers; however, peptide vesicles (peptidesomes) despite their potential utility are far less well developed. Peptidesomes are distinctive because peptides play dual roles as a self-assembly building block and a bioactive functional unit. In order for peptidesomes to become successful nanodrugs, the issues related to differences in nanostructural properties between in vitro and in vivo conditions should be addressed. Here, we delineate a multivariate approach to feedback control the structures of peptide building blocks, nanoparticle size, drug loading process, nanoparticle aggregation, cytotoxicity, cell targeting capability, endosome disruption function, protease resistance, and in vivo performance, which eventually enabled the successful development of a highly efficacious peptidesome for in vivo cancer therapy. This study lays the groundwork for the successful in vivo translation of peptide nanodrugs. |
| first_indexed | 2024-04-11T08:41:57Z |
| format | Article |
| id | doaj.art-5845f5e36a92489a9384ab82fa11f15a |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-11T08:41:57Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-5845f5e36a92489a9384ab82fa11f15a2022-12-22T04:34:11ZengElsevierMaterials Today Bio2590-00642022-12-0116100337Structural control of self-assembled peptide nanostructures to develop peptide vesicles for photodynamic therapy of cancerSoo hyun Kwon0Donghyun Lee1Hyoseok Kim2You-jin Jung3Heebeom Koo4Yong-beom Lim5Department of Materials Science and Engineering, Yonsei University, Seoul, 03722, Republic of KoreaDepartment of Medical Life Sciences and Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of KoreaDepartment of Materials Science and Engineering, Yonsei University, Seoul, 03722, Republic of KoreaDepartment of Materials Science and Engineering, Yonsei University, Seoul, 03722, Republic of KoreaDepartment of Medical Life Sciences and Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea; Corresponding author.Department of Materials Science and Engineering, Yonsei University, Seoul, 03722, Republic of Korea; Corresponding author.Vesicles such as liposomes, polymersomes, and exosomes have been widely used as drug delivery carriers; however, peptide vesicles (peptidesomes) despite their potential utility are far less well developed. Peptidesomes are distinctive because peptides play dual roles as a self-assembly building block and a bioactive functional unit. In order for peptidesomes to become successful nanodrugs, the issues related to differences in nanostructural properties between in vitro and in vivo conditions should be addressed. Here, we delineate a multivariate approach to feedback control the structures of peptide building blocks, nanoparticle size, drug loading process, nanoparticle aggregation, cytotoxicity, cell targeting capability, endosome disruption function, protease resistance, and in vivo performance, which eventually enabled the successful development of a highly efficacious peptidesome for in vivo cancer therapy. This study lays the groundwork for the successful in vivo translation of peptide nanodrugs.http://www.sciencedirect.com/science/article/pii/S2590006422001351Convergent correlationSelf-assemblyPeptidesMorphologyPhotodynamic therapyPeptidesome |
| spellingShingle | Soo hyun Kwon Donghyun Lee Hyoseok Kim You-jin Jung Heebeom Koo Yong-beom Lim Structural control of self-assembled peptide nanostructures to develop peptide vesicles for photodynamic therapy of cancer Materials Today Bio Convergent correlation Self-assembly Peptides Morphology Photodynamic therapy Peptidesome |
| title | Structural control of self-assembled peptide nanostructures to develop peptide vesicles for photodynamic therapy of cancer |
| title_full | Structural control of self-assembled peptide nanostructures to develop peptide vesicles for photodynamic therapy of cancer |
| title_fullStr | Structural control of self-assembled peptide nanostructures to develop peptide vesicles for photodynamic therapy of cancer |
| title_full_unstemmed | Structural control of self-assembled peptide nanostructures to develop peptide vesicles for photodynamic therapy of cancer |
| title_short | Structural control of self-assembled peptide nanostructures to develop peptide vesicles for photodynamic therapy of cancer |
| title_sort | structural control of self assembled peptide nanostructures to develop peptide vesicles for photodynamic therapy of cancer |
| topic | Convergent correlation Self-assembly Peptides Morphology Photodynamic therapy Peptidesome |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422001351 |
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