Branched chain amino acids metabolism in heart failure
As a terminal stage of various cardiovascular diseases, heart failure is of great concern due to its high mortality rate and limited treatment options. Researchers are currently focusing their efforts on investigating the metabolism of carbohydrates, fatty acids, and amino acids to enhance the progn...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Nutrition |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1279066/full |
| _version_ | 1797517344136757248 |
|---|---|
| author | Chenshan Gao Lei Hou Lei Hou |
| author_facet | Chenshan Gao Lei Hou Lei Hou |
| author_sort | Chenshan Gao |
| collection | DOAJ |
| description | As a terminal stage of various cardiovascular diseases, heart failure is of great concern due to its high mortality rate and limited treatment options. Researchers are currently focusing their efforts on investigating the metabolism of carbohydrates, fatty acids, and amino acids to enhance the prognosis of cardiovascular diseases. Simultaneously, branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, play significant roles in blood glucose regulation, protein synthesis, and insulin sensitivity. However, disrupted BCAAs metabolism has been associated with conditions such as hypertension, obesity, and atherosclerosis. This article explores intricate metabolic pathways, unveiling the connection between disrupted BCAAs metabolism and the progression of heart failure. Furthermore, the article discusses therapeutic strategies, assesses the impact of BCAAs on cardiac dysfunction, and examines the potential of modulating BCAAs metabolism as a treatment for heart failure. BCAAs and their metabolites are also considered as biomarkers for evaluating cardiac metabolic risk. In conclusion, this article elucidates the multifaceted roles of BCAAs in heart failure and cardiovascular health, providing guidance for future research and intervention measures. |
| first_indexed | 2024-03-10T07:14:23Z |
| format | Article |
| id | doaj.art-58464ad34c074811a5b8009d187beb5c |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-10T07:14:23Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-58464ad34c074811a5b8009d187beb5c2023-11-22T15:07:30ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-11-011010.3389/fnut.2023.12790661279066Branched chain amino acids metabolism in heart failureChenshan Gao0Lei Hou1Lei Hou2Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, Guangxi Medical University, Nanning, ChinaCollaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-Constructed by the Province and Ministry, Guangxi Medical University, Nanning, ChinaDepartment of Cardiology, Shanghai Songjiang District Central Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaAs a terminal stage of various cardiovascular diseases, heart failure is of great concern due to its high mortality rate and limited treatment options. Researchers are currently focusing their efforts on investigating the metabolism of carbohydrates, fatty acids, and amino acids to enhance the prognosis of cardiovascular diseases. Simultaneously, branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, play significant roles in blood glucose regulation, protein synthesis, and insulin sensitivity. However, disrupted BCAAs metabolism has been associated with conditions such as hypertension, obesity, and atherosclerosis. This article explores intricate metabolic pathways, unveiling the connection between disrupted BCAAs metabolism and the progression of heart failure. Furthermore, the article discusses therapeutic strategies, assesses the impact of BCAAs on cardiac dysfunction, and examines the potential of modulating BCAAs metabolism as a treatment for heart failure. BCAAs and their metabolites are also considered as biomarkers for evaluating cardiac metabolic risk. In conclusion, this article elucidates the multifaceted roles of BCAAs in heart failure and cardiovascular health, providing guidance for future research and intervention measures.https://www.frontiersin.org/articles/10.3389/fnut.2023.1279066/fullbranched-chain amino acidsheart failuremetabolic dysregulationHFrEF – heart failure with reduced ejection fractionHFpEF – heart failure with preserved ejection fraction |
| spellingShingle | Chenshan Gao Lei Hou Lei Hou Branched chain amino acids metabolism in heart failure Frontiers in Nutrition branched-chain amino acids heart failure metabolic dysregulation HFrEF – heart failure with reduced ejection fraction HFpEF – heart failure with preserved ejection fraction |
| title | Branched chain amino acids metabolism in heart failure |
| title_full | Branched chain amino acids metabolism in heart failure |
| title_fullStr | Branched chain amino acids metabolism in heart failure |
| title_full_unstemmed | Branched chain amino acids metabolism in heart failure |
| title_short | Branched chain amino acids metabolism in heart failure |
| title_sort | branched chain amino acids metabolism in heart failure |
| topic | branched-chain amino acids heart failure metabolic dysregulation HFrEF – heart failure with reduced ejection fraction HFpEF – heart failure with preserved ejection fraction |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1279066/full |
| work_keys_str_mv | AT chenshangao branchedchainaminoacidsmetabolisminheartfailure AT leihou branchedchainaminoacidsmetabolisminheartfailure AT leihou branchedchainaminoacidsmetabolisminheartfailure |