Characteristics of beta parapapillary atrophy in primary angle-closure suspect
Objective To investigate the characteristics of beta parapapillary atrophy (β-PPA) in patients with primary angle-closure suspect (PACS).Methods and analysis In total, 215 and 259 eyes with PACS and non-PACS (NPACS), respectively, were enrolled in this observational, cross-sectional study. Stereosco...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-04-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/9/1/e001529.full |
| _version_ | 1797205904307781632 |
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| author | Qing Zhang Ye Zhang Xiaohua Pan Hui Feng Shuning Li Zhi Li Meijuan Zhang Caixia Li Fei Xiang Qianqian Ji |
| author_facet | Qing Zhang Ye Zhang Xiaohua Pan Hui Feng Shuning Li Zhi Li Meijuan Zhang Caixia Li Fei Xiang Qianqian Ji |
| author_sort | Qing Zhang |
| collection | DOAJ |
| description | Objective To investigate the characteristics of beta parapapillary atrophy (β-PPA) in patients with primary angle-closure suspect (PACS).Methods and analysis In total, 215 and 259 eyes with PACS and non-PACS (NPACS), respectively, were enrolled in this observational, cross-sectional study. Stereoscopic fundus and optical coherence tomography images were used to characterise β-PPA; the former was also used to measure the major β-PPA parameters. Univariate and multiple logistic regression analyses were used to identify the factors correlated with the presence of β-PPA and with β-PPA parameters.Results The β-PPA occurrence rates were 48.80% and 44.40% in the PACS and NPACS groups, respectively, with no significant difference between groups. Compared with that in the NPACS group, the β-PPA area was significantly larger (p=0.005) in the PACS group, but the angular extent and maximum radial length did not differ between groups (p=0.110 and 0.657, respectively) after adjusting for age and axial length. The presence of β-PPA was associated with older age (OR 1.057, 95% CI 1.028 to 1.088, p<0.001) and larger disc area (OR 1.716, 95% CI 1.170 to 2.517, p=0.006). A larger β-PPA area was associated with older age (p=0.014), greater vertical cup-to-disc ratio (p=0.028), larger disc area (p<0.001) and PACS diagnosis (p=0.035).Conclusion 48.80% of participants with PACS had β-PPA, which is slightly larger than NPACS. The area of β-PPA was larger in PACS, while the angular extent and maximum radial length did not differ between groups. |
| first_indexed | 2024-04-24T08:58:32Z |
| format | Article |
| id | doaj.art-58466ff7bb04425c8127abdc179890d2 |
| institution | Directory Open Access Journal |
| issn | 2397-3269 |
| language | English |
| last_indexed | 2024-04-24T08:58:32Z |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj.art-58466ff7bb04425c8127abdc179890d22024-04-16T05:00:08ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692024-04-019110.1136/bmjophth-2023-001529Characteristics of beta parapapillary atrophy in primary angle-closure suspectQing Zhang0Ye Zhang1Xiaohua Pan2Hui Feng3Shuning Li4Zhi Li5Meijuan Zhang6Caixia Li7Fei Xiang8Qianqian Ji9Qilu hospital of Shandong University, Obstetrics and Gynecology, Jinan, Shandong province, ChinaDepartment of Rehabilitation Medicine, Shanghai Sixth People`s Hospital, Shanghai, ChinaBeijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, Beijing, ChinaAff1 grid.64924.3d0000000417605735Cancer Center, The First HospitalJilin University 130061 ChangchunJilin ChinaBeijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Science Key Lab, Capital Medical University, Beijing, ChinaDepartment of Critical Care Medicine, Cheng Du Shang Jin Nan Fu Hospital, West China Hospital of Sichuan University, Chengdu, Sichuan, China1 Department of Neurology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, ChinaDepartment of Obstetrics and Gynecology, Shanghai Tenth People`s Hospital, School of Medicine, Tongji University, Shanghai, People`s Republic of ChinaBeijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaBeijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University, Beijing, ChinaObjective To investigate the characteristics of beta parapapillary atrophy (β-PPA) in patients with primary angle-closure suspect (PACS).Methods and analysis In total, 215 and 259 eyes with PACS and non-PACS (NPACS), respectively, were enrolled in this observational, cross-sectional study. Stereoscopic fundus and optical coherence tomography images were used to characterise β-PPA; the former was also used to measure the major β-PPA parameters. Univariate and multiple logistic regression analyses were used to identify the factors correlated with the presence of β-PPA and with β-PPA parameters.Results The β-PPA occurrence rates were 48.80% and 44.40% in the PACS and NPACS groups, respectively, with no significant difference between groups. Compared with that in the NPACS group, the β-PPA area was significantly larger (p=0.005) in the PACS group, but the angular extent and maximum radial length did not differ between groups (p=0.110 and 0.657, respectively) after adjusting for age and axial length. The presence of β-PPA was associated with older age (OR 1.057, 95% CI 1.028 to 1.088, p<0.001) and larger disc area (OR 1.716, 95% CI 1.170 to 2.517, p=0.006). A larger β-PPA area was associated with older age (p=0.014), greater vertical cup-to-disc ratio (p=0.028), larger disc area (p<0.001) and PACS diagnosis (p=0.035).Conclusion 48.80% of participants with PACS had β-PPA, which is slightly larger than NPACS. The area of β-PPA was larger in PACS, while the angular extent and maximum radial length did not differ between groups.https://bmjophth.bmj.com/content/9/1/e001529.full |
| spellingShingle | Qing Zhang Ye Zhang Xiaohua Pan Hui Feng Shuning Li Zhi Li Meijuan Zhang Caixia Li Fei Xiang Qianqian Ji Characteristics of beta parapapillary atrophy in primary angle-closure suspect BMJ Open Ophthalmology |
| title | Characteristics of beta parapapillary atrophy in primary angle-closure suspect |
| title_full | Characteristics of beta parapapillary atrophy in primary angle-closure suspect |
| title_fullStr | Characteristics of beta parapapillary atrophy in primary angle-closure suspect |
| title_full_unstemmed | Characteristics of beta parapapillary atrophy in primary angle-closure suspect |
| title_short | Characteristics of beta parapapillary atrophy in primary angle-closure suspect |
| title_sort | characteristics of beta parapapillary atrophy in primary angle closure suspect |
| url | https://bmjophth.bmj.com/content/9/1/e001529.full |
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