Endometrial Cancer Arising in Adenomyosis (EC-AIA): A Systematic Review
Endometrial cancer arising in adenomyosis (EC-AIA) is a rare uterine disease characterized by the malignant transformation of the ectopic endometrium within the adenomyotic foci. Clinicopathological and survival data are mostly limited to case reports and a few cohort studies. We aimed to assess the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/4/1142 |
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| author | Antonio Raffone Diego Raimondo Manuela Maletta Antonio Travaglino Federica Renzulli Daniele Neola Umberto De Laurentiis Francesco De Laurentiis Mohamed Mabrouk Manuel Maria Ianieri Renato Seracchioli Paolo Casadio Antonio Mollo |
| author_facet | Antonio Raffone Diego Raimondo Manuela Maletta Antonio Travaglino Federica Renzulli Daniele Neola Umberto De Laurentiis Francesco De Laurentiis Mohamed Mabrouk Manuel Maria Ianieri Renato Seracchioli Paolo Casadio Antonio Mollo |
| author_sort | Antonio Raffone |
| collection | DOAJ |
| description | Endometrial cancer arising in adenomyosis (EC-AIA) is a rare uterine disease characterized by the malignant transformation of the ectopic endometrium within the adenomyotic foci. Clinicopathological and survival data are mostly limited to case reports and a few cohort studies. We aimed to assess the clinicopathological features and survival outcomes of women with EC-AIA through a systematic review of the literature. Six electronic databases were searched, from 2002 to 2022, for all peer-reviewed studies that reported EC-AIA cases. Thirty-seven EC-AIA patients from 27 case reports and four case series were included in our study. In our analysis, EC-AIA appeared as a rare disease that mainly occurs in menopausal women, shares symptoms with endometrial cancer, and is challenging to diagnose preoperatively. Differently from EC, it shows a higher prevalence of the non-endometrioid histotype, advanced FIGO stages, and p53-signature, which might be responsible for its worse prognosis. Future studies are necessary, to confirm our findings and further investigate this rare condition. |
| first_indexed | 2024-03-11T09:02:57Z |
| format | Article |
| id | doaj.art-5846701c8bf74b2596179b4c4383b260 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T09:02:57Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-5846701c8bf74b2596179b4c4383b2602023-11-16T19:36:46ZengMDPI AGCancers2072-66942023-02-01154114210.3390/cancers15041142Endometrial Cancer Arising in Adenomyosis (EC-AIA): A Systematic ReviewAntonio Raffone0Diego Raimondo1Manuela Maletta2Antonio Travaglino3Federica Renzulli4Daniele Neola5Umberto De Laurentiis6Francesco De Laurentiis7Mohamed Mabrouk8Manuel Maria Ianieri9Renato Seracchioli10Paolo Casadio11Antonio Mollo12Division of Gynaecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDivision of Gynaecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDivision of Gynaecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyPathology Unit, Department of Woman and Child’s Health and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, ItalyDivision of Gynaecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyGynecology and Obstetrics Unit, Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, Naples, ItalyDivision of Gynaecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyObstetrics and Gynecology Unit, Salerno ASL, “Luigi Curto” Hospital, Polla, Salerno, ItalyDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Cambridge, Cambridge, UKDivision of Gynecologic Oncology, Department of Women’s and Children’s Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, ItalyDivision of Gynaecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyDivision of Gynaecology and Human Reproduction Physiopathology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, ItalyGynecology and Obstetrics Unit, Department of Medicine, Surgery and Dentistry “Schola Medica Salernitana”, University of Salerno, 84081 Baronissi, ItalyEndometrial cancer arising in adenomyosis (EC-AIA) is a rare uterine disease characterized by the malignant transformation of the ectopic endometrium within the adenomyotic foci. Clinicopathological and survival data are mostly limited to case reports and a few cohort studies. We aimed to assess the clinicopathological features and survival outcomes of women with EC-AIA through a systematic review of the literature. Six electronic databases were searched, from 2002 to 2022, for all peer-reviewed studies that reported EC-AIA cases. Thirty-seven EC-AIA patients from 27 case reports and four case series were included in our study. In our analysis, EC-AIA appeared as a rare disease that mainly occurs in menopausal women, shares symptoms with endometrial cancer, and is challenging to diagnose preoperatively. Differently from EC, it shows a higher prevalence of the non-endometrioid histotype, advanced FIGO stages, and p53-signature, which might be responsible for its worse prognosis. Future studies are necessary, to confirm our findings and further investigate this rare condition.https://www.mdpi.com/2072-6694/15/4/1142endometr* malignancytumorstumourscarcinomaadenomyo* |
| spellingShingle | Antonio Raffone Diego Raimondo Manuela Maletta Antonio Travaglino Federica Renzulli Daniele Neola Umberto De Laurentiis Francesco De Laurentiis Mohamed Mabrouk Manuel Maria Ianieri Renato Seracchioli Paolo Casadio Antonio Mollo Endometrial Cancer Arising in Adenomyosis (EC-AIA): A Systematic Review Cancers endometr* malignancy tumors tumours carcinoma adenomyo* |
| title | Endometrial Cancer Arising in Adenomyosis (EC-AIA): A Systematic Review |
| title_full | Endometrial Cancer Arising in Adenomyosis (EC-AIA): A Systematic Review |
| title_fullStr | Endometrial Cancer Arising in Adenomyosis (EC-AIA): A Systematic Review |
| title_full_unstemmed | Endometrial Cancer Arising in Adenomyosis (EC-AIA): A Systematic Review |
| title_short | Endometrial Cancer Arising in Adenomyosis (EC-AIA): A Systematic Review |
| title_sort | endometrial cancer arising in adenomyosis ec aia a systematic review |
| topic | endometr* malignancy tumors tumours carcinoma adenomyo* |
| url | https://www.mdpi.com/2072-6694/15/4/1142 |
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