Prospective study of predictors for anxiety, depression, and somatization in a sample of 1807 cancer patients
Abstract In cancer patients, psychological distress, which encompasses anxiety, depression, and somatization, arises from the complex interplay of emotional and behavioral reactions to the diagnosis and treatment, significantly influencing their functionality and quality of life. The aim was to inve...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-024-53212-y |
| _version_ | 1827327895110942720 |
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| author | Veronica Velasco-Durantez Patricia Cruz-Castellanos Raquel Hernandez Adan Rodriguez-Gonzalez Ana Fernandez Montes Alejandro Gallego Aranzazu Manzano-Fernandez Elena Sorribes Marta Zafra Alberto Carmona-Bayonas Caterina Calderon Paula Jiménez-Fonseca |
| author_facet | Veronica Velasco-Durantez Patricia Cruz-Castellanos Raquel Hernandez Adan Rodriguez-Gonzalez Ana Fernandez Montes Alejandro Gallego Aranzazu Manzano-Fernandez Elena Sorribes Marta Zafra Alberto Carmona-Bayonas Caterina Calderon Paula Jiménez-Fonseca |
| author_sort | Veronica Velasco-Durantez |
| collection | DOAJ |
| description | Abstract In cancer patients, psychological distress, which encompasses anxiety, depression, and somatization, arises from the complex interplay of emotional and behavioral reactions to the diagnosis and treatment, significantly influencing their functionality and quality of life. The aim was to investigate factors associated with psychological distress in cancer patients. This prospective and multicenter study, conducted by the Spanish Society of Medical Oncology (SEOM), included two cohorts of patients with cancer (localized resected or advanced unresectable). They completed surveys assessing psychological distress (BSI-18) before and after cancer treatment and coping (MINI-MAC) and spirituality (FACIT-sp) prior to therapy. A multivariable logistic regression analysis and a Structural Equation Modeling (SEM) were conducted. Between 2019 and 2022, 1807 patients were evaluated, mostly women (54%), average age 64 years. The most frequent cancers were colorectal (30%), breast (25%) and lung (18%). Men had lower levels of anxiety and depression (OR 0.66, 95% CI 0.52–0.84; OR 0.72, 95% CI 0.56–0.93). Colorectal cancer patients experienced less anxiety (OR 0.63, 95% CI 0.43–0.92), depression (OR 0.55, 95% CI 0.37–0.81), and somatization (OR 0.59, 95% CI 0.42–0.83). Patients with localized cancer and spiritual beliefs had reduced psychological distress, whereas those with anxious preoccupation had higher level. SEM revealed a relationship between psychological distress and coping strategies, emphasizing how baseline anxious preoccupation exacerbates post-treatment distress. This study suggests that age, sex, extension and location of cancer, coping and spirituality influence psychological distress in cancer patients. |
| first_indexed | 2024-03-07T15:09:03Z |
| format | Article |
| id | doaj.art-58467d210e9d498c90b639ba8eff1d4b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:09:03Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-58467d210e9d498c90b639ba8eff1d4b2024-03-05T18:43:39ZengNature PortfolioScientific Reports2045-23222024-02-0114111110.1038/s41598-024-53212-yProspective study of predictors for anxiety, depression, and somatization in a sample of 1807 cancer patientsVeronica Velasco-Durantez0Patricia Cruz-Castellanos1Raquel Hernandez2Adan Rodriguez-Gonzalez3Ana Fernandez Montes4Alejandro Gallego5Aranzazu Manzano-Fernandez6Elena Sorribes7Marta Zafra8Alberto Carmona-Bayonas9Caterina Calderon10Paula Jiménez-Fonseca11Department of Medical Oncology, Hospital Universitario Central de Asturias, ISPADepartment of Medical Oncology, Hospital General Universitario de Ciudad RealDepartment of Medical Oncology, Hospital Universitario de CanariasDepartment of Medical Oncology, Hospital Universitario Central de Asturias, ISPADepartment of Medical Oncology, Complejo Hospitalario Universitario de OurenseDepartment of Medical Oncology, Clínica Universidad de NavarraDepartment of Medical Oncology, Hospital Universitario Clínico San CarlosDepartment of Clinical Psychology and Psychobiology, Faculty of Psychology, University of BarcelonaDepartment of Hematology and Medical Oncology, Hospital Universitario Morales MeseguerDepartment of Hematology and Medical Oncology, Hospital Universitario Morales Meseguer, UMU, IMIBDepartment of Clinical Psychology and Psychobiology, Faculty of Psychology, University of BarcelonaDepartment of Medical Oncology, Hospital Universitario Central de Asturias, ISPAAbstract In cancer patients, psychological distress, which encompasses anxiety, depression, and somatization, arises from the complex interplay of emotional and behavioral reactions to the diagnosis and treatment, significantly influencing their functionality and quality of life. The aim was to investigate factors associated with psychological distress in cancer patients. This prospective and multicenter study, conducted by the Spanish Society of Medical Oncology (SEOM), included two cohorts of patients with cancer (localized resected or advanced unresectable). They completed surveys assessing psychological distress (BSI-18) before and after cancer treatment and coping (MINI-MAC) and spirituality (FACIT-sp) prior to therapy. A multivariable logistic regression analysis and a Structural Equation Modeling (SEM) were conducted. Between 2019 and 2022, 1807 patients were evaluated, mostly women (54%), average age 64 years. The most frequent cancers were colorectal (30%), breast (25%) and lung (18%). Men had lower levels of anxiety and depression (OR 0.66, 95% CI 0.52–0.84; OR 0.72, 95% CI 0.56–0.93). Colorectal cancer patients experienced less anxiety (OR 0.63, 95% CI 0.43–0.92), depression (OR 0.55, 95% CI 0.37–0.81), and somatization (OR 0.59, 95% CI 0.42–0.83). Patients with localized cancer and spiritual beliefs had reduced psychological distress, whereas those with anxious preoccupation had higher level. SEM revealed a relationship between psychological distress and coping strategies, emphasizing how baseline anxious preoccupation exacerbates post-treatment distress. This study suggests that age, sex, extension and location of cancer, coping and spirituality influence psychological distress in cancer patients.https://doi.org/10.1038/s41598-024-53212-y |
| spellingShingle | Veronica Velasco-Durantez Patricia Cruz-Castellanos Raquel Hernandez Adan Rodriguez-Gonzalez Ana Fernandez Montes Alejandro Gallego Aranzazu Manzano-Fernandez Elena Sorribes Marta Zafra Alberto Carmona-Bayonas Caterina Calderon Paula Jiménez-Fonseca Prospective study of predictors for anxiety, depression, and somatization in a sample of 1807 cancer patients Scientific Reports |
| title | Prospective study of predictors for anxiety, depression, and somatization in a sample of 1807 cancer patients |
| title_full | Prospective study of predictors for anxiety, depression, and somatization in a sample of 1807 cancer patients |
| title_fullStr | Prospective study of predictors for anxiety, depression, and somatization in a sample of 1807 cancer patients |
| title_full_unstemmed | Prospective study of predictors for anxiety, depression, and somatization in a sample of 1807 cancer patients |
| title_short | Prospective study of predictors for anxiety, depression, and somatization in a sample of 1807 cancer patients |
| title_sort | prospective study of predictors for anxiety depression and somatization in a sample of 1807 cancer patients |
| url | https://doi.org/10.1038/s41598-024-53212-y |
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