Impact of the COVID-19 Epidemic on Inhalant Allergen Sensitization in Children
Objective. To explore the impact of non-pharmacological interventions on inhaled allergen sensitization in children during the COVID-19 pandemic. Methods. The positive rate of inhaled allergens, allergens sIgE grade, and multiple sensitization rates before and during the pandemic were analyzed retro...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2024-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2024/5641948 |
| _version_ | 1797348027086667776 |
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| author | Xueshan Huang Min Yang Ma Ye Jun Qiu Yanping Chen |
| author_facet | Xueshan Huang Min Yang Ma Ye Jun Qiu Yanping Chen |
| author_sort | Xueshan Huang |
| collection | DOAJ |
| description | Objective. To explore the impact of non-pharmacological interventions on inhaled allergen sensitization in children during the COVID-19 pandemic. Methods. The positive rate of inhaled allergens, allergens sIgE grade, and multiple sensitization rates before and during the pandemic were analyzed retrospectively in this study. Logistic regression analysis was used to compare the positive rate of allergens before and during the pandemic, using odds ratio (OR) and OR 95% CI to investigate the impact of the pandemic on allergen sensitization. Results. Positive rates of d1 (49.5% vs. 38.5%), d2 (50.2% vs. 32.2%), e2 (10.1% vs. 6.1%), e1 (6.2% vs. 1.7%), mx2 (10.1% vs. 2.7%), sycamore (7.2% vs. 2.1%), w1 (4.0% vs. 1.7%), elm (3.1% vs. 0.6%), w6 (3.0% vs. 1.7%), and u80 (1.3% vs. 0.5%) increased significantly during the COVID-19 pandemic. After adjusting gender, age, season, and other potential influencing factors, the COVID-19 pandemic was found to be a risk factor for the positive rate of d1 (OR = 1.174, 95% CI = 1.015–1.358), d2 (OR = 1.301, 95% CI = 1.093–1.549), e2 (OR = 1.499, 95% CI = 1.280–1.756), mx2 (OR = 3.959, 95% CI = 3.358–4.446), w1 (OR = 1.828, 95% CI = 1.353–2.470, w6 (OR = 1.538, 95% CI = 1.123–2.106)), and u80 (OR = 2.521, 95% CI = 1.413–4.497) (P<0.05). In addition, d1 and d2 allergen sIgE grades increased during the COVID-19 pandemic (d1: χ2 = 9.576, P<0.05; d2: χ2 = 39.063, P<0.05). The proportion of multiple allergies was significantly higher than that before the pandemic, with a statistical significance (χ2 = 1621.815, P<0.05). Conclusion. During the COVID-19 pandemic, non-pharmacological interventions increased the positive rate of both indoor and outdoor allergens in children. The sIgE grade of dust mite allergen and multiple sensitization rates were significantly higher than those before COVID-19. |
| first_indexed | 2024-03-08T11:57:29Z |
| format | Article |
| id | doaj.art-584765640c0d43eca6fd9bc31693fe73 |
| institution | Directory Open Access Journal |
| issn | 2314-7156 |
| language | English |
| last_indexed | 2024-03-08T11:57:29Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj.art-584765640c0d43eca6fd9bc31693fe732024-01-24T00:00:14ZengHindawi LimitedJournal of Immunology Research2314-71562024-01-01202410.1155/2024/5641948Impact of the COVID-19 Epidemic on Inhalant Allergen Sensitization in ChildrenXueshan Huang0Min Yang1Ma Ye2Jun Qiu3Yanping Chen4Postgraduate Cooperative Training Base of Hunan Children’s HospitalDepartment of RespiratoryDepartment of NeonatologyPediatrics Research Institute of Hunan ProvinceDepartment of RespiratoryObjective. To explore the impact of non-pharmacological interventions on inhaled allergen sensitization in children during the COVID-19 pandemic. Methods. The positive rate of inhaled allergens, allergens sIgE grade, and multiple sensitization rates before and during the pandemic were analyzed retrospectively in this study. Logistic regression analysis was used to compare the positive rate of allergens before and during the pandemic, using odds ratio (OR) and OR 95% CI to investigate the impact of the pandemic on allergen sensitization. Results. Positive rates of d1 (49.5% vs. 38.5%), d2 (50.2% vs. 32.2%), e2 (10.1% vs. 6.1%), e1 (6.2% vs. 1.7%), mx2 (10.1% vs. 2.7%), sycamore (7.2% vs. 2.1%), w1 (4.0% vs. 1.7%), elm (3.1% vs. 0.6%), w6 (3.0% vs. 1.7%), and u80 (1.3% vs. 0.5%) increased significantly during the COVID-19 pandemic. After adjusting gender, age, season, and other potential influencing factors, the COVID-19 pandemic was found to be a risk factor for the positive rate of d1 (OR = 1.174, 95% CI = 1.015–1.358), d2 (OR = 1.301, 95% CI = 1.093–1.549), e2 (OR = 1.499, 95% CI = 1.280–1.756), mx2 (OR = 3.959, 95% CI = 3.358–4.446), w1 (OR = 1.828, 95% CI = 1.353–2.470, w6 (OR = 1.538, 95% CI = 1.123–2.106)), and u80 (OR = 2.521, 95% CI = 1.413–4.497) (P<0.05). In addition, d1 and d2 allergen sIgE grades increased during the COVID-19 pandemic (d1: χ2 = 9.576, P<0.05; d2: χ2 = 39.063, P<0.05). The proportion of multiple allergies was significantly higher than that before the pandemic, with a statistical significance (χ2 = 1621.815, P<0.05). Conclusion. During the COVID-19 pandemic, non-pharmacological interventions increased the positive rate of both indoor and outdoor allergens in children. The sIgE grade of dust mite allergen and multiple sensitization rates were significantly higher than those before COVID-19.http://dx.doi.org/10.1155/2024/5641948 |
| spellingShingle | Xueshan Huang Min Yang Ma Ye Jun Qiu Yanping Chen Impact of the COVID-19 Epidemic on Inhalant Allergen Sensitization in Children Journal of Immunology Research |
| title | Impact of the COVID-19 Epidemic on Inhalant Allergen Sensitization in Children |
| title_full | Impact of the COVID-19 Epidemic on Inhalant Allergen Sensitization in Children |
| title_fullStr | Impact of the COVID-19 Epidemic on Inhalant Allergen Sensitization in Children |
| title_full_unstemmed | Impact of the COVID-19 Epidemic on Inhalant Allergen Sensitization in Children |
| title_short | Impact of the COVID-19 Epidemic on Inhalant Allergen Sensitization in Children |
| title_sort | impact of the covid 19 epidemic on inhalant allergen sensitization in children |
| url | http://dx.doi.org/10.1155/2024/5641948 |
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