Evaluation of clinical trials of ethnomedicine used for the treatment of diabetes: A systematic review
Diabetes mellitus (DM) is a widespread metabolic disorder with a yearly 6.7 million deaths worldwide. Several treatment options are available but with common side effects like weight gain, cardiovascular diseases, neurotoxicity, hepatotoxicity, and nephrotoxicity. Therefore, ethnomedicine is gaining...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1176618/full |
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| author | Gul Rehman Elmi Gul Rehman Elmi Gul Rehman Elmi Kamil Anum Kalsoom Saleem Rameesha Fareed Sobia Noreen Haiyan Wei Yongxing Chen Avirup Chakraborty Masood Ur Rehman Shi Liyuan Muhammad Abbas Yongtao Duan |
| author_facet | Gul Rehman Elmi Gul Rehman Elmi Gul Rehman Elmi Kamil Anum Kalsoom Saleem Rameesha Fareed Sobia Noreen Haiyan Wei Yongxing Chen Avirup Chakraborty Masood Ur Rehman Shi Liyuan Muhammad Abbas Yongtao Duan |
| author_sort | Gul Rehman Elmi |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is a widespread metabolic disorder with a yearly 6.7 million deaths worldwide. Several treatment options are available but with common side effects like weight gain, cardiovascular diseases, neurotoxicity, hepatotoxicity, and nephrotoxicity. Therefore, ethnomedicine is gaining the interest of researchers in the treatment of DM. Ethnomedicine works by preventing intestinal absorption and hepatic production of glucose as well as enhancing glucose uptake in muscles and fatty tissues and increasing insulin secretion. A variety of plants have entered clinical trials but very few have gained approval for use. This current study provides an evaluation of such clinical trials. For this purpose, an extensive literature review was performed from a database using keywords like “ethnomedicine diabetes clinical trial”, “clinical trials”, “clinical trial in diabetes”, “diabetes”, “natural products in diabetes”, “ethno-pharmacological relevance of natural products in diabetes”, etc. Clinical trials of 20 plants and natural products were evaluated based on eligibility criteria. Major limitations associated with these clinical trials were a lack of patient compliance, dose-response relationship, and an evaluation of biomarkers with a small sample size and treatment duration. Measures in terms of strict regulations can be considered to achieve quality clinical trials. A specific goal of this systematic review is to discuss DM treatment through ethnomedicine based on recent clinical trials of the past 7 years. |
| first_indexed | 2024-04-09T19:09:07Z |
| format | Article |
| id | doaj.art-5848a2a05fd04d14a674de77718095b3 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-09T19:09:07Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-5848a2a05fd04d14a674de77718095b32023-04-07T04:20:40ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-04-011410.3389/fphar.2023.11766181176618Evaluation of clinical trials of ethnomedicine used for the treatment of diabetes: A systematic reviewGul Rehman Elmi0Gul Rehman Elmi1Gul Rehman Elmi2Kamil Anum3Kalsoom Saleem4Rameesha Fareed5Sobia Noreen6Haiyan Wei7Yongxing Chen8Avirup Chakraborty9Masood Ur Rehman10Shi Liyuan11Muhammad Abbas12Yongtao Duan13Henan Provincial Key Laboratory of Pediatric Hematology, Children’s Genetics and Metabolic Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, ChinaRiphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, PakistanDepartment of Pharmacy, IQRA University Islamabad Campus (Chak Shahzad), Islamabad, PakistanRiphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, PakistanRiphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, PakistanRiphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, PakistanDepartment of Pharmaceutical Technology, Institute of Pharmacy, University of Innsbruck, Innsbruck, AustriaHenan Provincial Key Laboratory of Pediatric Hematology, Children’s Genetics and Metabolic Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, ChinaHenan Provincial Key Laboratory of Pediatric Hematology, Children’s Genetics and Metabolic Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, ChinaDepartment of Neurosurgery, University of Florida, Gainesville, FL, United StatesRiphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, PakistanInstitute of Translational Medicine, Zhejiang Shuren University, Hangzhou, ChinaInstitute of Translational Medicine, Zhejiang Shuren University, Hangzhou, ChinaHenan Provincial Key Laboratory of Pediatric Hematology, Children’s Genetics and Metabolic Diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, ChinaDiabetes mellitus (DM) is a widespread metabolic disorder with a yearly 6.7 million deaths worldwide. Several treatment options are available but with common side effects like weight gain, cardiovascular diseases, neurotoxicity, hepatotoxicity, and nephrotoxicity. Therefore, ethnomedicine is gaining the interest of researchers in the treatment of DM. Ethnomedicine works by preventing intestinal absorption and hepatic production of glucose as well as enhancing glucose uptake in muscles and fatty tissues and increasing insulin secretion. A variety of plants have entered clinical trials but very few have gained approval for use. This current study provides an evaluation of such clinical trials. For this purpose, an extensive literature review was performed from a database using keywords like “ethnomedicine diabetes clinical trial”, “clinical trials”, “clinical trial in diabetes”, “diabetes”, “natural products in diabetes”, “ethno-pharmacological relevance of natural products in diabetes”, etc. Clinical trials of 20 plants and natural products were evaluated based on eligibility criteria. Major limitations associated with these clinical trials were a lack of patient compliance, dose-response relationship, and an evaluation of biomarkers with a small sample size and treatment duration. Measures in terms of strict regulations can be considered to achieve quality clinical trials. A specific goal of this systematic review is to discuss DM treatment through ethnomedicine based on recent clinical trials of the past 7 years.https://www.frontiersin.org/articles/10.3389/fphar.2023.1176618/fullethnomedicinediabetestreatmentclinical trailoutcomesystematic review |
| spellingShingle | Gul Rehman Elmi Gul Rehman Elmi Gul Rehman Elmi Kamil Anum Kalsoom Saleem Rameesha Fareed Sobia Noreen Haiyan Wei Yongxing Chen Avirup Chakraborty Masood Ur Rehman Shi Liyuan Muhammad Abbas Yongtao Duan Evaluation of clinical trials of ethnomedicine used for the treatment of diabetes: A systematic review Frontiers in Pharmacology ethnomedicine diabetes treatment clinical trail outcome systematic review |
| title | Evaluation of clinical trials of ethnomedicine used for the treatment of diabetes: A systematic review |
| title_full | Evaluation of clinical trials of ethnomedicine used for the treatment of diabetes: A systematic review |
| title_fullStr | Evaluation of clinical trials of ethnomedicine used for the treatment of diabetes: A systematic review |
| title_full_unstemmed | Evaluation of clinical trials of ethnomedicine used for the treatment of diabetes: A systematic review |
| title_short | Evaluation of clinical trials of ethnomedicine used for the treatment of diabetes: A systematic review |
| title_sort | evaluation of clinical trials of ethnomedicine used for the treatment of diabetes a systematic review |
| topic | ethnomedicine diabetes treatment clinical trail outcome systematic review |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1176618/full |
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