Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)
The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2023-01-01
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| Series: | EPJ Nuclear Sciences & Technologies |
| Online Access: | https://www.epj-n.org/articles/epjn/full_html/2023/01/epjn220074/epjn220074.html |
| _version_ | 1797807641259409408 |
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| author | Thierry-Chef Isabelle Timmermann Beate Journy Neige Bernier Marie-Odile McNally Richard Dabin Jérémie Brualla Lorenzo Haghdoost Siamak Sarukhan Adelaida Haustermans Karin De Wit Inge Isebaert Sofie Lassen-Ramshad Yasmin Tram Henriksen Louise Høyer Morten Toussaint Laura Boissonnat Guillaume Thariat Juliette Demoor-Goldschmidt Charlotte Haddy Nadia Bolle Stéphanie Fresneau Brice Belhout Amel Dreger Steffen Zeeb Hajo Grazia Andreassi Maria Campolo Jonica Picano Eugenio Jahnen Andreas Ronckers Cécile Maduro John H. Kjaerheim Kristina Døhlen Gaute Robsahm Trude Eid Olerud Hilde M. Thevathas Utheya Salini Afroz Susmita Helge Østerås Bjørn Schneider Uwe Walsh Linda Dumas Agnès Jackson Angéla Rage Estelle De Saint-Hubert Marijke Hardy Richard Bäumer Christian Steinmeier Theresa Botzenhardt Suzan Wette Martina Ortiz Rodney Chumak Vadim |
| author_facet | Thierry-Chef Isabelle Timmermann Beate Journy Neige Bernier Marie-Odile McNally Richard Dabin Jérémie Brualla Lorenzo Haghdoost Siamak Sarukhan Adelaida Haustermans Karin De Wit Inge Isebaert Sofie Lassen-Ramshad Yasmin Tram Henriksen Louise Høyer Morten Toussaint Laura Boissonnat Guillaume Thariat Juliette Demoor-Goldschmidt Charlotte Haddy Nadia Bolle Stéphanie Fresneau Brice Belhout Amel Dreger Steffen Zeeb Hajo Grazia Andreassi Maria Campolo Jonica Picano Eugenio Jahnen Andreas Ronckers Cécile Maduro John H. Kjaerheim Kristina Døhlen Gaute Robsahm Trude Eid Olerud Hilde M. Thevathas Utheya Salini Afroz Susmita Helge Østerås Bjørn Schneider Uwe Walsh Linda Dumas Agnès Jackson Angéla Rage Estelle De Saint-Hubert Marijke Hardy Richard Bäumer Christian Steinmeier Theresa Botzenhardt Suzan Wette Martina Ortiz Rodney Chumak Vadim |
| author_sort | Thierry-Chef Isabelle |
| collection | DOAJ |
| description | The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects. |
| first_indexed | 2024-03-13T06:25:41Z |
| format | Article |
| id | doaj.art-5848e4ad4ed94b4b81ed0373a4489aa1 |
| institution | Directory Open Access Journal |
| issn | 2491-9292 |
| language | English |
| last_indexed | 2024-03-13T06:25:41Z |
| publishDate | 2023-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | EPJ Nuclear Sciences & Technologies |
| spelling | doaj.art-5848e4ad4ed94b4b81ed0373a4489aa12023-06-09T09:21:02ZengEDP SciencesEPJ Nuclear Sciences & Technologies2491-92922023-01-0192210.1051/epjn/2023009epjn220074Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project)Thierry-Chef Isabelle0Timmermann Beate1Journy Neige2Bernier Marie-Odile3McNally Richard4Dabin Jérémie5Brualla Lorenzo6Haghdoost Siamak7Sarukhan Adelaida8Haustermans Karin9De Wit Inge10Isebaert Sofie11Lassen-Ramshad Yasmin12Tram Henriksen Louise13Høyer Morten14Toussaint Laura15Boissonnat Guillaume16Thariat Juliette17Demoor-Goldschmidt Charlotte18Haddy Nadia19Bolle Stéphanie20Fresneau Brice21Belhout Amel22Dreger Steffen23Zeeb Hajo24Grazia Andreassi Maria25Campolo Jonica26Picano Eugenio27Jahnen Andreas28Ronckers Cécile29Maduro John H.30Kjaerheim Kristina31Døhlen Gaute32Robsahm Trude Eid33Olerud Hilde M.34Thevathas Utheya Salini35Afroz Susmita36Helge Østerås Bjørn37Schneider Uwe38Walsh Linda39Dumas Agnès40Jackson Angéla41Rage Estelle42De Saint-Hubert Marijke43Hardy Richard44Bäumer Christian45Steinmeier Theresa46Botzenhardt Suzan47Wette Martina48Ortiz Rodney49Chumak Vadim50Barcelona Institute for Global Health (ISGlobal)University Hospital Essen (UK Essen)French National Institute of Health and Medical Research (Inserm), Gustave RoussyInstitut de Radioprotection et de Sûreté Nucléaire (IRSN)Population Health Science Institute, Newcastle University, Sir James Spence Institute, Royal Victoria InfirmaryBelgian Nuclear Research Centre (SCK CEN)West German Proton Therapy Centre Essen (WPE)Stockholm University (SU), Universitetsvagen 10Barcelona Institute for Global Health (ISGlobal)Katholieke Universiteit Leuven (KU Leuven)Katholieke Universiteit Leuven (KU Leuven)Katholieke Universiteit Leuven (KU Leuven)Department of Pediatric and Adolescent Medicine, Aarhus University Hospital (AUH)Department of Pediatric and Adolescent Medicine, Aarhus University Hospital (AUH)Aarhus University (AU)Aarhus University (AU)Commissariat à l’Énergie Atomique & aux Énergies Alternatives (CEA)Centre Régional François Baclesse (CRFB)French National Institute of Health and Medical Research (Inserm), Gustave RoussyGustave Roussy (GR)Gustave Roussy (GR)Gustave Roussy (GR)Gustave Roussy (GR)Leibniz-Institute for Prevention Research & Epidemiology (BIPS)Leibniz-Institute for Prevention Research & Epidemiology (BIPS)Institute of Clinical Physiology – National Research Council (IFC-CNR)Institute of Clinical Physiology – National Research Council (IFC-CNR)Institute of Clinical Physiology – National Research Council (IFC-CNR)Luxembourg Institute of Science and Technology (LIST)Princess Maxima Center for Paediatric Oncology (PMC)University of Groningen, University Medical Center Groningen (UMCG)Cancer Registry of Norway, Department of ResearchDepartment of Pediatric Cardiology, Oslo University (OUS)Cancer Registry of Norway, Department of ResearchUniversity of South-Eastern Norway (USN)University of South-Eastern Norway (USN)University of South-Eastern Norway (USN)Department of Physics and Computational Radiology, Oslo University (OUS)University of Zurich (UZH)University of Zurich (UZH)French National Institute of Health and Medical Research (Inserm), Gustave RoussyFrench National Institute of Health and Medical Research (Inserm), Gustave RoussyInstitut de Radioprotection et de Sûreté Nucléaire (IRSN)Belgian Nuclear Research Centre (SCK CEN)Population Health Science Institute, Newcastle University, Sir James Spence Institute, Royal Victoria InfirmaryWest German Proton Therapy Centre Essen (WPE)Department of Particle Therapy – University Hospital Essen, West German Cancer Centre (WTZ)Department of Particle Therapy – University Hospital Essen, West German Cancer Centre (WTZ)Department of Particle Therapy – University Hospital Essen, West German Cancer Centre (WTZ)Barcelona Institute for Global Health (ISGlobal)National Research Center for Radiation Medicine (NRCRM)The use of ionising radiation (IR) for medical diagnosis and treatment procedures has had a major impact on the survival of paediatric patients. Although the benefits of these techniques lead to efficient health care, evaluation of potential associated long-term health effects is required. HARMONIC aims to better understand the increased risk of cancer and non-cancer effects after exposure to medical IR in children with cancer treated with modern external beam radiotherapy (EBRT) – radiation energy in MeV range – and in children with cardiac defects diagnosed and treated with cardiac fluoroscopy procedures (CFP) – radiation energy in keV range. The project investigates, among survivors of paediatric cancer, potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life and second (and subsequent) primary cancer (SPC). The cardiac component builds a pooled cohort of approximately 90 000 paediatric patients who underwent CFP during childhood and adolescence to investigate cancer risk following exposure to IR and explore the potential effects of conditions predisposing to cancer. HARMONIC develops software tools to allow dose reconstruction in both EBRT and CFP to enable epidemiological investigations and future optimisation of treatments. With the creation of a biobank of blood and saliva samples, HARMONIC aims to provide a mechanistic understanding of radiation-induced adverse health effects and identify potential biomarkers that can predict these effects.https://www.epj-n.org/articles/epjn/full_html/2023/01/epjn220074/epjn220074.html |
| spellingShingle | Thierry-Chef Isabelle Timmermann Beate Journy Neige Bernier Marie-Odile McNally Richard Dabin Jérémie Brualla Lorenzo Haghdoost Siamak Sarukhan Adelaida Haustermans Karin De Wit Inge Isebaert Sofie Lassen-Ramshad Yasmin Tram Henriksen Louise Høyer Morten Toussaint Laura Boissonnat Guillaume Thariat Juliette Demoor-Goldschmidt Charlotte Haddy Nadia Bolle Stéphanie Fresneau Brice Belhout Amel Dreger Steffen Zeeb Hajo Grazia Andreassi Maria Campolo Jonica Picano Eugenio Jahnen Andreas Ronckers Cécile Maduro John H. Kjaerheim Kristina Døhlen Gaute Robsahm Trude Eid Olerud Hilde M. Thevathas Utheya Salini Afroz Susmita Helge Østerås Bjørn Schneider Uwe Walsh Linda Dumas Agnès Jackson Angéla Rage Estelle De Saint-Hubert Marijke Hardy Richard Bäumer Christian Steinmeier Theresa Botzenhardt Suzan Wette Martina Ortiz Rodney Chumak Vadim Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project) EPJ Nuclear Sciences & Technologies |
| title | Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project) |
| title_full | Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project) |
| title_fullStr | Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project) |
| title_full_unstemmed | Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project) |
| title_short | Health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy (The HARMONIC project) |
| title_sort | health effects of ionising radiation in paediatrics undergoing either cardiac fluoroscopy or modern radiotherapy the harmonic project |
| url | https://www.epj-n.org/articles/epjn/full_html/2023/01/epjn220074/epjn220074.html |
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