The Na+/Ca2+ exchanger NCX3 mediates Ca2+ entry into matrix vesicles to facilitate initial steps of mineralization in osteoblasts

The Na+/Ca2+ exchanger NCX3 mediates Ca2+ entry into matrix vesicles to facilitate initial steps of mineralization in osteoblasts

Abstract Matrix vesicles (MVs) provide the initial site for amorphous hydroxyapatite (HA) formation within mineralizing osteoblasts. Although Na+/Ca2+ exchanger isoform‐3 (NCX3, SLC8A3) was presumed to function as major Ca2+ transporter responsible for Ca2+ extrusion out of osteoblast into the calci...

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Bibliographic Details
Main Authors: Irshad A. Sheikh, Monica T. Midura‐Kiela, André Herchuelz, Sophie Sokolow, Pawel R. Kiela, Fayez K. Ghishan
Format: Article
Language:English
Published: Wiley 2024-06-01
Series:Journal of Extracellular Vesicles
Subjects:
matrix vesicles
mineralization
NCX3
osteoblasts
Online Access:https://doi.org/10.1002/jev2.12450

Internet

https://doi.org/10.1002/jev2.12450

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