Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis
Abstract We investigated and characterized the prevalence of dry eye disease (DED) in Parkinson’s disease (PD). PubMed and EMBASE databases were searched for relevant studies between January 1, 1979 and March 10, 2022. Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checkli...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-22037-y |
| _version_ | 1798044363134074880 |
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| author | Ken Nagino Jaemyoung Sung Genko Oyama Motoshi Hayano Nobutaka Hattori Yuichi Okumura Kenta Fujio Yasutsugu Akasaki Tianxiang Huang Akie Midorikawa-Inomata Keiichi Fujimoto Atsuko Eguchi Shokirova Hurramhon Maria Miura Mizu Ohno Kunihiko Hirosawa Yuki Morooka Akira Murakami Hiroyuki Kobayashi Takenori Inomata |
| author_facet | Ken Nagino Jaemyoung Sung Genko Oyama Motoshi Hayano Nobutaka Hattori Yuichi Okumura Kenta Fujio Yasutsugu Akasaki Tianxiang Huang Akie Midorikawa-Inomata Keiichi Fujimoto Atsuko Eguchi Shokirova Hurramhon Maria Miura Mizu Ohno Kunihiko Hirosawa Yuki Morooka Akira Murakami Hiroyuki Kobayashi Takenori Inomata |
| author_sort | Ken Nagino |
| collection | DOAJ |
| description | Abstract We investigated and characterized the prevalence of dry eye disease (DED) in Parkinson’s disease (PD). PubMed and EMBASE databases were searched for relevant studies between January 1, 1979 and March 10, 2022. Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Study-specific estimates were combined using the DerSimonian–Laird random-effects model. Prevalence of subjective DED symptoms in patients with PD and mean differences in blink rate, corneal thickness, tear film breakup time, and tear secretion volume on Schirmer test I were compared to those in controls. Of 383 studies, 13 (1519 patients with PD) and 12 were included in qualitative and quantitative syntheses, respectively. Meta-analysis revealed a 61.1% prevalence of subjective DED symptoms in PD and that, compared with controls, patients with PD had significantly lower blink rate, thinner corneal thickness, shorter tear film breakup time, and lower tear secretion volumes on Schirmer test I, without and with anesthesia. |
| first_indexed | 2024-04-11T23:02:38Z |
| format | Article |
| id | doaj.art-584c3ef0e673408aaea39b6fecdff99d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-11T23:02:38Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-584c3ef0e673408aaea39b6fecdff99d2022-12-22T03:58:05ZengNature PortfolioScientific Reports2045-23222022-11-0112111210.1038/s41598-022-22037-yPrevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysisKen Nagino0Jaemyoung Sung1Genko Oyama2Motoshi Hayano3Nobutaka Hattori4Yuichi Okumura5Kenta Fujio6Yasutsugu Akasaki7Tianxiang Huang8Akie Midorikawa-Inomata9Keiichi Fujimoto10Atsuko Eguchi11Shokirova Hurramhon12Maria Miura13Mizu Ohno14Kunihiko Hirosawa15Yuki Morooka16Akira Murakami17Hiroyuki Kobayashi18Takenori Inomata19Department of Hospital Administration, Juntendo University Graduate School of MedicineDepartment of Digital Medicine, Juntendo University Graduate School of MedicineDepartment of Neurology, Juntendo University Graduate School of MedicineDepartment of Neuropsychiatry, Keio University School of MedicineDepartment of Neurology, Juntendo University Graduate School of MedicineDepartment of Digital Medicine, Juntendo University Graduate School of MedicineDepartment of Digital Medicine, Juntendo University Graduate School of MedicineDepartment of Digital Medicine, Juntendo University Graduate School of MedicineDepartment of Digital Medicine, Juntendo University Graduate School of MedicineDepartment of Hospital Administration, Juntendo University Graduate School of MedicineDepartment of Digital Medicine, Juntendo University Graduate School of MedicineDepartment of Hospital Administration, Juntendo University Graduate School of MedicineDepartment of Digital Medicine, Juntendo University Graduate School of MedicineDepartment of Digital Medicine, Juntendo University Graduate School of MedicineDepartment of Digital Medicine, Juntendo University Graduate School of MedicineDepartment of Digital Medicine, Juntendo University Graduate School of MedicineDepartment of Digital Medicine, Juntendo University Graduate School of MedicineDepartment of Digital Medicine, Juntendo University Graduate School of MedicineDepartment of Hospital Administration, Juntendo University Graduate School of MedicineDepartment of Hospital Administration, Juntendo University Graduate School of MedicineAbstract We investigated and characterized the prevalence of dry eye disease (DED) in Parkinson’s disease (PD). PubMed and EMBASE databases were searched for relevant studies between January 1, 1979 and March 10, 2022. Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Study-specific estimates were combined using the DerSimonian–Laird random-effects model. Prevalence of subjective DED symptoms in patients with PD and mean differences in blink rate, corneal thickness, tear film breakup time, and tear secretion volume on Schirmer test I were compared to those in controls. Of 383 studies, 13 (1519 patients with PD) and 12 were included in qualitative and quantitative syntheses, respectively. Meta-analysis revealed a 61.1% prevalence of subjective DED symptoms in PD and that, compared with controls, patients with PD had significantly lower blink rate, thinner corneal thickness, shorter tear film breakup time, and lower tear secretion volumes on Schirmer test I, without and with anesthesia.https://doi.org/10.1038/s41598-022-22037-y |
| spellingShingle | Ken Nagino Jaemyoung Sung Genko Oyama Motoshi Hayano Nobutaka Hattori Yuichi Okumura Kenta Fujio Yasutsugu Akasaki Tianxiang Huang Akie Midorikawa-Inomata Keiichi Fujimoto Atsuko Eguchi Shokirova Hurramhon Maria Miura Mizu Ohno Kunihiko Hirosawa Yuki Morooka Akira Murakami Hiroyuki Kobayashi Takenori Inomata Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis Scientific Reports |
| title | Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis |
| title_full | Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis |
| title_fullStr | Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis |
| title_full_unstemmed | Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis |
| title_short | Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis |
| title_sort | prevalence and characteristics of dry eye disease in parkinson s disease a systematic review and meta analysis |
| url | https://doi.org/10.1038/s41598-022-22037-y |
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