Low miR‐19b‐1‐5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio‐ Cerebrovascular Events in Patients With Acute Coronary Syndrome
Background Because of a nonresponse to aspirin (aspirin resistance), patients with acute coronary syndrome (ACS) are at increased risk of developing recurrent event. The in vitro platelet function tests have potential limitations, making them unsuitable for the detection of aspirin resistance. We in...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.120.017120 |
| _version_ | 1811333622720888832 |
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| author | Sandeep Singh Maurice W. J. de Ronde Esther E. Creemers Ingeborg Van der Made Roelien Meijering Mark Y. Chan Sock Hwee Tan Chee Tang Chin A. Mark Richards Richard W. Troughton Alan Yean Yip Fong Bryan P. Yan Sara‐Joan Pinto‐Sietsma |
| author_facet | Sandeep Singh Maurice W. J. de Ronde Esther E. Creemers Ingeborg Van der Made Roelien Meijering Mark Y. Chan Sock Hwee Tan Chee Tang Chin A. Mark Richards Richard W. Troughton Alan Yean Yip Fong Bryan P. Yan Sara‐Joan Pinto‐Sietsma |
| author_sort | Sandeep Singh |
| collection | DOAJ |
| description | Background Because of a nonresponse to aspirin (aspirin resistance), patients with acute coronary syndrome (ACS) are at increased risk of developing recurrent event. The in vitro platelet function tests have potential limitations, making them unsuitable for the detection of aspirin resistance. We investigated whether miR‐19b‐1‐5p could be utilized as a biomarker for aspirin resistance and future major adverse cardio‐cerebrovascular (MACCE) events in patients with ACS. Methods and Results In this cohort study, patients with ACS were enrolled from multiple tertiary hospitals in Christchurch, Hong Kong, Sarawak, and Singapore between 2011 and 2015. MiR‐19b‐1‐5p expression was measured from buffy coat of patients with ACS (n=945) by reverse transcription quantitative polymerase chain reaction. Platelet function was determined by Multiplate aggregometry testing. MACCE was collected over a mean follow‐up time of 1.01±0.43 years. Low miR‐19b‐1‐5p expression was found to be related to aspirin resistance as could be observed from sustained platelet aggregation in the presence of aspirin (‐Log‐miR‐19b‐1‐5p, [unstandardized beta, 44.50; 95% CI, 2.20–86.80; P<0.05]), even after adjusting for age, sex, ethnicity, and prior history of stroke. Lower miR‐19b‐1‐5p expression was independently associated with a higher risk of MACCE (‐Log‐miR‐19b‐1‐5p, [hazard ratio, 1.85; 95% CI, 1.23–2.80; P<0.05]). Furthermore, a significant interaction was noted between the inverse miR‐19b‐1‐5p expression and family history of premature coronary artery disease (P=0.01) on the risk of MACCE. Conclusions Lower miR‐19b‐1‐5p expression was found to be associated with sustained platelet aggregation on aspirin, and a higher risk of MACCE in patients with ACS. Therefore, miR‐19b‐1‐5p could be a suitable marker for aspirin resistance and might predict recurrence of MACCE in patients with ACS. |
| first_indexed | 2024-04-13T16:55:40Z |
| format | Article |
| id | doaj.art-584c4a0e2e3e48f1875f932652959211 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-04-13T16:55:40Z |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-584c4a0e2e3e48f1875f9326529592112022-12-22T02:38:49ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802021-01-0110210.1161/JAHA.120.017120Low miR‐19b‐1‐5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio‐ Cerebrovascular Events in Patients With Acute Coronary SyndromeSandeep Singh0Maurice W. J. de Ronde1Esther E. Creemers2Ingeborg Van der Made3Roelien Meijering4Mark Y. Chan5Sock Hwee Tan6Chee Tang Chin7A. Mark Richards8Richard W. Troughton9Alan Yean Yip Fong10Bryan P. Yan11Sara‐Joan Pinto‐Sietsma12Departments of Clinical Epidemiology, Biostatistics and Bio‐informaticsAmsterdam UMC, location AMC Amsterdam The NetherlandsDepartments of Clinical Epidemiology, Biostatistics and Bio‐informaticsAmsterdam UMC, location AMC Amsterdam The NetherlandsDepartment of Experimental CardiologyAmsterdam UMC, location AMC Amsterdam The NetherlandsDepartment of Experimental CardiologyAmsterdam UMC, location AMC Amsterdam The NetherlandsACS Biomarker B.V. Amsterdam The NetherlandsThe National University Heart Center Singapore SingaporeThe National University Heart Center Singapore SingaporeProgram in Cardiovascular and Metabolic Disorders Duke‐National University of SingaporeGraduate Medical School Singapore SingaporeCardiovascular Research InstituteYong Loo Lin School of MedicineNational University of Singapore Singapore SingaporeChristchurch Heart InstituteUniversity of Otago Christchurch New ZealandClinical Research Centre Sarawak General Hospital Kuching MalaysiaDepartment of Medicine & Therapeutics The Chinese University of Hong Kong Hong Kong ChinaDepartments of Clinical Epidemiology, Biostatistics and Bio‐informaticsAmsterdam UMC, location AMC Amsterdam The NetherlandsBackground Because of a nonresponse to aspirin (aspirin resistance), patients with acute coronary syndrome (ACS) are at increased risk of developing recurrent event. The in vitro platelet function tests have potential limitations, making them unsuitable for the detection of aspirin resistance. We investigated whether miR‐19b‐1‐5p could be utilized as a biomarker for aspirin resistance and future major adverse cardio‐cerebrovascular (MACCE) events in patients with ACS. Methods and Results In this cohort study, patients with ACS were enrolled from multiple tertiary hospitals in Christchurch, Hong Kong, Sarawak, and Singapore between 2011 and 2015. MiR‐19b‐1‐5p expression was measured from buffy coat of patients with ACS (n=945) by reverse transcription quantitative polymerase chain reaction. Platelet function was determined by Multiplate aggregometry testing. MACCE was collected over a mean follow‐up time of 1.01±0.43 years. Low miR‐19b‐1‐5p expression was found to be related to aspirin resistance as could be observed from sustained platelet aggregation in the presence of aspirin (‐Log‐miR‐19b‐1‐5p, [unstandardized beta, 44.50; 95% CI, 2.20–86.80; P<0.05]), even after adjusting for age, sex, ethnicity, and prior history of stroke. Lower miR‐19b‐1‐5p expression was independently associated with a higher risk of MACCE (‐Log‐miR‐19b‐1‐5p, [hazard ratio, 1.85; 95% CI, 1.23–2.80; P<0.05]). Furthermore, a significant interaction was noted between the inverse miR‐19b‐1‐5p expression and family history of premature coronary artery disease (P=0.01) on the risk of MACCE. Conclusions Lower miR‐19b‐1‐5p expression was found to be associated with sustained platelet aggregation on aspirin, and a higher risk of MACCE in patients with ACS. Therefore, miR‐19b‐1‐5p could be a suitable marker for aspirin resistance and might predict recurrence of MACCE in patients with ACS.https://www.ahajournals.org/doi/10.1161/JAHA.120.017120acute coronary syndromeaspirin resistancebiomarkerscoronary artery diseasemicroRNAs |
| spellingShingle | Sandeep Singh Maurice W. J. de Ronde Esther E. Creemers Ingeborg Van der Made Roelien Meijering Mark Y. Chan Sock Hwee Tan Chee Tang Chin A. Mark Richards Richard W. Troughton Alan Yean Yip Fong Bryan P. Yan Sara‐Joan Pinto‐Sietsma Low miR‐19b‐1‐5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio‐ Cerebrovascular Events in Patients With Acute Coronary Syndrome Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease acute coronary syndrome aspirin resistance biomarkers coronary artery disease microRNAs |
| title | Low miR‐19b‐1‐5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio‐ Cerebrovascular Events in Patients With Acute Coronary Syndrome |
| title_full | Low miR‐19b‐1‐5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio‐ Cerebrovascular Events in Patients With Acute Coronary Syndrome |
| title_fullStr | Low miR‐19b‐1‐5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio‐ Cerebrovascular Events in Patients With Acute Coronary Syndrome |
| title_full_unstemmed | Low miR‐19b‐1‐5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio‐ Cerebrovascular Events in Patients With Acute Coronary Syndrome |
| title_short | Low miR‐19b‐1‐5p Expression Is Related to Aspirin Resistance and Major Adverse Cardio‐ Cerebrovascular Events in Patients With Acute Coronary Syndrome |
| title_sort | low mir 19b 1 5p expression is related to aspirin resistance and major adverse cardio cerebrovascular events in patients with acute coronary syndrome |
| topic | acute coronary syndrome aspirin resistance biomarkers coronary artery disease microRNAs |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.120.017120 |
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