Chitosan-G-Glycidyl Methacrylate/Au Nanocomposites Promote Accelerated Skin Wound Healing
Herein, we report the synthesis of Au nanoparticles (AuNPs) in chitosan (CTS) solution by chemically reducing HAuCl<sub>4</sub>. CTS was further functionalized with glycidyl methacrylate (chitosan-g-glycidyl methacrylate/AuNP, CTS-g-GMA/AuNP) to improve the mechanical properties for cell...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/9/1855 |
| _version_ | 1797483599893626880 |
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| author | Héctor A. López-Muñoz Mauricio Lopez-Romero Moises A. Franco-Molina Alejandro Manzano-Ramirez Cristina Velasquillo Beatriz Liliana España-Sanchez Ana Laura Martinez-Hernandez Hayde Vergara-Castañeda Astrid Giraldo-Betancur Sarai Favela Rogelio Rodriguez-Rodriguez Juan Carlos Mixteco Juan Carlos Tapia-Picazo Diana G. Zarate-Triviño Evgeny Prokhorov Gabriel Luna-Barcenas |
| author_facet | Héctor A. López-Muñoz Mauricio Lopez-Romero Moises A. Franco-Molina Alejandro Manzano-Ramirez Cristina Velasquillo Beatriz Liliana España-Sanchez Ana Laura Martinez-Hernandez Hayde Vergara-Castañeda Astrid Giraldo-Betancur Sarai Favela Rogelio Rodriguez-Rodriguez Juan Carlos Mixteco Juan Carlos Tapia-Picazo Diana G. Zarate-Triviño Evgeny Prokhorov Gabriel Luna-Barcenas |
| author_sort | Héctor A. López-Muñoz |
| collection | DOAJ |
| description | Herein, we report the synthesis of Au nanoparticles (AuNPs) in chitosan (CTS) solution by chemically reducing HAuCl<sub>4</sub>. CTS was further functionalized with glycidyl methacrylate (chitosan-g-glycidyl methacrylate/AuNP, CTS-g-GMA/AuNP) to improve the mechanical properties for cellular regeneration requirements of CTS-g-GMA/AuNP. Our nanocomposites promote excellent cellular viability and have a positive effect on cytokine regulation in the inflammatory and anti-inflammatory response of skin cells. After 40 days of nanocomposite exposure to a skin wound, we showed that our films have a greater skin wound healing capacity than a commercial film (TheraForm<sup>®</sup>), and the presence of the collagen allows better cosmetic ave aspects in skin regeneration in comparison with a nanocomposite with an absence of this protein. Electrical percolation phenomena in such nanocomposites were used as guiding tools for the best nanocomposite performance. Our results suggest that chitosan-based Au nanocomposites show great potential for skin wound repair. |
| first_indexed | 2024-03-09T22:50:17Z |
| format | Article |
| id | doaj.art-584c9cf8560040aab38a448c3cfa2ebf |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T22:50:17Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-584c9cf8560040aab38a448c3cfa2ebf2023-11-23T18:21:48ZengMDPI AGPharmaceutics1999-49232022-09-01149185510.3390/pharmaceutics14091855Chitosan-G-Glycidyl Methacrylate/Au Nanocomposites Promote Accelerated Skin Wound HealingHéctor A. López-Muñoz0Mauricio Lopez-Romero1Moises A. Franco-Molina2Alejandro Manzano-Ramirez3Cristina Velasquillo4Beatriz Liliana España-Sanchez5Ana Laura Martinez-Hernandez6Hayde Vergara-Castañeda7Astrid Giraldo-Betancur8Sarai Favela9Rogelio Rodriguez-Rodriguez10Juan Carlos Mixteco11Juan Carlos Tapia-Picazo12Diana G. Zarate-Triviño13Evgeny Prokhorov14Gabriel Luna-Barcenas15Nanosciences Program, Cinvestav, Ciudad de Mexico 07360, CDMX, MexicoCinvestav Queretaro, Queretaro 76230, QE, MexicoImmunology and Virology Department, Biological Sciences Faculty, Universidad Autonoma de Nuevo León, San Nicolás de los Garza 66450, NL, MexicoCinvestav Queretaro, Queretaro 76230, QE, MexicoInstituto Nacional de Rehabilitacion, Ciudad de Mexico 14389, CDMX, MexicoCONACYT—CIDETEQ, SC, Pedro Escobedo 76703, QE, MexicoTecnologico Nacional de Mexito-Instituto Tecnologico de Queretaro, Queretaro 76000, QE, MexicoFacultad de Medicina, Universidad Autonoma de Queretaro, Queretaro 76176, QE, MexicoCONACYT—Cinvestav Queretaro, Queretaro 76230, QRO, MexicoInstituto de Ingenieria y Tecnologia, Universidad Autonoma de Ciudad Juarez, Ciudad Juarez 38584, CHIH, MexicoCentro Universitario de los Valles, Universidad de Guadalajara, Ameca 46600, JA, MexicoCentro Universitario de los Valles, Universidad de Guadalajara, Ameca 46600, JA, MexicoTecnologico Nacional de Mexico-Instituto Tecnologico de Aguascalientes, Aguascalientes 20256, AG, MexicoImmunology and Virology Department, Biological Sciences Faculty, Universidad Autonoma de Nuevo León, San Nicolás de los Garza 66450, NL, MexicoCinvestav Queretaro, Queretaro 76230, QE, MexicoCinvestav Queretaro, Queretaro 76230, QE, MexicoHerein, we report the synthesis of Au nanoparticles (AuNPs) in chitosan (CTS) solution by chemically reducing HAuCl<sub>4</sub>. CTS was further functionalized with glycidyl methacrylate (chitosan-g-glycidyl methacrylate/AuNP, CTS-g-GMA/AuNP) to improve the mechanical properties for cellular regeneration requirements of CTS-g-GMA/AuNP. Our nanocomposites promote excellent cellular viability and have a positive effect on cytokine regulation in the inflammatory and anti-inflammatory response of skin cells. After 40 days of nanocomposite exposure to a skin wound, we showed that our films have a greater skin wound healing capacity than a commercial film (TheraForm<sup>®</sup>), and the presence of the collagen allows better cosmetic ave aspects in skin regeneration in comparison with a nanocomposite with an absence of this protein. Electrical percolation phenomena in such nanocomposites were used as guiding tools for the best nanocomposite performance. Our results suggest that chitosan-based Au nanocomposites show great potential for skin wound repair.https://www.mdpi.com/1999-4923/14/9/1855Au-chitosan nanocompositegold nanoparticlesskin wound |
| spellingShingle | Héctor A. López-Muñoz Mauricio Lopez-Romero Moises A. Franco-Molina Alejandro Manzano-Ramirez Cristina Velasquillo Beatriz Liliana España-Sanchez Ana Laura Martinez-Hernandez Hayde Vergara-Castañeda Astrid Giraldo-Betancur Sarai Favela Rogelio Rodriguez-Rodriguez Juan Carlos Mixteco Juan Carlos Tapia-Picazo Diana G. Zarate-Triviño Evgeny Prokhorov Gabriel Luna-Barcenas Chitosan-G-Glycidyl Methacrylate/Au Nanocomposites Promote Accelerated Skin Wound Healing Pharmaceutics Au-chitosan nanocomposite gold nanoparticles skin wound |
| title | Chitosan-G-Glycidyl Methacrylate/Au Nanocomposites Promote Accelerated Skin Wound Healing |
| title_full | Chitosan-G-Glycidyl Methacrylate/Au Nanocomposites Promote Accelerated Skin Wound Healing |
| title_fullStr | Chitosan-G-Glycidyl Methacrylate/Au Nanocomposites Promote Accelerated Skin Wound Healing |
| title_full_unstemmed | Chitosan-G-Glycidyl Methacrylate/Au Nanocomposites Promote Accelerated Skin Wound Healing |
| title_short | Chitosan-G-Glycidyl Methacrylate/Au Nanocomposites Promote Accelerated Skin Wound Healing |
| title_sort | chitosan g glycidyl methacrylate au nanocomposites promote accelerated skin wound healing |
| topic | Au-chitosan nanocomposite gold nanoparticles skin wound |
| url | https://www.mdpi.com/1999-4923/14/9/1855 |
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