Avian models for brain mechanisms underlying altered social behavior in autism
The current review is an update on experimental approaches in which birds serve as model species for the investigation of typical failure symptoms associated with autism spectrum disorder (ASD). The discussion is focused on deficiencies of social behavior, from social interactions of domestic chicks...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.1032046/full |
| _version_ | 1797989697942716416 |
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| author | András Csillag Ágota Ádám Gergely Zachar |
| author_facet | András Csillag Ágota Ádám Gergely Zachar |
| author_sort | András Csillag |
| collection | DOAJ |
| description | The current review is an update on experimental approaches in which birds serve as model species for the investigation of typical failure symptoms associated with autism spectrum disorder (ASD). The discussion is focused on deficiencies of social behavior, from social interactions of domestic chicks, based on visual and auditory cues, to vocal communication in songbirds. Two groups of pathogenetic/risk factors are discussed: 1) non-genetic (environmental/epigenetic) factors, exemplified by embryonic exposure to valproic acid (VPA), and 2) genetic factors, represented by a list of candidate genes and signaling pathways of diagnostic or predictive value in ASD patients. Given the similarities of birds as experimental models to humans (visual orientation, vocal learning, social cohesions), avian models usefully contribute toward the elucidation of the neural systems and developmental factors underlying ASD, improving the applicability of preclinical results obtained on laboratory rodents. Furthermore, they may predict potential susceptibility factors worthy of investigation (both by animal studies and by monitoring human babies at risk), with potential therapeutic consequence. |
| first_indexed | 2024-04-11T08:24:37Z |
| format | Article |
| id | doaj.art-584d463f2452438998d2e0edc95600ff |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-11T08:24:37Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-584d463f2452438998d2e0edc95600ff2022-12-22T04:34:49ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-10-011310.3389/fphys.2022.10320461032046Avian models for brain mechanisms underlying altered social behavior in autismAndrás CsillagÁgota ÁdámGergely ZacharThe current review is an update on experimental approaches in which birds serve as model species for the investigation of typical failure symptoms associated with autism spectrum disorder (ASD). The discussion is focused on deficiencies of social behavior, from social interactions of domestic chicks, based on visual and auditory cues, to vocal communication in songbirds. Two groups of pathogenetic/risk factors are discussed: 1) non-genetic (environmental/epigenetic) factors, exemplified by embryonic exposure to valproic acid (VPA), and 2) genetic factors, represented by a list of candidate genes and signaling pathways of diagnostic or predictive value in ASD patients. Given the similarities of birds as experimental models to humans (visual orientation, vocal learning, social cohesions), avian models usefully contribute toward the elucidation of the neural systems and developmental factors underlying ASD, improving the applicability of preclinical results obtained on laboratory rodents. Furthermore, they may predict potential susceptibility factors worthy of investigation (both by animal studies and by monitoring human babies at risk), with potential therapeutic consequence.https://www.frontiersin.org/articles/10.3389/fphys.2022.1032046/fullsocial behaviorsongbirdASDdopaminvalproic acidgenes |
| spellingShingle | András Csillag Ágota Ádám Gergely Zachar Avian models for brain mechanisms underlying altered social behavior in autism Frontiers in Physiology social behavior songbird ASD dopamin valproic acid genes |
| title | Avian models for brain mechanisms underlying altered social behavior in autism |
| title_full | Avian models for brain mechanisms underlying altered social behavior in autism |
| title_fullStr | Avian models for brain mechanisms underlying altered social behavior in autism |
| title_full_unstemmed | Avian models for brain mechanisms underlying altered social behavior in autism |
| title_short | Avian models for brain mechanisms underlying altered social behavior in autism |
| title_sort | avian models for brain mechanisms underlying altered social behavior in autism |
| topic | social behavior songbird ASD dopamin valproic acid genes |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.1032046/full |
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