Extensive intratumor regional epigenetic heterogeneity in clear cell renal cell carcinoma targets kidney enhancers and is associated with poor outcome

Extensive intratumor regional epigenetic heterogeneity in clear cell renal cell carcinoma targets kidney enhancers and is associated with poor outcome

Abstract Background Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mutations. CcRCC is unusual for its high frequency of epigenetic regulator...

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Bibliographic Details
Main Authors: Louis Y. El Khoury, Xiaoyu Pan, Ryan A. Hlady, Ryan T. Wagner, Shafiq Shaikh, Liguo Wang, Mitchell R. Humphreys, Erik P. Castle, Melissa L. Stanton, Thai H. Ho, Keith D. Robertson
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Clinical Epigenetics
Subjects:
Clear cell renal cell cancer
Intra-tumor heterogeneity
DNA methylation
5mC
Epigenomics
CNV
Online Access:https://doi.org/10.1186/s13148-023-01471-3

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