Elevated Factor VIII Levels and Shortened APTT in Recurrent Abortions
Introduction: Thrombotic disorders have been found to be associated with recurrent abortions. Several risk factors have been identified. APTT reflects the common pathway and intrinsic pathway of coagulation cascade and hence is a good marker for thrombotic work. Elevated factor VIII: C has also...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2016-01-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/7080/17841_CE[Ra]_F(Sh)_PF1(Bm_Om)_PFA(AK)_PF2(PAG).pdf |
| _version_ | 1819022374441320448 |
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| author | Aysha Ali Pushpavalli Mohan Hana Kareem Mahsheena Kalpaka Muhammed |
| author_facet | Aysha Ali Pushpavalli Mohan Hana Kareem Mahsheena Kalpaka Muhammed |
| author_sort | Aysha Ali |
| collection | DOAJ |
| description | Introduction: Thrombotic disorders have been found to be
associated with recurrent abortions. Several risk factors have
been identified. APTT reflects the common pathway and intrinsic
pathway of coagulation cascade and hence is a good marker for
thrombotic work. Elevated factor VIII: C has also been identified
as risk factor for recurrent miscarriage. This study aims at
identifying association of elevated factor VIII levels, shortened
APTT and recurrent abortions in Indian population as little has
been studied about this and the literature available is also based
on studies done in European population. This study also aims
to find whether shortened APTT can be an independent risk as
well.
Materials and Methods: Women referred to the obstetrics
department with a history of early recurrent early pregnancy loss
(at least three pregnancy losses before 13 weeks of gestation)
were included in this study. Exclusion criteria were elevated
CRP levels, positive antiphospholipid antibodies, endocrine,
immunological or anatomical cause of embryo demise. A total
of 68 cases of recurrent abortion were included in this study,
68 normal pregnant females (<15 weeks of gestation) were also
included as controls with no history of abortion. The age group
of the cases as well as control was 20-45 years. Activated
partial thromboplastin time and factor VIII assay (one stage
APTT based) were done on the blood samples.
Results: Increased factor VIII levels were seen in 25 cases
(36.4%); 19 cases showed shortened APTT (27.3%); 12 cases
showed both increased factor VIII levels as well as shortened
APTT (18%). All risk factors were negative in 36 cases (52.9%).
None of the controls showed elevated factor VIII levels or
shortened APTT. The mean APTT values of the control subjects
was 31.01 and cases were 27.01 (p=0.001). The mean factor VIII
levels of case were 152.85% and control 144.953% (p=0.012).
Conclusion: There was significant association between
recurrent abortions and elevated factor VIII :c levels and
shortened APTT. Shortened APTT was also identified as an
independent risk factor. |
| first_indexed | 2024-12-21T04:21:59Z |
| format | Article |
| id | doaj.art-584f36ab6ed94133a743bfb5cb036e2e |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-21T04:21:59Z |
| publishDate | 2016-01-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-584f36ab6ed94133a743bfb5cb036e2e2022-12-21T19:16:08ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-01-01101EC04EC0610.7860/JCDR/2016/17841.7080Elevated Factor VIII Levels and Shortened APTT in Recurrent AbortionsAysha Ali0Pushpavalli Mohan1Hana Kareem2Mahsheena Kalpaka Muhammed3Associate Professor, Department of Pathology, Karuna Medical College, Palakkad, Kerala, India.Professor, Department of Pathology, Karuna Medical College, Palakkad, Kerala, India.Resident, Department of Pathology, Karuna Medical College, Palakkad, Kerala, India.Resident, Department of Pathology, Karuna Medical College, Palakkad, Kerala, India.Introduction: Thrombotic disorders have been found to be associated with recurrent abortions. Several risk factors have been identified. APTT reflects the common pathway and intrinsic pathway of coagulation cascade and hence is a good marker for thrombotic work. Elevated factor VIII: C has also been identified as risk factor for recurrent miscarriage. This study aims at identifying association of elevated factor VIII levels, shortened APTT and recurrent abortions in Indian population as little has been studied about this and the literature available is also based on studies done in European population. This study also aims to find whether shortened APTT can be an independent risk as well. Materials and Methods: Women referred to the obstetrics department with a history of early recurrent early pregnancy loss (at least three pregnancy losses before 13 weeks of gestation) were included in this study. Exclusion criteria were elevated CRP levels, positive antiphospholipid antibodies, endocrine, immunological or anatomical cause of embryo demise. A total of 68 cases of recurrent abortion were included in this study, 68 normal pregnant females (<15 weeks of gestation) were also included as controls with no history of abortion. The age group of the cases as well as control was 20-45 years. Activated partial thromboplastin time and factor VIII assay (one stage APTT based) were done on the blood samples. Results: Increased factor VIII levels were seen in 25 cases (36.4%); 19 cases showed shortened APTT (27.3%); 12 cases showed both increased factor VIII levels as well as shortened APTT (18%). All risk factors were negative in 36 cases (52.9%). None of the controls showed elevated factor VIII levels or shortened APTT. The mean APTT values of the control subjects was 31.01 and cases were 27.01 (p=0.001). The mean factor VIII levels of case were 152.85% and control 144.953% (p=0.012). Conclusion: There was significant association between recurrent abortions and elevated factor VIII :c levels and shortened APTT. Shortened APTT was also identified as an independent risk factor.https://jcdr.net/articles/PDF/7080/17841_CE[Ra]_F(Sh)_PF1(Bm_Om)_PFA(AK)_PF2(PAG).pdfthrombosiscoagulation studiesone stage factor viii assaypregnancy |
| spellingShingle | Aysha Ali Pushpavalli Mohan Hana Kareem Mahsheena Kalpaka Muhammed Elevated Factor VIII Levels and Shortened APTT in Recurrent Abortions Journal of Clinical and Diagnostic Research thrombosis coagulation studies one stage factor viii assay pregnancy |
| title | Elevated Factor VIII Levels and Shortened APTT in Recurrent Abortions |
| title_full | Elevated Factor VIII Levels and Shortened APTT in Recurrent Abortions |
| title_fullStr | Elevated Factor VIII Levels and Shortened APTT in Recurrent Abortions |
| title_full_unstemmed | Elevated Factor VIII Levels and Shortened APTT in Recurrent Abortions |
| title_short | Elevated Factor VIII Levels and Shortened APTT in Recurrent Abortions |
| title_sort | elevated factor viii levels and shortened aptt in recurrent abortions |
| topic | thrombosis coagulation studies one stage factor viii assay pregnancy |
| url | https://jcdr.net/articles/PDF/7080/17841_CE[Ra]_F(Sh)_PF1(Bm_Om)_PFA(AK)_PF2(PAG).pdf |
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