Allele surfing causes maladaptation in a Pacific salmon of conservation concern.
How various factors, including demography, recombination or genome duplication, may impact the efficacy of natural selection and the burden of deleterious mutations, is a central question in evolutionary biology and genetics. In this study, we show that key evolutionary processes, including variatio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-09-01
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| Series: | PLoS Genetics |
| Online Access: | https://doi.org/10.1371/journal.pgen.1010918 |
| _version_ | 1797660038527975424 |
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| author | Quentin Rougemont Thibault Leroy Eric B Rondeau Ben Koop Louis Bernatchez |
| author_facet | Quentin Rougemont Thibault Leroy Eric B Rondeau Ben Koop Louis Bernatchez |
| author_sort | Quentin Rougemont |
| collection | DOAJ |
| description | How various factors, including demography, recombination or genome duplication, may impact the efficacy of natural selection and the burden of deleterious mutations, is a central question in evolutionary biology and genetics. In this study, we show that key evolutionary processes, including variations in i) effective population size (Ne) ii) recombination rates and iii) chromosome inheritance, have influenced the genetic load and efficacy of selection in Coho salmon (Oncorhynchus kisutch), a widely distributed salmonid species on the west coast of North America. Using whole genome resequencing data from 14 populations at different migratory distances from their southern glacial refugium, we found evidence supporting gene surfing, wherein reduced Ne at the postglacial recolonization front, leads to a decrease in the efficacy of selection and a surf of deleterious alleles in the northernmost populations. Furthermore, our results indicate that recombination rates play a prime role in shaping the load along the genome. Additionally, we identified variation in polyploidy as a contributing factor to within-genome variation of the load. Overall, our results align remarkably well with expectations under the nearly neutral theory of molecular evolution. We discuss the fundamental and applied implications of these findings for evolutionary and conservation genomics. |
| first_indexed | 2024-03-11T18:24:59Z |
| format | Article |
| id | doaj.art-584fc5ffa1614a58b531be3a1f8d0e63 |
| institution | Directory Open Access Journal |
| issn | 1553-7390 1553-7404 |
| language | English |
| last_indexed | 2024-03-11T18:24:59Z |
| publishDate | 2023-09-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj.art-584fc5ffa1614a58b531be3a1f8d0e632023-10-14T05:31:52ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042023-09-01199e101091810.1371/journal.pgen.1010918Allele surfing causes maladaptation in a Pacific salmon of conservation concern.Quentin RougemontThibault LeroyEric B RondeauBen KoopLouis BernatchezHow various factors, including demography, recombination or genome duplication, may impact the efficacy of natural selection and the burden of deleterious mutations, is a central question in evolutionary biology and genetics. In this study, we show that key evolutionary processes, including variations in i) effective population size (Ne) ii) recombination rates and iii) chromosome inheritance, have influenced the genetic load and efficacy of selection in Coho salmon (Oncorhynchus kisutch), a widely distributed salmonid species on the west coast of North America. Using whole genome resequencing data from 14 populations at different migratory distances from their southern glacial refugium, we found evidence supporting gene surfing, wherein reduced Ne at the postglacial recolonization front, leads to a decrease in the efficacy of selection and a surf of deleterious alleles in the northernmost populations. Furthermore, our results indicate that recombination rates play a prime role in shaping the load along the genome. Additionally, we identified variation in polyploidy as a contributing factor to within-genome variation of the load. Overall, our results align remarkably well with expectations under the nearly neutral theory of molecular evolution. We discuss the fundamental and applied implications of these findings for evolutionary and conservation genomics.https://doi.org/10.1371/journal.pgen.1010918 |
| spellingShingle | Quentin Rougemont Thibault Leroy Eric B Rondeau Ben Koop Louis Bernatchez Allele surfing causes maladaptation in a Pacific salmon of conservation concern. PLoS Genetics |
| title | Allele surfing causes maladaptation in a Pacific salmon of conservation concern. |
| title_full | Allele surfing causes maladaptation in a Pacific salmon of conservation concern. |
| title_fullStr | Allele surfing causes maladaptation in a Pacific salmon of conservation concern. |
| title_full_unstemmed | Allele surfing causes maladaptation in a Pacific salmon of conservation concern. |
| title_short | Allele surfing causes maladaptation in a Pacific salmon of conservation concern. |
| title_sort | allele surfing causes maladaptation in a pacific salmon of conservation concern |
| url | https://doi.org/10.1371/journal.pgen.1010918 |
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