Electroacupuncture stimulation improves cognitive ability and regulates metabolic disorders in Alzheimer’s disease model mice: new insights from brown adipose tissue thermogenesis
BackgroundMetabolic defects play a crucial role in Alzheimer’s disease (AD) development. Brown adipose tissue (BAT) has been identified as a novel potential therapeutic target for AD due to its unique role in energy metabolism. Electroacupuncture (EA) shows promise in improving cognitive ability and...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1330565/full |
| _version_ | 1797356949100036096 |
|---|---|
| author | Ting Li Junjian Tian Meng Wu Yuanshuo Tian Zhigang Li |
| author_facet | Ting Li Junjian Tian Meng Wu Yuanshuo Tian Zhigang Li |
| author_sort | Ting Li |
| collection | DOAJ |
| description | BackgroundMetabolic defects play a crucial role in Alzheimer’s disease (AD) development. Brown adipose tissue (BAT) has been identified as a novel potential therapeutic target for AD due to its unique role in energy metabolism. Electroacupuncture (EA) shows promise in improving cognitive ability and brain glucose metabolism in AD, but its effects on peripheral and central metabolism are unclear.MethodsIn this study, SAMP8 mice (AD model) received EA stimulation at specific acupoints. Cognitive abilities were evaluated using the Morris water maze test, while neuronal morphology and tau pathology were assessed through Nissl staining and immunofluorescence staining, respectively. Metabolic variations and BAT thermogenesis were measured using ELISA, HE staining, Western blotting, and infrared thermal imaging.ResultsCompared to SAMR1 mice, SAMP8 mice showed impaired cognitive ability, neuronal damage, disrupted thermoregulation, and metabolic disorders with low BAT activity. Both the EA and DD groups improved cognitive ability and decreased tau phosphorylation (p<0.01 or p<0.05). However, only the EA group had a significant effect on metabolic disorders and BAT thermogenesis (p<0.01 or p<0.05), while the DD group did not.ConclusionThese findings indicate that EA not only improves the cognitive ability of SAMP8 mice, but also effectively regulates peripheral and central metabolic disorders, with this effect being significantly related to the activation of BAT thermogenesis. |
| first_indexed | 2024-03-08T14:37:12Z |
| format | Article |
| id | doaj.art-5850f7dbd67c40bd8d4beafbf0c5ff65 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T14:37:12Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-5850f7dbd67c40bd8d4beafbf0c5ff652024-01-12T04:36:10ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-01-011410.3389/fendo.2023.13305651330565Electroacupuncture stimulation improves cognitive ability and regulates metabolic disorders in Alzheimer’s disease model mice: new insights from brown adipose tissue thermogenesisTing Li0Junjian Tian1Meng Wu2Yuanshuo Tian3Zhigang Li4School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaDongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaSchool of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, ChinaBackgroundMetabolic defects play a crucial role in Alzheimer’s disease (AD) development. Brown adipose tissue (BAT) has been identified as a novel potential therapeutic target for AD due to its unique role in energy metabolism. Electroacupuncture (EA) shows promise in improving cognitive ability and brain glucose metabolism in AD, but its effects on peripheral and central metabolism are unclear.MethodsIn this study, SAMP8 mice (AD model) received EA stimulation at specific acupoints. Cognitive abilities were evaluated using the Morris water maze test, while neuronal morphology and tau pathology were assessed through Nissl staining and immunofluorescence staining, respectively. Metabolic variations and BAT thermogenesis were measured using ELISA, HE staining, Western blotting, and infrared thermal imaging.ResultsCompared to SAMR1 mice, SAMP8 mice showed impaired cognitive ability, neuronal damage, disrupted thermoregulation, and metabolic disorders with low BAT activity. Both the EA and DD groups improved cognitive ability and decreased tau phosphorylation (p<0.01 or p<0.05). However, only the EA group had a significant effect on metabolic disorders and BAT thermogenesis (p<0.01 or p<0.05), while the DD group did not.ConclusionThese findings indicate that EA not only improves the cognitive ability of SAMP8 mice, but also effectively regulates peripheral and central metabolic disorders, with this effect being significantly related to the activation of BAT thermogenesis.https://www.frontiersin.org/articles/10.3389/fendo.2023.1330565/fullAlzheimer’s diseasemetabolicbrown adipose tissuethermogenesistau pathologyelectroacupuncture |
| spellingShingle | Ting Li Junjian Tian Meng Wu Yuanshuo Tian Zhigang Li Electroacupuncture stimulation improves cognitive ability and regulates metabolic disorders in Alzheimer’s disease model mice: new insights from brown adipose tissue thermogenesis Frontiers in Endocrinology Alzheimer’s disease metabolic brown adipose tissue thermogenesis tau pathology electroacupuncture |
| title | Electroacupuncture stimulation improves cognitive ability and regulates metabolic disorders in Alzheimer’s disease model mice: new insights from brown adipose tissue thermogenesis |
| title_full | Electroacupuncture stimulation improves cognitive ability and regulates metabolic disorders in Alzheimer’s disease model mice: new insights from brown adipose tissue thermogenesis |
| title_fullStr | Electroacupuncture stimulation improves cognitive ability and regulates metabolic disorders in Alzheimer’s disease model mice: new insights from brown adipose tissue thermogenesis |
| title_full_unstemmed | Electroacupuncture stimulation improves cognitive ability and regulates metabolic disorders in Alzheimer’s disease model mice: new insights from brown adipose tissue thermogenesis |
| title_short | Electroacupuncture stimulation improves cognitive ability and regulates metabolic disorders in Alzheimer’s disease model mice: new insights from brown adipose tissue thermogenesis |
| title_sort | electroacupuncture stimulation improves cognitive ability and regulates metabolic disorders in alzheimer s disease model mice new insights from brown adipose tissue thermogenesis |
| topic | Alzheimer’s disease metabolic brown adipose tissue thermogenesis tau pathology electroacupuncture |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1330565/full |
| work_keys_str_mv | AT tingli electroacupuncturestimulationimprovescognitiveabilityandregulatesmetabolicdisordersinalzheimersdiseasemodelmicenewinsightsfrombrownadiposetissuethermogenesis AT junjiantian electroacupuncturestimulationimprovescognitiveabilityandregulatesmetabolicdisordersinalzheimersdiseasemodelmicenewinsightsfrombrownadiposetissuethermogenesis AT mengwu electroacupuncturestimulationimprovescognitiveabilityandregulatesmetabolicdisordersinalzheimersdiseasemodelmicenewinsightsfrombrownadiposetissuethermogenesis AT yuanshuotian electroacupuncturestimulationimprovescognitiveabilityandregulatesmetabolicdisordersinalzheimersdiseasemodelmicenewinsightsfrombrownadiposetissuethermogenesis AT zhigangli electroacupuncturestimulationimprovescognitiveabilityandregulatesmetabolicdisordersinalzheimersdiseasemodelmicenewinsightsfrombrownadiposetissuethermogenesis |