Hsp90 the concertmaster: tuning transcription
In the last decade Hsp90 has emerged as a major regulator of cancer cell growth and proliferation. In cancer cells, it assists in giving maturation to oncogenic proteins including several kinases and transcription factors. Recent studies have shown that apart from its chaperone activity, it also imp...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2015-04-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00100/full |
| _version_ | 1818498638083522560 |
|---|---|
| author | Nidhi eKhurana Sunanda eBhattacharyya |
| author_facet | Nidhi eKhurana Sunanda eBhattacharyya |
| author_sort | Nidhi eKhurana |
| collection | DOAJ |
| description | In the last decade Hsp90 has emerged as a major regulator of cancer cell growth and proliferation. In cancer cells, it assists in giving maturation to oncogenic proteins including several kinases and transcription factors. Recent studies have shown that apart from its chaperone activity, it also imparts regulation of transcription machinery and thereby alters the cellular physiology. Hsp90 and its co-chaperones modulate transcription at-least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Secondly, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Thirdly, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. In this review, we discuss the role of Hsp90 in all the three aforementioned mechanisms of transcriptional control, taking examples from various model organisms with a special emphasis on cancer progression. |
| first_indexed | 2024-12-10T20:18:18Z |
| format | Article |
| id | doaj.art-5851cda7d4cf4995b270bc3b83a1a84f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-10T20:18:18Z |
| publishDate | 2015-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-5851cda7d4cf4995b270bc3b83a1a84f2022-12-22T01:35:07ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-04-01510.3389/fonc.2015.00100139598Hsp90 the concertmaster: tuning transcriptionNidhi eKhurana0Sunanda eBhattacharyya1University of Hyderabad, Department of Biotechnology and Bioinformatics, School of Life Sciences, IndiaUniversity of Hyderabad, Department of Biotechnology and Bioinformatics, School of Life Sciences, IndiaIn the last decade Hsp90 has emerged as a major regulator of cancer cell growth and proliferation. In cancer cells, it assists in giving maturation to oncogenic proteins including several kinases and transcription factors. Recent studies have shown that apart from its chaperone activity, it also imparts regulation of transcription machinery and thereby alters the cellular physiology. Hsp90 and its co-chaperones modulate transcription at-least at three different levels. In the first place, they alter the steady-state levels of certain transcription factors in response to various physiological cues. Secondly, they modulate the activity of certain epigenetic modifiers, such as histone deacetylases or DNA methyl transferases, and thereby respond to the change in the environment. Thirdly, they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression. In this review, we discuss the role of Hsp90 in all the three aforementioned mechanisms of transcriptional control, taking examples from various model organisms with a special emphasis on cancer progression.http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00100/fullTranscription FactorsCancertranscriptionChromatin modifiersHsp90 |
| spellingShingle | Nidhi eKhurana Sunanda eBhattacharyya Hsp90 the concertmaster: tuning transcription Frontiers in Oncology Transcription Factors Cancer transcription Chromatin modifiers Hsp90 |
| title | Hsp90 the concertmaster: tuning transcription |
| title_full | Hsp90 the concertmaster: tuning transcription |
| title_fullStr | Hsp90 the concertmaster: tuning transcription |
| title_full_unstemmed | Hsp90 the concertmaster: tuning transcription |
| title_short | Hsp90 the concertmaster: tuning transcription |
| title_sort | hsp90 the concertmaster tuning transcription |
| topic | Transcription Factors Cancer transcription Chromatin modifiers Hsp90 |
| url | http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00100/full |
| work_keys_str_mv | AT nidhiekhurana hsp90theconcertmastertuningtranscription AT sunandaebhattacharyya hsp90theconcertmastertuningtranscription |