Dll1 haploinsufficiency causes brain abnormalities with functional relevance

Dll1 haploinsufficiency causes brain abnormalities with functional relevance

IntroductionThe Notch pathway is fundamental for the generation of neurons during development. We previously reported that adult mice heterozygous for the null allele of the gene encoding the Delta-like ligand 1 for Notch (Dll1lacZ) have a reduced neuronal density in the substantia nigra pars compac...

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Bibliographic Details
Main Authors: Dulce-María Arzate, Concepción Valencia, Marco-Antonio Dimas, Edwards Antonio-Cabrera, Emilio Domínguez-Salazar, Gilda Guerrero-Flores, Mariana Gutiérrez-Mariscal, Luis Covarrubias
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Neuroscience
Subjects:
notch signaling
neuronal density
microcephaly
hydrocephalus
myelination
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.951418/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.951418/full

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