Effects of <em>Ficus pandurata</em> Hance var. <em>angustifolia</em> Cheng Flavonoids on Intestinal Barrier and Cognitive Function by Regulating Intestinal Microbiota
More and more evidence has supported the interaction between circadian rhythms and intestinal microbes, which provides new insights into how dietary nutrition can improve host health. Our research showed that <i>Ficus pandurata</i> Hance var. <i>angustifolia</i> Cheng flavono...
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| Format: | Article |
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MDPI AG
2023-04-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/12/8/1682 |
| _version_ | 1797605435148075008 |
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| author | Yuting Zhang Junjie Pan Yanan Liu Xin Zhang Kejun Cheng |
| author_facet | Yuting Zhang Junjie Pan Yanan Liu Xin Zhang Kejun Cheng |
| author_sort | Yuting Zhang |
| collection | DOAJ |
| description | More and more evidence has supported the interaction between circadian rhythms and intestinal microbes, which provides new insights into how dietary nutrition can improve host health. Our research showed that <i>Ficus pandurata</i> Hance var. <i>angustifolia</i> Cheng flavonoids (FCF) ameliorated the pathological damage of colon and abnormal intestinal microflora structure in mice with circadian clock disorder and improved their exploration and memory behaviors. Mechanism studies have shown that FCF is involved in regulating metabolic pathways and related metabolites, regulating the expression of related tight junction proteins in the colon and the levels of Aβ and inflammatory factors in the hippocampus. Further analysis found that these metabolites showed a certain correlation with intestinal flora and played a certain role in alleviating intestinal physiological damage and cognitive decline. |
| first_indexed | 2024-03-11T05:01:04Z |
| format | Article |
| id | doaj.art-58554582d203428dba01cd422b29c299 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-11T05:01:04Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-58554582d203428dba01cd422b29c2992023-11-17T19:15:11ZengMDPI AGFoods2304-81582023-04-01128168210.3390/foods12081682Effects of <em>Ficus pandurata</em> Hance var. <em>angustifolia</em> Cheng Flavonoids on Intestinal Barrier and Cognitive Function by Regulating Intestinal MicrobiotaYuting Zhang0Junjie Pan1Yanan Liu2Xin Zhang3Kejun Cheng4Department of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaChemical Biology Center, Lishui Institute of Agriculture and Forestry Sciences, Lishui 323000, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaMore and more evidence has supported the interaction between circadian rhythms and intestinal microbes, which provides new insights into how dietary nutrition can improve host health. Our research showed that <i>Ficus pandurata</i> Hance var. <i>angustifolia</i> Cheng flavonoids (FCF) ameliorated the pathological damage of colon and abnormal intestinal microflora structure in mice with circadian clock disorder and improved their exploration and memory behaviors. Mechanism studies have shown that FCF is involved in regulating metabolic pathways and related metabolites, regulating the expression of related tight junction proteins in the colon and the levels of Aβ and inflammatory factors in the hippocampus. Further analysis found that these metabolites showed a certain correlation with intestinal flora and played a certain role in alleviating intestinal physiological damage and cognitive decline.https://www.mdpi.com/2304-8158/12/8/1682<i>Ficus pandurata</i> Hance var. <i>angustifolia</i> Cheng flavonoidsintestinal barrierintestinal microbiotacognitive function |
| spellingShingle | Yuting Zhang Junjie Pan Yanan Liu Xin Zhang Kejun Cheng Effects of <em>Ficus pandurata</em> Hance var. <em>angustifolia</em> Cheng Flavonoids on Intestinal Barrier and Cognitive Function by Regulating Intestinal Microbiota Foods <i>Ficus pandurata</i> Hance var. <i>angustifolia</i> Cheng flavonoids intestinal barrier intestinal microbiota cognitive function |
| title | Effects of <em>Ficus pandurata</em> Hance var. <em>angustifolia</em> Cheng Flavonoids on Intestinal Barrier and Cognitive Function by Regulating Intestinal Microbiota |
| title_full | Effects of <em>Ficus pandurata</em> Hance var. <em>angustifolia</em> Cheng Flavonoids on Intestinal Barrier and Cognitive Function by Regulating Intestinal Microbiota |
| title_fullStr | Effects of <em>Ficus pandurata</em> Hance var. <em>angustifolia</em> Cheng Flavonoids on Intestinal Barrier and Cognitive Function by Regulating Intestinal Microbiota |
| title_full_unstemmed | Effects of <em>Ficus pandurata</em> Hance var. <em>angustifolia</em> Cheng Flavonoids on Intestinal Barrier and Cognitive Function by Regulating Intestinal Microbiota |
| title_short | Effects of <em>Ficus pandurata</em> Hance var. <em>angustifolia</em> Cheng Flavonoids on Intestinal Barrier and Cognitive Function by Regulating Intestinal Microbiota |
| title_sort | effects of em ficus pandurata em hance var em angustifolia em cheng flavonoids on intestinal barrier and cognitive function by regulating intestinal microbiota |
| topic | <i>Ficus pandurata</i> Hance var. <i>angustifolia</i> Cheng flavonoids intestinal barrier intestinal microbiota cognitive function |
| url | https://www.mdpi.com/2304-8158/12/8/1682 |
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