AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy
The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM compar...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2005-01-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/10/1/105/ |
| _version_ | 1818162074867466240 |
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| author | P. Hildgen V. Nadeau |
| author_facet | P. Hildgen V. Nadeau |
| author_sort | P. Hildgen |
| collection | DOAJ |
| description | The aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM comparative studies in tapping mode were performed; on cationic copolymer and on PLA-Schiff base copolymer, on non-oriented and oriented film and on the DNA-cationic complex. The results indicated a difference in the topology and on phase picture of AFM film with or without cationic charge. |
| first_indexed | 2024-12-11T16:27:53Z |
| format | Article |
| id | doaj.art-58556e502d8a405fa0f5092217677fad |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T16:27:53Z |
| publishDate | 2005-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-58556e502d8a405fa0f5092217677fad2022-12-22T00:58:41ZengMDPI AGMolecules1420-30492005-01-0110110511310.3390/10010105AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene TherapyP. HildgenV. NadeauThe aim of this study was to synthesize novel biodegradable charged polymers to be used in DNA complexation for genetic delivery in different diseases. A new copolymer of PLA and complexed Schiff bases was synthesized in a several steps. This copolymer will be used as a nanocarrier. Also, AFM comparative studies in tapping mode were performed; on cationic copolymer and on PLA-Schiff base copolymer, on non-oriented and oriented film and on the DNA-cationic complex. The results indicated a difference in the topology and on phase picture of AFM film with or without cationic charge.http://www.mdpi.com/1420-3049/10/1/105/AFMPLAGenetic TherapyVectorSalenSchiff base. |
| spellingShingle | P. Hildgen V. Nadeau AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy Molecules AFM PLA Genetic Therapy Vector Salen Schiff base. |
| title | AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy |
| title_full | AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy |
| title_fullStr | AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy |
| title_full_unstemmed | AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy |
| title_short | AFM study of a New Carrier Based on PLA and Salen Copolymers for Gene Therapy |
| title_sort | afm study of a new carrier based on pla and salen copolymers for gene therapy |
| topic | AFM PLA Genetic Therapy Vector Salen Schiff base. |
| url | http://www.mdpi.com/1420-3049/10/1/105/ |
| work_keys_str_mv | AT phildgen afmstudyofanewcarrierbasedonplaandsalencopolymersforgenetherapy AT vnadeau afmstudyofanewcarrierbasedonplaandsalencopolymersforgenetherapy |