Role of Increased Lipoprotein (a) in Retinal Vein Occlusion: A Systematic Review and Meta-analysis
Background Increased lipoprotein (a) [Lp(a)] has been associated with enhanced risk of cardiovascular events and more recently with venous thromboembolism. However, there is inconclusive data on the association between enhanced Lp(a) and retinal vein occlusion (RVO). We aimed to assess the role of L...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Georg Thieme Verlag KG
2021-07-01
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| Series: | TH Open |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1732803 |
| _version_ | 1818621486975418368 |
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| author | Francesco Paciullo David Giannandrea Gianni Virgili Carlo Cagini Paolo Gresele |
| author_facet | Francesco Paciullo David Giannandrea Gianni Virgili Carlo Cagini Paolo Gresele |
| author_sort | Francesco Paciullo |
| collection | DOAJ |
| description | Background Increased lipoprotein (a) [Lp(a)] has been associated with enhanced risk of cardiovascular events and more recently with venous thromboembolism. However, there is inconclusive data on the association between enhanced Lp(a) and retinal vein occlusion (RVO). We aimed to assess the role of Lp(a) in RVO.
Methods We performed a systematic review and meta-analysis of the studies addressing the role of Lp(a) in RVO. A systematic literature search was performed to identify all published papers reporting Lp(a) levels. Main outcome measures consisted of Lp(a) levels in patients with (cases) or without (controls) RVO.
Results We included 13 studies for a total of 1,040 cases and 16,648 controls. Lp(a) levels above normal limits were associated with RVO (OR 2.38, 95% CI 1.7–3.34) and patients with RVO had higher Lp(a) levels than controls (weighted mean difference: 13.4 mg/dL, 95% CI 8.2–18.6).
Conclusion Increased Lp(a) levels associate with RVO and should be included among diagnostic and prognostic indexes for this unusual-site vein thrombosis. Therapeutic interventions aimed to lower Lp(a) should be tested in RVO patients. |
| first_indexed | 2024-12-16T18:10:03Z |
| format | Article |
| id | doaj.art-58563da6ad1749738c919588160bd4fb |
| institution | Directory Open Access Journal |
| issn | 2512-9465 |
| language | English |
| last_indexed | 2024-12-16T18:10:03Z |
| publishDate | 2021-07-01 |
| publisher | Georg Thieme Verlag KG |
| record_format | Article |
| series | TH Open |
| spelling | doaj.art-58563da6ad1749738c919588160bd4fb2022-12-21T22:21:48ZengGeorg Thieme Verlag KGTH Open2512-94652021-07-010503e295e30210.1055/s-0041-1732803Role of Increased Lipoprotein (a) in Retinal Vein Occlusion: A Systematic Review and Meta-analysisFrancesco Paciullo0David Giannandrea1Gianni Virgili2Carlo Cagini3Paolo Gresele4Division of Internal and Cardiovascular Medicine, Department of Medicine and Surgery, University of Perugia, Perugia, ItalyDivision of Neurology and Stroke Unit, Department of Neurology, Gubbio and Città di Castello Hospital, Perugia, ItalyDepartment of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), Ophthalmology Clinic, University of Firenze and AOU Careggi, Florence, ItalySection of Ophthalmology, Department of Medicine and Surgery, University of Perugia, Perugia, ItalyDivision of Internal and Cardiovascular Medicine, Department of Medicine and Surgery, University of Perugia, Perugia, ItalyBackground Increased lipoprotein (a) [Lp(a)] has been associated with enhanced risk of cardiovascular events and more recently with venous thromboembolism. However, there is inconclusive data on the association between enhanced Lp(a) and retinal vein occlusion (RVO). We aimed to assess the role of Lp(a) in RVO. Methods We performed a systematic review and meta-analysis of the studies addressing the role of Lp(a) in RVO. A systematic literature search was performed to identify all published papers reporting Lp(a) levels. Main outcome measures consisted of Lp(a) levels in patients with (cases) or without (controls) RVO. Results We included 13 studies for a total of 1,040 cases and 16,648 controls. Lp(a) levels above normal limits were associated with RVO (OR 2.38, 95% CI 1.7–3.34) and patients with RVO had higher Lp(a) levels than controls (weighted mean difference: 13.4 mg/dL, 95% CI 8.2–18.6). Conclusion Increased Lp(a) levels associate with RVO and should be included among diagnostic and prognostic indexes for this unusual-site vein thrombosis. Therapeutic interventions aimed to lower Lp(a) should be tested in RVO patients.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1732803cardiovascular riskretinal vein occlusionunusual site vein thrombosis |
| spellingShingle | Francesco Paciullo David Giannandrea Gianni Virgili Carlo Cagini Paolo Gresele Role of Increased Lipoprotein (a) in Retinal Vein Occlusion: A Systematic Review and Meta-analysis TH Open cardiovascular risk retinal vein occlusion unusual site vein thrombosis |
| title | Role of Increased Lipoprotein (a) in Retinal Vein Occlusion: A Systematic Review and Meta-analysis |
| title_full | Role of Increased Lipoprotein (a) in Retinal Vein Occlusion: A Systematic Review and Meta-analysis |
| title_fullStr | Role of Increased Lipoprotein (a) in Retinal Vein Occlusion: A Systematic Review and Meta-analysis |
| title_full_unstemmed | Role of Increased Lipoprotein (a) in Retinal Vein Occlusion: A Systematic Review and Meta-analysis |
| title_short | Role of Increased Lipoprotein (a) in Retinal Vein Occlusion: A Systematic Review and Meta-analysis |
| title_sort | role of increased lipoprotein a in retinal vein occlusion a systematic review and meta analysis |
| topic | cardiovascular risk retinal vein occlusion unusual site vein thrombosis |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1732803 |
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