PRODUCTS OF METABOLISM OF THE INTESTINAL MICROFLORA: CAN WE USE THE SELECTIVE CORRECTION?
Disturbed quantitative and qualitative characteristics of the intestinal microbiota are one of the reasons for the development of a wide range of pathological conditions in any age group. To correct these disorders, probiotics (active microflora drugs) and prebiotics (oligosaccharides that promote t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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"Paediatrician" Publishers LLC
2015-04-01
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| Series: | Вопросы современной педиатрии |
| Subjects: | |
| Online Access: | https://vsp.spr-journal.ru/jour/article/view/61 |
| Summary: | Disturbed quantitative and qualitative characteristics of the intestinal microbiota are one of the reasons for the development of a wide range of pathological conditions in any age group. To correct these disorders, probiotics (active microflora drugs) and prebiotics (oligosaccharides that promote the growth of positive flora) are used. The use of metabolic prebiotics is also promising. Metabolic prebiotics are extracts of metabolic products of positive flora that, like the oligosaccharide prebiotics, stimulate the growth of the microbiota. Comparative analysis of the metabolome of some representatives of the intestinal microflora and preparations containing metabolic products of bacteria explains the mechanisms of their therapeutic effects and opens up prospects for the development of integrated treatment with the use of vitamins B6, B2, carotenoids, selenium, and glutathione. The results of the metabolome analysis suggest that the metabolites of the microflora representatives such as Escherichia coli, Streptococcus faecalis, Lactobacillus acidophilus, and Lactobacillus helveticus promote the survival of positive flora and at the same time can inhibit the growth of pathogenic microflora. |
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| ISSN: | 1682-5527 1682-5535 |