Efficient multitool/multiplex gene engineering with TALE-BE

Efficient multitool/multiplex gene engineering with TALE-BE

TALE base editors are a recent addition to the genome editing toolbox. These molecular tools are fusions of a transcription activator-like effector domain (TALE), split-DddA deaminase halves, and an uracil glycosylase inhibitor (UGI) that have the distinct ability to directly edit double strand DNA,...

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Bibliographic Details
Main Authors: Alex Boyne, Ming Yang, Sylvain Pulicani, Maria Feola, Diane Tkach, Robert Hong, Aymeric Duclert, Philippe Duchateau, Alexandre Juillerat
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
gene editing
base editors
TALE
t-cells
cell engineering
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.1033669/full

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