Role of the PD-1/PD-L1 Pathway in Experimental Trypanosoma cruzi Infection and Potential Therapeutic Options

Role of the PD-1/PD-L1 Pathway in Experimental Trypanosoma cruzi Infection and Potential Therapeutic Options

Chagas disease (CD) is a neglected chronic infection caused by the protozoan parasite Trypanosoma cruzi (T. cruzi). A significant portion of infected people develops cardiac or digestive alterations over a lifetime. Since several chronic infections associated with antigen persistence and inflammatio...

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Bibliographic Details
Main Authors: Yanina Arana, Rosa Isela Gálvez, Thomas Jacobs
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
Trypanosoma cruzi
co-inhibitory receptors
Chagas Disease
PD-L1
PD-1
Tim-3.
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.866120/full

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