The Anti-Coronavirus Therapies (ACT) Trials: Design, Baseline Characteristics, and Challenges

The Anti-Coronavirus Therapies (ACT) Trials: Design, Baseline Characteristics, and Challenges

Background: Effective treatments for COVID-19 are urgently needed, but conducting randomized trials during the pandemic has been challenging. Methods: The Anti-Coronavirus Therapy (ACT) trials are parallel factorial international trials that aimed to enroll 3500 outpatients and 2500 inpatients with...

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Main Authors: John Eikelboom, MBBS, MSc, Sumathy Rangarajan, MSc, Sanjit S. Jolly, MD, Emilie P. Belley-Cote, MD, PhD, Richard Whitlock, MD, PhD, Heather Beresh, MSc, Gayle Lewis, Lizhen Xu, PhD, Noel Chan, MD, Shrikant Bangdiwala, PhD, Rafael Diaz, MD, Andres Orlandini, MD, Mohamed Hassany, MD, Wadea M. Tarhuni, MD, A.M. Yusufali, MD, Sanjib Kumar Sharma, MD, Anna Kontsevaya, PhD, Patricio Lopez-Jaramillo, MD, Alvaro Avezum, MD, Antonio L. Dans, MD, Sean Wasserman, MBChB, Camilo Felix, MD, Khawar Kazmi, MD, Prem Pais, MD, Denis Xavier, MD, Renato D. Lopes, MD, PhD, Otavio Berwanger, MD, Menelas Nkeshimana, MMed, William Harper, MD, Mark Loeb, MD, Shurjeel Choudhri, MD, Michael E. Farkouh, MD, Jackie Bosch, PhD, Sonia S. Anand, PhD, Salim Yusuf, DPhil
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:CJC Open
Online Access:http://www.sciencedirect.com/science/article/pii/S2589790X22000488

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