Dietary restriction with and without caloric restriction for healthy aging [version 1; referees: 3 approved]
Caloric restriction is the most effective and reproducible dietary intervention known to regulate aging and increase the healthy lifespan in various model organisms, ranging from the unicellular yeast to worms, flies, rodents, and primates. However, caloric restriction, which in most cases entails a...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2016-01-01
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| Series: | F1000Research |
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| Online Access: | http://f1000research.com/articles/5-117/v1 |
| _version_ | 1818335464606662656 |
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| author | Changhan Lee Valter Longo |
| author_facet | Changhan Lee Valter Longo |
| author_sort | Changhan Lee |
| collection | DOAJ |
| description | Caloric restriction is the most effective and reproducible dietary intervention known to regulate aging and increase the healthy lifespan in various model organisms, ranging from the unicellular yeast to worms, flies, rodents, and primates. However, caloric restriction, which in most cases entails a 20–40% reduction of food consumption relative to normal intake, is a severe intervention that results in both beneficial and detrimental effects. Specific types of chronic, intermittent, or periodic dietary restrictions without chronic caloric restriction have instead the potential to provide a significant healthspan increase while minimizing adverse effects. Improved periodic or targeted dietary restriction regimens that uncouple the challenge of food deprivation from the beneficial effects will allow a safe intervention feasible for a major portion of the population. Here we focus on healthspan interventions that are not chronic or do not require calorie restriction. |
| first_indexed | 2024-12-13T14:23:51Z |
| format | Article |
| id | doaj.art-585c1c2efba64ef6b5f14103b45af045 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-12-13T14:23:51Z |
| publishDate | 2016-01-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-585c1c2efba64ef6b5f14103b45af0452022-12-21T23:41:59ZengF1000 Research LtdF1000Research2046-14022016-01-01510.12688/f1000research.7136.17686Dietary restriction with and without caloric restriction for healthy aging [version 1; referees: 3 approved]Changhan Lee0Valter Longo1Davis School of Gerontology, University of Southern California, Los Angeles, CA, USAIFOM - FIRC Institute of Molecular Oncology Foundation, Milan, ItalyCaloric restriction is the most effective and reproducible dietary intervention known to regulate aging and increase the healthy lifespan in various model organisms, ranging from the unicellular yeast to worms, flies, rodents, and primates. However, caloric restriction, which in most cases entails a 20–40% reduction of food consumption relative to normal intake, is a severe intervention that results in both beneficial and detrimental effects. Specific types of chronic, intermittent, or periodic dietary restrictions without chronic caloric restriction have instead the potential to provide a significant healthspan increase while minimizing adverse effects. Improved periodic or targeted dietary restriction regimens that uncouple the challenge of food deprivation from the beneficial effects will allow a safe intervention feasible for a major portion of the population. Here we focus on healthspan interventions that are not chronic or do not require calorie restriction.http://f1000research.com/articles/5-117/v1AgingAnimal GeneticsControl of Gene ExpressionDevelopmental Molecular MechanismsEndocrinologyIntegrative PhysiologyMedical GeneticsNeurobiology of Disease & Regeneration |
| spellingShingle | Changhan Lee Valter Longo Dietary restriction with and without caloric restriction for healthy aging [version 1; referees: 3 approved] F1000Research Aging Animal Genetics Control of Gene Expression Developmental Molecular Mechanisms Endocrinology Integrative Physiology Medical Genetics Neurobiology of Disease & Regeneration |
| title | Dietary restriction with and without caloric restriction for healthy aging [version 1; referees: 3 approved] |
| title_full | Dietary restriction with and without caloric restriction for healthy aging [version 1; referees: 3 approved] |
| title_fullStr | Dietary restriction with and without caloric restriction for healthy aging [version 1; referees: 3 approved] |
| title_full_unstemmed | Dietary restriction with and without caloric restriction for healthy aging [version 1; referees: 3 approved] |
| title_short | Dietary restriction with and without caloric restriction for healthy aging [version 1; referees: 3 approved] |
| title_sort | dietary restriction with and without caloric restriction for healthy aging version 1 referees 3 approved |
| topic | Aging Animal Genetics Control of Gene Expression Developmental Molecular Mechanisms Endocrinology Integrative Physiology Medical Genetics Neurobiology of Disease & Regeneration |
| url | http://f1000research.com/articles/5-117/v1 |
| work_keys_str_mv | AT changhanlee dietaryrestrictionwithandwithoutcaloricrestrictionforhealthyagingversion1referees3approved AT valterlongo dietaryrestrictionwithandwithoutcaloricrestrictionforhealthyagingversion1referees3approved |