Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway

Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK/SIRT1 signaling pathway

Non-alcoholic fatty liver disease (NAFLD) has become one of the main chronic liver diseases worldwide. Protopanaxadiol (PPD), an active compound derived from Gynostemma pentaphyllum, has been found able to improve free fatty acid-induced lipid accumulation in hepatocytes. However, the efficacy of PP...

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Bibliographic Details
Main Authors: Yiping Li, Yang Liu, Zhiwei Chen, Kaiyue Tang, Lili Yang, Yuwei Jiang, Jue Wang, Ping Huang, Jianyi Wang, Peiyong Zheng, Haiyan Song
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Non-alcoholic fatty liver disease
Protopanaxadiol
Lipid metabolism
AMPK
SIRT1
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223001075

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