Mu-opioid receptor and receptor tyrosine kinase crosstalk: Implications in mechanisms of opioid tolerance, reduced analgesia to neuropathic pain, dependence, and reward

Mu-opioid receptor and receptor tyrosine kinase crosstalk: Implications in mechanisms of opioid tolerance, reduced analgesia to neuropathic pain, dependence, and reward

Despite the prevalence of opioid misuse, opioids remain the frontline treatment regimen for severe pain. However, opioid safety is hampered by side-effects such as analgesic tolerance, reduced analgesia to neuropathic pain, physical dependence, or reward. These side effects promote development of op...

Full description

Bibliographic Details
Main Authors: Mackenzie C. Gamble, Benjamin R. Williams, Navsharan Singh, Luca Posa, Zachary Freyberg, Ryan W. Logan, Stephanie Puig
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Systems Neuroscience
Subjects:
mu-opioid receptor
opioid signaling
pain
tolerance
neuropathic pain
physical dependence
Online Access:https://www.frontiersin.org/articles/10.3389/fnsys.2022.1059089/full

Similar Items

Similar Items